Prevention of carcinogenesis and metastasis by Artemisinin-type drugs

Publication type:
Journal article
Metadata:
Autoren
  • Mohammed L Abba
  • Nitin Patil
  • Joerg Hendrik Leupold
  • Mohamed EM Saeed
  • Thomas Efferth
  • Heike Allgayer
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000454183600002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.canlet.2018.05.008
eISSN
1872-7980
Externe Identifier
  • Clarivate Analytics Document Solution ID: HF4DO
  • PubMed Identifier: 29746932
ISSN
0304-3835
Zeitschrift
CANCER LETTERS
Schlüsselwörter
  • Artemisia annua L.
  • Asterateae
  • Cancer
  • Carcinogenesis
  • Initation
  • Metastasis
  • Prevention
  • Progression
Paginierung
11 - 18
Datum der Veröffentlichung
2018
Status
Published
Titel
Prevention of carcinogenesis and metastasis by Artemisinin-type drugs
Sub types
  • Article
Ausgabe der Zeitschrift
429

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Mohammed L Abba
  • Nitin Patil
  • Jörg Hendrik Leupold
  • Mohamed EM Saeed
  • Thomas Efferth
  • Heike Allgayer
DOI
10.1016/j.canlet.2018.05.008
ISSN
0304-3835
Zeitschrift
Cancer Letters
Sprache
en
Paginierung
11 - 18
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.canlet.2018.05.008
Datum der Datenerfassung
2020
Titel
Prevention of carcinogenesis and metastasis by Artemisinin-type drugs
Ausgabe der Zeitschrift
429

Data source: Crossref

Abstract
Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard therapies against malaria worldwide, and its discovery has led to the Nobel Prize in Physiology and Medicine to Youyou Tu in 2015. While most attention has been paid to the treatment of malaria, there is increasing evidence that Artemisinin-type drugs bear a considerable potential to treat and prevent cancer. Rather than reporting on therapy of cancer, this review gives a comprehensive and timely overview on the chemopreventive effects of artemisinin and its derivatives against carcinogenesis and metastasis formation, following the multistage model of carcinogenesis (initiation, promotion, progression). The favorable toxicity profile known from malaria studies indicates that artemisinin-type drugs may be safely applied to prevent carcinogenesis and cancer metastasis in human beings.
Addresses
  • Department of Experimental Surgery - Cancer Metastasis, Medical Faculty Mannheim, Center for Biomedicine and Medical Technology Mannheim (CBTM), Ludolf-Krehl-Str. 6, 68135 Mannheim, Ruprecht-Karls University of Heidelberg, Germany.
Autoren
  • Mohammed L Abba
  • Nitin Patil
  • Jörg Hendrik Leupold
  • Mohamed EM Saeed
  • Thomas Efferth
  • Heike Allgayer
DOI
10.1016/j.canlet.2018.05.008
eISSN
1872-7980
Externe Identifier
  • PubMed Identifier: 29746932
Funding acknowledgements
  • Alfried Krupp von Bohlen und Halbach Foundation, Essen:
  • DKFZ-MOST Cooperation, Heidelberg: CA149
  • Molecular Biomarkers for Individualized Therapy (MoBIT):
  • HIPO/POP-Initiative for Personalized Oncology, Heidelberg: H027
  • Dr Hella-Buehler-Foundation, Heidelberg:
  • HEiKA Initiative:
  • Medical Faculty Mannheim of the University of Heidelberg (MEAMEDMA):
  • HIPO/POP-Initiative for Personalized Oncology, Heidelberg: H032
  • Deutsche Krebshilfe, Bonn: 70112168
  • Deutsche Forschungsgemeinschaft: AL 465/9-1
  • HIPO/POP Initiative:
  • Ingrid zu Solms Foundation, Frankfurt:
Open access
false
ISSN
0304-3835
Zeitschrift
Cancer letters
Schlüsselwörter
  • Humans
  • Artemisia annua
  • Neoplasms
  • Neoplasm Metastasis
  • Artemisinins
  • Antimalarials
  • Phytotherapy
  • Molecular Structure
  • Clinical Trials as Topic
  • Carcinogenesis
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
11 - 18
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
Prevention of carcinogenesis and metastasis by Artemisinin-type drugs.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
429

Data source: Europe PubMed Central

Abstract
Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard therapies against malaria worldwide, and its discovery has led to the Nobel Prize in Physiology and Medicine to Youyou Tu in 2015. While most attention has been paid to the treatment of malaria, there is increasing evidence that Artemisinin-type drugs bear a considerable potential to treat and prevent cancer. Rather than reporting on therapy of cancer, this review gives a comprehensive and timely overview on the chemopreventive effects of artemisinin and its derivatives against carcinogenesis and metastasis formation, following the multistage model of carcinogenesis (initiation, promotion, progression). The favorable toxicity profile known from malaria studies indicates that artemisinin-type drugs may be safely applied to prevent carcinogenesis and cancer metastasis in human beings.
Date of acceptance
2018
Autoren
  • Mohammed L Abba
  • Nitin Patil
  • Jörg Hendrik Leupold
  • Mohamed EM Saeed
  • Thomas Efferth
  • Heike Allgayer
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/29746932
DOI
10.1016/j.canlet.2018.05.008
eISSN
1872-7980
Zeitschrift
Cancer Lett
Schlüsselwörter
  • Artemisia annua L.
  • Asteraceae
  • Cancer
  • Carcinogenesis
  • Initation
  • Metastasis
  • Prevention
  • Progression
  • Antimalarials
  • Artemisia annua
  • Artemisinins
  • Carcinogenesis
  • Clinical Trials as Topic
  • Humans
  • Molecular Structure
  • Neoplasm Metastasis
  • Neoplasms
  • Phytotherapy
Sprache
eng
Country
Ireland
Paginierung
11 - 18
PII
S0304-3835(18)30327-6
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Prevention of carcinogenesis and metastasis by Artemisinin-type drugs.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
429

Data source: PubMed

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