Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana

Publication type:
Journal article
Metadata:
Autoren
  • Fozia A Adem
  • Victor Kuete
  • Armelle T Mbaveng
  • Matthias Heydenreich
  • Albert Ndakala
  • Beatrice Irungu
  • Thomas Efferth
  • Abiy Yenesew
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000437076200005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.fitote.2018.04.019
eISSN
1873-6971
Externe Identifier
  • Clarivate Analytics Document Solution ID: GL3WY
  • PubMed Identifier: 29715541
ISSN
0367-326X
Zeitschrift
FITOTERAPIA
Schlüsselwörter
  • Dorstenia kameruniana
  • Moraceae
  • Benzylbenzofuran
  • Furanocoumarin
  • Chalcone
  • Cytotoxicity
Paginierung
26 - 30
Datum der Veröffentlichung
2018
Status
Published
Titel
Cytotoxic benzylbenzofuran derivatives from <i>Dorstenia kameruniana</i>
Sub types
  • Article
Ausgabe der Zeitschrift
128

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Fozia A Adem
  • Victor Kuete
  • Armelle T Mbaveng
  • Matthias Heydenreich
  • Albert Ndakala
  • Beatrice Irungu
  • Thomas Efferth
  • Abiy Yenesew
DOI
10.1016/j.fitote.2018.04.019
ISSN
0367-326X
Zeitschrift
Fitoterapia
Sprache
en
Paginierung
26 - 30
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.fitote.2018.04.019
Datum der Datenerfassung
2019
Titel
Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana
Ausgabe der Zeitschrift
128

Data source: Crossref

Abstract
Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol(3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1-4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC<sub>50</sub> values of 7.17 μM and 5.16 μM, respectively) against CCRF-CEM leukemia cells. Compound 5 also showed cytotoxicity against 7 sensitive or drug-resistant solid tumor cell lines (breast carcinoma, colon carcinoma, glioblastoma), with IC<sub>50</sub> below 50 μM, whilst 4 showed selective activity.
Addresses
  • Department of Chemistry, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya.
Autoren
  • Fozia A Adem
  • Victor Kuete
  • Armelle T Mbaveng
  • Matthias Heydenreich
  • Albert Ndakala
  • Beatrice Irungu
  • Thomas Efferth
  • Abiy Yenesew
DOI
10.1016/j.fitote.2018.04.019
eISSN
1873-6971
Externe Identifier
  • PubMed Identifier: 29715541
Funding acknowledgements
  • German Academic Exchange Service:
  • Alexander von Humboldt Foundation:
Open access
false
ISSN
0367-326X
Zeitschrift
Fitoterapia
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Moraceae
  • Benzofurans
  • Antineoplastic Agents, Phytogenic
  • Drug Resistance, Multiple
  • Molecular Structure
  • Drug Resistance, Neoplasm
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
26 - 30
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
128

Data source: Europe PubMed Central

Abstract
Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol(3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1-4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC50 values of 7.17 μM and 5.16 μM, respectively) against CCRF-CEM leukemia cells. Compound 5 also showed cytotoxicity against 7 sensitive or drug-resistant solid tumor cell lines (breast carcinoma, colon carcinoma, glioblastoma), with IC50 below 50 μM, whilst 4 showed selective activity.
Date of acceptance
2018
Autoren
  • Fozia A Adem
  • Victor Kuete
  • Armelle T Mbaveng
  • Matthias Heydenreich
  • Albert Ndakala
  • Beatrice Irungu
  • Thomas Efferth
  • Abiy Yenesew
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29715541
DOI
10.1016/j.fitote.2018.04.019
eISSN
1873-6971
Zeitschrift
Fitoterapia
Schlüsselwörter
  • Benzylbenzofuran
  • Chalcone
  • Cytotoxicity
  • Dorstenia kameruniana
  • Furanocoumarin
  • Moraceae
  • Antineoplastic Agents, Phytogenic
  • Benzofurans
  • Cell Line, Tumor
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Humans
  • Molecular Structure
  • Moraceae
Sprache
eng
Country
Netherlands
Paginierung
26 - 30
PII
S0367-326X(18)30332-0
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
128

Data source: PubMed

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