Introduction: Novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds

Publication type:
Journal article
Metadata:
Autoren
  • Hildebert Wagner
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000417365100001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2017.10.020
Externe Identifier
  • Clarivate Analytics Document Solution ID: FP1IK
  • PubMed Identifier: 29174652
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Antibiotics
  • Natural products
  • Network pharmacology
  • Phytochemicals
  • Synergism
Paginierung
1 - 3
Datum der Veröffentlichung
2017
Status
Published
Titel
Introduction: Novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds
Sub types
  • Editorial Material
Ausgabe der Zeitschrift
37

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Hildebert Wagner
  • Thomas Efferth
DOI
10.1016/j.phymed.2017.10.020
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Paginierung
1 - 3
Datum der Veröffentlichung
2017
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2017.10.020
Datum der Datenerfassung
2018
Titel
Introduction: Novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds
Ausgabe der Zeitschrift
37

Data source: Crossref

Abstract
<h4>Background</h4>There is a paradigm shift in chemotherapy from mono-drug therapy towards multidrug combination regimens. Natural products from medicinal plants may play an important role for the design of novel combination therapy protocols.<h4>Hypothesis</h4>We introduce the novel term "hybrid combination" for the therapeutic combination of chemically defined plant-derived constituents (e.g. phenolic or terpenoid compounds with synthetic or antibiotic drugs to increase pharmacological activity and simultaneously toxic side effects.<h4>Study design</h4>Several literature databases were screened on the combination of phenolic/terpenoid compounds with synthetic/antibiotic drugs.<h4>Results</h4>Phenolic compounds are water soluble and interact with target proteins due to their OH-groups. They reveal antioxident, antiinflammatory and sometimes apoptotic activities whereas the terpenoids possess due to their lipophilic nature together with the phenolics amphiphilic properties and thereby good cell-penetrating features<sub>.</sub> They reveal antioxidant properties, anti-inflammatory and sometimes apoptotic activities as well as cell-penetrating features due to their amphiphilicity. Synergistic or antagonistic interactions with synthetic or antibiotic drugs have to be demonstrated by using suitable methods (e.g. isobologram analysis). The molecular modes of action may be elucidated by approaches of network pharmacology (e.g. protein-protein interaction networks).<h4>Conclusion</h4>There is convincing evidence for the improvement of pharmacological activity at reduced side effects by hybrid combinations. Future efforts should focus on clinical trials with hybrid combinations to treat a broad range of diverse diseases such as cardiometabolic and neurotropic syndromes, drug resistance phenotypes, and so-called neglected infectious diseases.
Addresses
  • Department Pharmacy, Center for Pharma Research, Butenandtstr. 5, House B, 81377 Munich, Germany. Electronic address: Wagner.Breitbrunn@t-online.de.
Autoren
DOI
10.1016/j.phymed.2017.10.020
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 29174652
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Plants, Medicinal
  • Terpenes
  • Phenols
  • Plant Extracts
  • Biological Products
  • Antioxidants
  • Anti-Bacterial Agents
  • Drug Therapy, Combination
  • Herb-Drug Interactions
Sprache
eng
Medium
Print-Electronic
Online publication date
2017
Paginierung
1 - 3
Datum der Veröffentlichung
2017
Status
Published
Datum der Datenerfassung
2017
Titel
Introduction: Novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
37

Data source: Europe PubMed Central

Abstract
BACKGROUND: There is a paradigm shift in chemotherapy from mono-drug therapy towards multidrug combination regimens. Natural products from medicinal plants may play an important role for the design of novel combination therapy protocols. HYPOTHESIS: We introduce the novel term "hybrid combination" for the therapeutic combination of chemically defined plant-derived constituents (e.g. phenolic or terpenoid compounds with synthetic or antibiotic drugs to increase pharmacological activity and simultaneously toxic side effects. STUDY DESIGN: Several literature databases were screened on the combination of phenolic/terpenoid compounds with synthetic/antibiotic drugs. RESULTS: Phenolic compounds are water soluble and interact with target proteins due to their OH-groups. They reveal antioxident, antiinflammatory and sometimes apoptotic activities whereas the terpenoids possess due to their lipophilic nature together with the phenolics amphiphilic properties and thereby good cell-penetrating features. They reveal antioxidant properties, anti-inflammatory and sometimes apoptotic activities as well as cell-penetrating features due to their amphiphilicity. Synergistic or antagonistic interactions with synthetic or antibiotic drugs have to be demonstrated by using suitable methods (e.g. isobologram analysis). The molecular modes of action may be elucidated by approaches of network pharmacology (e.g. protein-protein interaction networks). CONCLUSION: There is convincing evidence for the improvement of pharmacological activity at reduced side effects by hybrid combinations. Future efforts should focus on clinical trials with hybrid combinations to treat a broad range of diverse diseases such as cardiometabolic and neurotropic syndromes, drug resistance phenotypes, and so-called neglected infectious diseases.
Date of acceptance
2017
Autoren
  • Hildebert Wagner
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29174652
DOI
10.1016/j.phymed.2017.10.020
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Antibiotics
  • Natural products
  • Network pharmacology
  • Phytochemicals
  • Synergism
  • Anti-Bacterial Agents
  • Antioxidants
  • Biological Products
  • Drug Therapy, Combination
  • Herb-Drug Interactions
  • Humans
  • Phenols
  • Plant Extracts
  • Plants, Medicinal
  • Terpenes
Sprache
eng
Country
Germany
Paginierung
1 - 3
PII
S0944-7113(17)30161-7
Datum der Veröffentlichung
2017
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Introduction: Novel hybrid combinations containing synthetic or antibiotic drugs with plant-derived phenolic or terpenoid compounds.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
37

Data source: PubMed

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