Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Rosa Tundis
- Monica R Loizzo
- Marco Bonesi
- Lorenzo Peruzzi
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000469988800023&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/14786419.2018.1437432
- eISSN
- 1478-6427
- Externe Identifier
- Clarivate Analytics Document Solution ID: IB0YO
- PubMed Identifier: 29431466
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- NATURAL PRODUCT RESEARCH
- Schlüsselwörter
- Daphne mezereum
- D. striata
- Thymelaeaceae
- anti-proliferative activity
- human tumour cells
- antioxidant activity
- Paginierung
- 1809 - 1812
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- <i>Daphne striata</i> Tratt. and <i>D. mezereum</i> L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties
- Sub types
- Article
- Ausgabe der Zeitschrift
- 33
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Rosa Tundis
- Monica R Loizzo
- Marco Bonesi
- Lorenzo Peruzzi
- Thomas Efferth
- DOI
- 10.1080/14786419.2018.1437432
- eISSN
- 1478-6427
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Natural Product Research
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 1809 - 1812
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/14786419.2018.1437432
- Datum der Datenerfassung
- 2020
- Titel
- <i>Daphne striata</i> Tratt. and <i>D. mezereum</i> L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties
- Ausgabe der Zeitschrift
- 33
Data source: Crossref
- Abstract
- In this study, we investigated for the first time the anti-proliferative and antioxidant properties of <i>D. mezereum</i> and <i>D. striata</i>. The aerial parts were extracted by maceration with <i>n</i>-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. <i>D. mezereum</i> dichloromethane extract showed a remarkable anti-proliferative with an IC<sub>50</sub> of 6.08 μg/mL against LNCaP cells. Experimental data indicate that <i>Daphne</i> species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.
- Addresses
- a Department of Pharmacy, Health and Nutritional Sciences , University of Calabria , Cosenza , Italy.
- Autoren
- Rosa Tundis
- Monica R Loizzo
- Marco Bonesi
- Lorenzo Peruzzi
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1080/14786419.2018.1437432
- eISSN
- 1478-6427
- Externe Identifier
- PubMed Identifier: 29431466
- Open access
- false
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Natural product research
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Daphne
- Plant Components, Aerial
- Plant Extracts
- Antineoplastic Agents, Phytogenic
- Antioxidants
- Drug Screening Assays, Antitumor
- Drug Evaluation, Preclinical
- Gas Chromatography-Mass Spectrometry
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 1809 - 1812
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- <i>Daphne striata</i> Tratt. and <i>D. mezereum</i> L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.
- Sub types
- Video-Audio Media
- Journal Article
- Ausgabe der Zeitschrift
- 33
Data source: Europe PubMed Central
- Abstract
- In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. D. mezereum dichloromethane extract showed a remarkable anti-proliferative with an IC50 of 6.08 μg/mL against LNCaP cells. Experimental data indicate that Daphne species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.
- Autoren
- Rosa Tundis
- Monica R Loizzo
- Marco Bonesi
- Lorenzo Peruzzi
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29431466
- DOI
- 10.1080/14786419.2018.1437432
- eISSN
- 1478-6427
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Nat Prod Res
- Schlüsselwörter
- Thymelaeaceae
- anti-proliferative activity
- antioxidant activity
- human tumour cells
- Antineoplastic Agents, Phytogenic
- Antioxidants
- Cell Line, Tumor
- Daphne
- Drug Evaluation, Preclinical
- Drug Screening Assays, Antitumor
- Gas Chromatography-Mass Spectrometry
- Humans
- Plant Components, Aerial
- Plant Extracts
- Sprache
- eng
- Country
- England
- Paginierung
- 1809 - 1812
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.
- Sub types
- Journal Article
- Video-Audio Media
- Ausgabe der Zeitschrift
- 33
Data source: PubMed
- Beziehungen:
- Property of