Cytotoxic flavonoids from two Lonchocarpus species
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Fozia A Adem
- Victor Kuete
- Armelle T Mbaveng
- Matthias Heydenreich
- Andreas Koch
- Albert Ndakala
- Beatrice Irungu
- Abiy Yenesew
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000475501100004&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/14786419.2018.1462179
- eISSN
- 1478-6427
- Externe Identifier
- Clarivate Analytics Document Solution ID: II9FJ
- PubMed Identifier: 29656660
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- NATURAL PRODUCT RESEARCH
- Schlüsselwörter
- Lonchocarpus bussei
- Lonchocarpus eriocalyx
- Leguminosae
- isoflavone
- pterocarpan
- cytotoxicity
- Paginierung
- 2609 - 2617
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- Cytotoxic flavonoids from two <i>Lonchocarpus</i> species
- Sub types
- Article
- Ausgabe der Zeitschrift
- 33
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Fozia A Adem
- Victor Kuete
- Armelle T Mbaveng
- Matthias Heydenreich
- Andreas Koch
- Albert Ndakala
- Beatrice Irungu
- Abiy Yenesew
- Thomas Efferth
- DOI
- 10.1080/14786419.2018.1462179
- eISSN
- 1478-6427
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Natural Product Research
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 2609 - 2617
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/14786419.2018.1462179
- Datum der Datenerfassung
- 2020
- Titel
- Cytotoxic flavonoids from two <i>Lonchocarpus</i> species
- Ausgabe der Zeitschrift
- 33
Data source: Crossref
- Abstract
- A new isoflavone, 4'-prenyloxyvigvexin A (<b>1</b>) and a new pterocarpan, (6a<i>R</i>,11a<i>R</i>)-3,8-dimethoxybitucarpin B (<b>2</b>) were isolated from the leaves of <i>Lonchocarpus bussei</i> and the stem bark of <i>Lonchocarpus eriocalyx</i>, respectively. The extract of <i>L. bussei</i> also gave four known isoflavones, maximaisoflavone H, 7,2'-dimethoxy-3',4'-methylenedioxyisoflavone, 6,7,3'-trimethoxy-4',5'-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6a<i>R</i>,11a<i>R</i>)-maackiain and (6a<i>R</i>,11a<i>R</i>)-edunol. (6a<i>R</i>,11a<i>R</i>)-Edunol was also isolated from the stem bark of <i>L. eriocalyx</i>. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC<sub>50</sub> values below 10 μM were observed for the isoflavones 6,7,3'-trimethoxy-4',5'-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/<i>BCRP</i> cells and resistant gliobastoma U87MG<i>.</i>Δ<i>EGFR</i> cells.
- Addresses
- a Department of Chemistry , University of Nairobi , Nairobi , Kenya.
- Autoren
- Fozia A Adem
- Victor Kuete
- Armelle T Mbaveng
- Matthias Heydenreich
- Andreas Koch
- Albert Ndakala
- Beatrice Irungu
- Abiy Yenesew
- Thomas Efferth
- Thomas Efferth
- DOI
- 10.1080/14786419.2018.1462179
- eISSN
- 1478-6427
- Externe Identifier
- PubMed Identifier: 29656660
- Funding acknowledgements
- International Science Program: KEN 02
- Open access
- false
- ISSN
- 1478-6419
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Natural product research
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Fabaceae
- Breast Neoplasms
- Benzopyrans
- Flavonoids
- Flavones
- Isoflavones
- Antineoplastic Agents, Phytogenic
- Drug Screening Assays, Antitumor
- Molecular Structure
- Drug Resistance, Neoplasm
- Female
- Hep G2 Cells
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 2609 - 2617
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- Cytotoxic flavonoids from two <i>Lonchocarpus</i> species.
- Sub types
- Video-Audio Media
- Journal Article
- Ausgabe der Zeitschrift
- 33
Data source: Europe PubMed Central
- Abstract
- A new isoflavone, 4'-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2'-dimethoxy-3',4'-methylenedioxyisoflavone, 6,7,3'-trimethoxy-4',5'-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3'-trimethoxy-4',5'-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells.
- Autoren
- Fozia A Adem
- Victor Kuete
- Armelle T Mbaveng
- Matthias Heydenreich
- Andreas Koch
- Albert Ndakala
- Beatrice Irungu
- Abiy Yenesew
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29656660
- DOI
- 10.1080/14786419.2018.1462179
- eISSN
- 1478-6427
- Ausgabe der Veröffentlichung
- 18
- Zeitschrift
- Nat Prod Res
- Schlüsselwörter
- Leguminosae
- cytotoxicity
- isoflavone
- pterocarpan
- Antineoplastic Agents, Phytogenic
- Benzopyrans
- Breast Neoplasms
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Fabaceae
- Female
- Flavones
- Flavonoids
- Hep G2 Cells
- Humans
- Isoflavones
- Molecular Structure
- Sprache
- eng
- Country
- England
- Paginierung
- 2609 - 2617
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2019
- Titel
- Cytotoxic flavonoids from two Lonchocarpus species.
- Sub types
- Journal Article
- Video-Audio Media
- Ausgabe der Zeitschrift
- 33
Data source: PubMed
- Beziehungen:
- Property of