In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Manar Adam
- Gihan OM Elhassan
- Sakina Yagi
- Fatma Sezer Senol
- Ilkay Erdogan Orhan
- Abdel Azim Ahmed
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000438112600004&DestLinkType=FullRecord&DestApp=WOS
- DOI
- 10.1007/s13659-018-0155-0
- eISSN
- 2192-2209
- Externe Identifier
- Clarivate Analytics Document Solution ID: GM4SG
- PubMed Identifier: 29453613
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- NATURAL PRODUCTS AND BIOPROSPECTING
- Schlüsselwörter
- Antioxidant activity
- Cytotoxicity
- Pharmacognosy
- Plant extract
- Paginierung
- 97 - 105
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan
- Sub types
- Article
- Ausgabe der Zeitschrift
- 8
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Manar Adam
- Gihan OM Elhassan
- Sakina Yagi
- Fatma Sezer Senol
- Ilkay Erdogan Orhan
- Abdel Azim Ahmed
- Thomas Efferth
- DOI
- 10.1007/s13659-018-0155-0
- eISSN
- 2192-2209
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Natural Products and Bioprospecting
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 97 - 105
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s13659-018-0155-0
- Datum der Datenerfassung
- 2023
- Titel
- In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan
- Ausgabe der Zeitschrift
- 8
Data source: Crossref
- Abstract
- We investigated the antioxidant potential and cytotoxicity towards human CCRF-CEM leukemia cells of 57 extracts obtained from 18 plants collected in the Erkowit region, eastern Sudan. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N-dimethyl-p-phenylendiamine (DMPD), metal-chelation capacity, ferric-reducing (FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) methods using ELISA microtiter assays. Total phenol and flavonoid amounts of the extracts were determined spectrophotometrically. Cytotoxicity towards CCRF-CEM cells was evaluated by the resazurin reduction assay. Geranium favosum followed by Kalanchoe glaucescens, Malva parviflora, Aizoon canariense, and Coleus barbatus, respectively, possessed the highest antioxidant activity among the studied plants. Chrozophora oblongifolia and K. glaucescens exerted considerable cytotoxicity against CCRF-CEM leukemia cells. These plants may serve as source for the further development of natural antioxidant and antitumor agents.
- Addresses
- Department of Botany, Faculty of Science, University of Khartoum, Khartoum, Sudan.
- Autoren
- Manar Adam
- Gihan OM Elhassan
- Sakina Yagi
- Fatma Sezer Senol
- Ilkay Erdogan Orhan
- Abdel Azim Ahmed
- Thomas Efferth
- DOI
- 10.1007/s13659-018-0155-0
- eISSN
- 2192-2209
- Externe Identifier
- PubMed Identifier: 29453613
- PubMed Central ID: PMC5913048
- Funding acknowledgements
- Deutscher Akademischer Austauschdienst:
- Open access
- true
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Natural products and bioprospecting
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Open access status
- Open Access
- Paginierung
- 97 - 105
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2018
- Titel
- In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 8
Files
https://link.springer.com/content/pdf/10.1007%2Fs13659-018-0155-0.pdf https://europepmc.org/articles/PMC5913048?pdf=render
Data source: Europe PubMed Central
- Abstract
- We investigated the antioxidant potential and cytotoxicity towards human CCRF-CEM leukemia cells of 57 extracts obtained from 18 plants collected in the Erkowit region, eastern Sudan. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N-dimethyl-p-phenylendiamine (DMPD), metal-chelation capacity, ferric-reducing (FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) methods using ELISA microtiter assays. Total phenol and flavonoid amounts of the extracts were determined spectrophotometrically. Cytotoxicity towards CCRF-CEM cells was evaluated by the resazurin reduction assay. Geranium favosum followed by Kalanchoe glaucescens, Malva parviflora, Aizoon canariense, and Coleus barbatus, respectively, possessed the highest antioxidant activity among the studied plants. Chrozophora oblongifolia and K. glaucescens exerted considerable cytotoxicity against CCRF-CEM leukemia cells. These plants may serve as source for the further development of natural antioxidant and antitumor agents.
- Date of acceptance
- 2018
- Autoren
- Manar Adam
- Gihan OM Elhassan
- Sakina Yagi
- Fatma Sezer Senol
- Ilkay Erdogan Orhan
- Abdel Azim Ahmed
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29453613
- DOI
- 10.1007/s13659-018-0155-0
- Externe Identifier
- PubMed Central ID: PMC5913048
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 2
- Zeitschrift
- Nat Prod Bioprospect
- Schlüsselwörter
- Antioxidant activity
- Cytotoxicity
- Pharmacognosy
- Plant extract
- Sprache
- eng
- Country
- Germany
- Paginierung
- 97 - 105
- PII
- 10.1007/s13659-018-0155-0
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 8
Data source: PubMed
- Beziehungen:
- Property of