Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease

Autoren

Ean-Jeong Seo
Nicolas Fischer
Thomas Efferth

DOI

10.1016/j.phrs.2017.11.030

ISSN

1043-6618

Zeitschrift

Pharmacological Research

Sprache

en

Paginierung

262 - 273

Datum der Veröffentlichung

2018

Status

Published

Herausgeber

Elsevier BV

Herausgeber URL

http://dx.doi.org/10.1016/j.phrs.2017.11.030

Datum der Datenerfassung

2023

Titel

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

Ausgabe der Zeitschrift

129

Data source: Crossref

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway. They inhibit the phosphorylation or the ubiquitination of signaling molecules, and thus, inhibit the degradation of IκB. The translocation of NF-κB to the nucleus and subsequent transcription of pro-inflammatory cytokines are inhibited by the actions of phytochemicals. Additionally, natural compounds preventing the interaction of NF-κB can block NF-κB's transcriptional activity by inhibiting its binding to target DNA. Many polyphenols including curcumin, resveratrol, pterostilbene, punicalagin, macranthoin G, salidroside, 4-O-methylhonokiol, lycopene, genistein, obovatol and gallic acid were reported as potent NF-κB inhibitors for AD treatment. Several alkaloids such as galantamine, glaucocalyxin B, tetrandrine, berberine, oridonin, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in vivo. Besides, vitamins, tanshinone IIA, artemisinin, dihydroasparagusic acid, geniposide, xanthoceraside, l-theranine, 1,8-cineole and paeoniflorin were described as promising NF-κB inhibitors. In conclusion, natural products from plants represent interesting candidates for AD treatment. They may qualify as promising compounds for the development of derivatives providing enhanced pharmacological features.

Addresses

Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.

Autoren

Ean-Jeong Seo
Nicolas Fischer
Thomas Efferth
Thomas Efferth

DOI

10.1016/j.phrs.2017.11.030

eISSN

1096-1186

Externe Identifier

PubMed Identifier: 29179999

Open access

false

ISSN

1043-6618

Zeitschrift

Pharmacological research

Schlüsselwörter

Animals
Humans
Alzheimer Disease
Alkaloids
Vitamins
NF-kappa B
Polyphenols
Phytochemicals

Sprache

eng

Medium

Print-Electronic

Online publication date

2017

Paginierung

262 - 273

Datum der Veröffentlichung

2018

Status

Published

Datum der Datenerfassung

2017

Titel

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease.

Sub types

Review
Journal Article

Ausgabe der Zeitschrift

129

Data source: Europe PubMed Central

Abstract

Alzheimer's disease (AD) is the most prevalent form of dementia. The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. AD is highly correlated with neuroinflammation and oxidative stress in brain causing neuronal loss. Nuclear factor of activated B-cells (NF-κB) is involved in physiological inflammatory processes and thus representing a promising target for inflammation-based AD therapy. Phytochemicals are able to interfere with the NF-κB pathway. They inhibit the phosphorylation or the ubiquitination of signaling molecules, and thus, inhibit the degradation of IκB. The translocation of NF-κB to the nucleus and subsequent transcription of pro-inflammatory cytokines are inhibited by the actions of phytochemicals. Additionally, natural compounds preventing the interaction of NF-κB can block NF-κB's transcriptional activity by inhibiting its binding to target DNA. Many polyphenols including curcumin, resveratrol, pterostilbene, punicalagin, macranthoin G, salidroside, 4-O-methylhonokiol, lycopene, genistein, obovatol and gallic acid were reported as potent NF-κB inhibitors for AD treatment. Several alkaloids such as galantamine, glaucocalyxin B, tetrandrine, berberine, oridonin, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in vivo. Besides, vitamins, tanshinone IIA, artemisinin, dihydroasparagusic acid, geniposide, xanthoceraside, l-theranine, 1,8-cineole and paeoniflorin were described as promising NF-κB inhibitors. In conclusion, natural products from plants represent interesting candidates for AD treatment. They may qualify as promising compounds for the development of derivatives providing enhanced pharmacological features.

Date of acceptance

2017

Autoren

Ean-Jeong Seo
Nicolas Fischer
Thomas Efferth

Autoren-URL

https://www.ncbi.nlm.nih.gov/pubmed/29179999

DOI

10.1016/j.phrs.2017.11.030

eISSN

1096-1186

Zeitschrift

Pharmacol Res

Schlüsselwörter

Botanicals
Cognitive impairment
Medicinal plants
Natural products
Neurodegenerative diseases
Small molecule inhibitor
Alkaloids
Alzheimer Disease
Animals
Humans
NF-kappa B
Phytochemicals
Polyphenols
Vitamins

Sprache

eng

Country

Netherlands

Paginierung

262 - 273

PII

S1043-6618(17)31134-9

Datum der Veröffentlichung

2018

Status

Published

Datum, an dem der Datensatz öffentlich gemacht wurde

2019

Titel

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease.

Sub types

Journal Article
Review

Ausgabe der Zeitschrift

129

Data source: PubMed

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease

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