Medicinal Plants from Near East for Cancer Therapy

Publication type:
Journal article
Metadata:
Autoren
  • Mohammad S Abu-Darwish
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000423689200001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3389/fphar.2018.00056
eISSN
1663-9812
Externe Identifier
  • Clarivate Analytics Document Solution ID: FU2OI
  • PubMed Identifier: 29445343
Zeitschrift
FRONTIERS IN PHARMACOLOGY
Schlüsselwörter
  • complementary and alternative medicine
  • pharmacognosy
  • phytochemistry
  • traditional medicine
  • Near East
  • cancer
Artikelnummer
ARTN 56
Datum der Veröffentlichung
2018
Status
Published
Titel
Medicinal Plants from Near East for Cancer Therapy
Sub types
  • Review
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Mohammad S Abu-Darwish
  • Thomas Efferth
DOI
10.3389/fphar.2018.00056
eISSN
1663-9812
Zeitschrift
Frontiers in Pharmacology
Online publication date
2018
Status
Published online
Herausgeber
Frontiers Media SA
Herausgeber URL
http://dx.doi.org/10.3389/fphar.2018.00056
Datum der Datenerfassung
2022
Titel
Medicinal Plants from Near East for Cancer Therapy
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
<b>Background:</b> Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. <b>Methods:</b> We compiled data derived from historical ethnopharmacological information as well as <i>in vitro</i> and <i>in vivo</i> results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. <b>Results:</b> In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East. Medicinal herbs are the most dominant ethnopharmacological formula used among cancer's patients in the Near East. The data obtained highlight for the first time the most commonly used medicinal plants in the Near East area for cancer treatment illustrating their importance as natural anticancer agents. The literature survey reveals that various <i>Arum</i> species, various <i>Artemisia</i> species, <i>Calotropis procera</i>, <i>Citrullus colocynthis</i>, <i>Nigella sativa</i>, <i>Pulicaria crispa</i>, various <i>Urtica</i> species, <i>Withania somnifera</i>, and others belong to the most frequently used plants among cancer patients in the Near East countries. Molecular modes of action that have been investigated for plant extracts and isolated compounds from Near East include cell cycle arrest and apoptosis induction with participation of major player in these processes such as p53 and p21, Bcl-2, Bax, cytochrome <i>c</i> release, poly (ADP-ribose) polymerase cleavage, activation of caspases, etc. <b>Conclusion:</b> The ethnopharmacology of the Near East was influenced by Arabic and Islamic medicine and might be promising for developing new natural and safe anticancer agents. Further research is required to elucidate their cellular and molecular mechanisms and to estimate their clinical activity.
Addresses
  • Department of Basic and Applied Sciences, Shoubak University College, Al-Balqa' Applied University, Al-Salt, Jordan.
Autoren
DOI
10.3389/fphar.2018.00056
eISSN
1663-9812
Externe Identifier
  • PubMed Identifier: 29445343
  • PubMed Central ID: PMC5797783
Funding acknowledgements
  • Arab Fund for Economic and Social Development: 2016-02-02468
Open access
true
ISSN
1663-9812
Zeitschrift
Frontiers in pharmacology
Sprache
eng
Medium
Electronic-eCollection
Online publication date
2018
Open access status
Open Access
Paginierung
56
Datum der Veröffentlichung
2018
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2018
Titel
Medicinal Plants from Near East for Cancer Therapy.
Sub types
  • review-article
  • Review
  • Journal Article
Ausgabe der Zeitschrift
9

Files

https://www.frontiersin.org/articles/10.3389/fphar.2018.00056/pdf https://europepmc.org/articles/PMC5797783?pdf=render

Data source: Europe PubMed Central

Abstract
Background: Cancer is one of the major problems affecting public health worldwide. As other cultures, the populations of the Near East rely on medicinal herbs and their preparations to fight cancer. Methods: We compiled data derived from historical ethnopharmacological information as well as in vitro and in vivo results and clinical findings extracted from different literature databases including (PubMed, Scopus, Web of Science, and Google Scholar) during the past two decades. Results: In this survey, we analyzed the huge amount of data available on anticancer ethnopharmacological sources used in the Near East. Medicinal herbs are the most dominant ethnopharmacological formula used among cancer's patients in the Near East. The data obtained highlight for the first time the most commonly used medicinal plants in the Near East area for cancer treatment illustrating their importance as natural anticancer agents. The literature survey reveals that various Arum species, various Artemisia species, Calotropis procera, Citrullus colocynthis, Nigella sativa, Pulicaria crispa, various Urtica species, Withania somnifera, and others belong to the most frequently used plants among cancer patients in the Near East countries. Molecular modes of action that have been investigated for plant extracts and isolated compounds from Near East include cell cycle arrest and apoptosis induction with participation of major player in these processes such as p53 and p21, Bcl-2, Bax, cytochrome c release, poly (ADP-ribose) polymerase cleavage, activation of caspases, etc. Conclusion: The ethnopharmacology of the Near East was influenced by Arabic and Islamic medicine and might be promising for developing new natural and safe anticancer agents. Further research is required to elucidate their cellular and molecular mechanisms and to estimate their clinical activity.
Date of acceptance
2018
Autoren
  • Mohammad S Abu-Darwish
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29445343
DOI
10.3389/fphar.2018.00056
Externe Identifier
  • PubMed Central ID: PMC5797783
ISSN
1663-9812
Zeitschrift
Front Pharmacol
Schlüsselwörter
  • Near East
  • cancer
  • complementary and alternative medicine
  • pharmacognosy
  • phytochemistry
  • traditional medicine
Sprache
eng
Country
Switzerland
Paginierung
56
Datum der Veröffentlichung
2018
Status
Published online
Titel
Medicinal Plants from Near East for Cancer Therapy.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
9

Data source: PubMed

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