2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Peng Wang
- Chang Gao
- Na Guo
- Sun-Dong Zhang
- Wei Wang
- Li-Ping Yao
- Jing Zhang
- Thomas Efferth
- Yu-Jie Fu
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000436459100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3389/fphar.2018.00679
- Externe Identifier
- Clarivate Analytics Document Solution ID: GK8GZ
- PubMed Identifier: 29997508
- ISSN
- 1663-9812
- Zeitschrift
- FRONTIERS IN PHARMACOLOGY
- Schlüsselwörter
- NF-kappa B
- SIRT1
- anti-inflammation
- 2 '-O-galloylhyperin
- Nrf2
- Artikelnummer
- ARTN 679
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- 2′-<i>O</i>-Galloylhyperin Isolated From <i>Pyrola incarnata</i> Fisch Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways <i>in Vitro</i> and <i>Vivo</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 9
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Peng Wang
- Chang Gao
- Na Guo
- Sun-Dong Zhang
- Wei Wang
- Li-Ping Yao
- Jing Zhang
- Thomas Efferth
- Yu-Jie Fu
- DOI
- 10.3389/fphar.2018.00679
- eISSN
- 1663-9812
- Zeitschrift
- Frontiers in Pharmacology
- Online publication date
- 2018
- Status
- Published online
- Herausgeber
- Frontiers Media SA
- Herausgeber URL
- http://dx.doi.org/10.3389/fphar.2018.00679
- Datum der Datenerfassung
- 2018
- Titel
- 2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo
- Ausgabe der Zeitschrift
- 9
Data source: Crossref
- Abstract
- 2'-<i>O</i>-galloylhyperin, a major compound of <i>Pyrola incarnata</i> Fisch., possesses a variety of biological and pharmacological activities, including anti-oxidative and anti-inflammatory activities. Nevertheless, the underlying molecular mechanisms of 2<i>'-O</i>-GH in microbial infection and sepsis are not clear. In this study, we investigated the anti-inflammatory effects of 2<i>'-O</i>-GH. We found that 2<i>'-O</i>-GH significantly reduced the production of TNF-α, IL-6, and nitric oxide (NO), suppressed the expression levels of iNOS, blocked the translocation of NF-κB from the cytosol to nucleus, and decreased the MAPK activation in LPS-activated RAW 264.7 cells. 2<i>'-O</i>-GH also enhanced the nuclear translocation of Nrf2 and up-regulated the expression of heme oxygenase-1 (HO-1) and SIRT1. In addition, the administration of 2<i>'-O</i>-GH attenuated the TNF-α and IL-6 production in the serum, infiltration of inflammatory cells, liver tissue damage, and the mortality rate of LPS-challenged mice. Moreover, 2<i>'-O</i>-GH significantly upregulated Nrf2 and SIRT1 expression and inhibited the inflammatory responses in the liver of septic mice. The collective data indicate that 2<i>'-O</i>-GH could potentially be a novel functional food candidate in the treatment of sepsis.
- Addresses
- Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, China.
- Autoren
- Peng Wang
- Chang Gao
- Na Guo
- Sun-Dong Zhang
- Wei Wang
- Li-Ping Yao
- Jing Zhang
- Thomas Efferth
- Yu-Jie Fu
- DOI
- 10.3389/fphar.2018.00679
- eISSN
- 1663-9812
- Externe Identifier
- PubMed Identifier: 29997508
- PubMed Central ID: PMC6030669
- Open access
- true
- ISSN
- 1663-9812
- Zeitschrift
- Frontiers in pharmacology
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2018
- Open access status
- Open Access
- Paginierung
- 679
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2018
- Titel
- 2'-<i>O</i>-Galloylhyperin Isolated From <i>Pyrola incarnata</i> Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways <i>in Vitro</i> and <i>Vivo</i>.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 9
Files
https://www.frontiersin.org/articles/10.3389/fphar.2018.00679/pdf https://europepmc.org/articles/PMC6030669?pdf=render
Data source: Europe PubMed Central
- Abstract
- 2'-O-galloylhyperin, a major compound of Pyrola incarnata Fisch., possesses a variety of biological and pharmacological activities, including anti-oxidative and anti-inflammatory activities. Nevertheless, the underlying molecular mechanisms of 2'-O-GH in microbial infection and sepsis are not clear. In this study, we investigated the anti-inflammatory effects of 2'-O-GH. We found that 2'-O-GH significantly reduced the production of TNF-α, IL-6, and nitric oxide (NO), suppressed the expression levels of iNOS, blocked the translocation of NF-κB from the cytosol to nucleus, and decreased the MAPK activation in LPS-activated RAW 264.7 cells. 2'-O-GH also enhanced the nuclear translocation of Nrf2 and up-regulated the expression of heme oxygenase-1 (HO-1) and SIRT1. In addition, the administration of 2'-O-GH attenuated the TNF-α and IL-6 production in the serum, infiltration of inflammatory cells, liver tissue damage, and the mortality rate of LPS-challenged mice. Moreover, 2'-O-GH significantly upregulated Nrf2 and SIRT1 expression and inhibited the inflammatory responses in the liver of septic mice. The collective data indicate that 2'-O-GH could potentially be a novel functional food candidate in the treatment of sepsis.
- Date of acceptance
- 2018
- Autoren
- Peng Wang
- Chang Gao
- Na Guo
- Sun-Dong Zhang
- Wei Wang
- Li-Ping Yao
- Jing Zhang
- Thomas Efferth
- Yu-Jie Fu
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/29997508
- DOI
- 10.3389/fphar.2018.00679
- Externe Identifier
- PubMed Central ID: PMC6030669
- ISSN
- 1663-9812
- Zeitschrift
- Front Pharmacol
- Schlüsselwörter
- 2′-O-galloylhyperin
- NF-κB
- Nrf2
- SIRT1
- anti-inflammation
- Sprache
- eng
- Country
- Switzerland
- Paginierung
- 679
- Datum der Veröffentlichung
- 2018
- Status
- Published online
- Titel
- 2'-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 9
Data source: PubMed
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- Property of