Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Aysun Capci Karagoez
- Christoph Reiter
- Ean-Jeong Seo
- Lisa Gruber
- Friedrich Hahn
- Maria Leidenberger
- Volker Klein
- Frank Hampel
- Oliver Friedrich
- Manfred Marschall
- Barbara Kappes
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000436779400049&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.bmc.2018.05.041
- eISSN
- 1464-3391
- Externe Identifier
- Clarivate Analytics Document Solution ID: GL0LQ
- PubMed Identifier: 29887512
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- BIOORGANIC & MEDICINAL CHEMISTRY
- Schlüsselwörter
- Natural product hybrid
- Artemisinin
- Thymoquinone
- Egonol
- Antileukemia activity
- Antimalarial activity
- Antiviral activity
- Paginierung
- 3610 - 3618
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin
- Sub types
- Article
- Ausgabe der Zeitschrift
- 26
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Aysun Çapcı Karagöz
- Christoph Reiter
- Ean-Jeong Seo
- Lisa Gruber
- Friedrich Hahn
- Maria Leidenberger
- Volker Klein
- Frank Hampel
- Oliver Friedrich
- Manfred Marschall
- Barbara Kappes
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.bmc.2018.05.041
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Bioorganic & Medicinal Chemistry
- Sprache
- en
- Paginierung
- 3610 - 3618
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.bmc.2018.05.041
- Datum der Datenerfassung
- 2019
- Titel
- Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin
- Ausgabe der Zeitschrift
- 26
Data source: Crossref
- Abstract
- Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquinone and artemisinin and evaluation of their activities against P. falciparum 3D7 parasites, human cytomegalovirus, sensitive and multidrug-resistant human leukemia cells. Most of the new hybrids exceed their parent compounds in antimalarial, antiviral and antileukemia activities and in some cases show higher in vitro efficacy than clinically used reference drugs chloroquine, ganciclovir and doxorubicin. Combined, our findings stress the high potency of these hybrids and encourages further use of the hybridization concept in applied pharmacological research.
- Addresses
- Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany.
- Autoren
- Aysun Çapcı Karagöz
- Christoph Reiter
- Ean-Jeong Seo
- Lisa Gruber
- Friedrich Hahn
- Maria Leidenberger
- Volker Klein
- Frank Hampel
- Oliver Friedrich
- Manfred Marschall
- Barbara Kappes
- Thomas Efferth
- Svetlana B Tsogoeva
- DOI
- 10.1016/j.bmc.2018.05.041
- eISSN
- 1464-3391
- Externe Identifier
- PubMed Identifier: 29887512
- Funding acknowledgements
- German Academic Exchange Service DAAD:
- Deutsche Forschungsgemeinschaft: MA 1289/7-3
- Open access
- false
- ISSN
- 0968-0896
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Bioorganic & medicinal chemistry
- Schlüsselwörter
- Cell Line, Tumor
- Animals
- Humans
- Plasmodium falciparum
- Cytomegalovirus
- Anisoles
- Artemisinins
- Benzoquinones
- Benzofurans
- Antineoplastic Agents
- Biological Products
- Antimalarials
- Antiviral Agents
- Crystallography, X-Ray
- Cell Survival
- Molecular Conformation
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 3610 - 3618
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
- Sub types
- Research Support, Non-U.S. Gov't
- Journal Article
- Ausgabe der Zeitschrift
- 26
Data source: Europe PubMed Central
- Abstract
- Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquinone and artemisinin and evaluation of their activities against P. falciparum 3D7 parasites, human cytomegalovirus, sensitive and multidrug-resistant human leukemia cells. Most of the new hybrids exceed their parent compounds in antimalarial, antiviral and antileukemia activities and in some cases show higher in vitro efficacy than clinically used reference drugs chloroquine, ganciclovir and doxorubicin. Combined, our findings stress the high potency of these hybrids and encourages further use of the hybridization concept in applied pharmacological research.
- Date of acceptance
- 2018
- Autoren
- Aysun Çapcı Karagöz
- Christoph Reiter
- Ean-Jeong Seo
- Lisa Gruber
- Friedrich Hahn
- Maria Leidenberger
- Volker Klein
- Frank Hampel
- Oliver Friedrich
- Manfred Marschall
- Barbara Kappes
- Thomas Efferth
- Svetlana B Tsogoeva
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29887512
- DOI
- 10.1016/j.bmc.2018.05.041
- eISSN
- 1464-3391
- Ausgabe der Veröffentlichung
- 12
- Zeitschrift
- Bioorg Med Chem
- Schlüsselwörter
- Antileukemia activity
- Antimalarial activity
- Antiviral activity
- Artemisinin
- Egonol
- Natural product hybrid
- Thymoquinone
- Animals
- Anisoles
- Antimalarials
- Antineoplastic Agents
- Antiviral Agents
- Artemisinins
- Benzofurans
- Benzoquinones
- Biological Products
- Cell Line, Tumor
- Cell Survival
- Crystallography, X-Ray
- Cytomegalovirus
- Humans
- Molecular Conformation
- Plasmodium falciparum
- Sprache
- eng
- Country
- England
- Paginierung
- 3610 - 3618
- PII
- S0968-0896(18)30700-4
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Ausgabe der Zeitschrift
- 26
Data source: PubMed
- Beziehungen:
- Property of