The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior

Publication type:
Journal article
Metadata:
Autoren
  • Eman Ali Abd El-Ghffar
  • Eman Al-Sayed
  • Safia Mohamed Shehata
  • Omayma A Eldahshan
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000449820900038&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/c8fo00538a
eISSN
2042-650X
Externe Identifier
  • Clarivate Analytics Document Solution ID: GZ9LM
  • PubMed Identifier: 30073231
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
FOOD & FUNCTION
Paginierung
4457 - 4468
Datum der Veröffentlichung
2018
Status
Published
Titel
The protective role of <i>Ocimum basilicum</i> L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior
Sub types
  • Article
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<p>The gastroprotective effect of<italic>Ocimum basilicum</italic>L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined.</p>
Autoren
  • Eman Ali Abd El-Ghffar
  • Eman Al-Sayed
  • Safia Mohamed Shehata
  • Omayma A Eldahshan
  • Thomas Efferth
DOI
10.1039/c8fo00538a
eISSN
2042-650X
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
Food &amp; Function
Sprache
en
Online publication date
2018
Paginierung
4457 - 4468
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/c8fo00538a
Datum der Datenerfassung
2024
Titel
The protective role of<i>Ocimum basilicum</i>L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined. Pretreatment with OBHE (100 or 200 mg kg-1) or misoprostol (50 μg kg-1) alleviated the aspirin-induced oxidative stress by significantly decreasing (p < 0.001) gastric ulcer index scores (57, 76 and 79%), gastric TBARS (by 49, 51 and 52%), NO (21, 28 and 29%), H2O2 (24, 42 and 45%), and the serum pro-inflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34%), GST (33, 63 and 70%), GR (90, 99 and 112%), CAT (167, 211 and 267%) and serum PGE-2 levels (22, 135 and 200%) and IL-4 (64, 81 and 104%), respectively, compared with the aspirin-treated group. Meanwhile, OBHE and misoprostol induced a significant decrease (p < 0.001) in the freezing time (53, 56 and 64%), and the grooming time (by 25, 43 and 44%), respectively, compared to the aspirin treated group. This study provides evidence that OBHE confers anxiolytic, antioxidant and anti-inflammatory prophylactic effects on aspirin-induced gastric ulcers. GC/MS was used for the characterization of OBHE components. Based on the findings of this study, basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers, a common problem resulting from the use of aspirin.
Addresses
  • Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.
Autoren
  • Eman Ali Abd El-Ghffar
  • Eman Al-Sayed
  • Safia Mohamed Shehata
  • Omayma A Eldahshan
  • Thomas Efferth
DOI
10.1039/c8fo00538a
eISSN
2042-650X
Externe Identifier
  • PubMed Identifier: 30073231
Open access
false
ISSN
2042-6496
Ausgabe der Veröffentlichung
8
Zeitschrift
Food & function
Schlüsselwörter
  • Animals
  • Humans
  • Mice
  • Ocimum basilicum
  • Plant Leaves
  • Stomach Ulcer
  • Aspirin
  • Tumor Necrosis Factor-alpha
  • Plant Extracts
  • Interleukin-4
  • Interleukin-6
  • Protective Agents
  • Behavior, Animal
  • Motor Activity
  • Anxiety
  • Oxidative Stress
  • Female
  • Male
Sprache
eng
Medium
Print
Paginierung
4457 - 4468
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: Europe PubMed Central

Abstract
The gastroprotective effect of Ocimum basilicum L. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined. Pretreatment with OBHE (100 or 200 mg kg-1) or misoprostol (50 μg kg-1) alleviated the aspirin-induced oxidative stress by significantly decreasing (p < 0.001) gastric ulcer index scores (57, 76 and 79%), gastric TBARS (by 49, 51 and 52%), NO (21, 28 and 29%), H2O2 (24, 42 and 45%), and the serum pro-inflammatory mediator TNF-α (21, 53 and 53%) and IL-6 (29, 30 and 31%), as well as by markedly increasing gastric GSH (41, 61 and 70%), GSH-Px (21, 32 and 34%), GST (33, 63 and 70%), GR (90, 99 and 112%), CAT (167, 211 and 267%) and serum PGE-2 levels (22, 135 and 200%) and IL-4 (64, 81 and 104%), respectively, compared with the aspirin-treated group. Meanwhile, OBHE and misoprostol induced a significant decrease (p < 0.001) in the freezing time (53, 56 and 64%), and the grooming time (by 25, 43 and 44%), respectively, compared to the aspirin treated group. This study provides evidence that OBHE confers anxiolytic, antioxidant and anti-inflammatory prophylactic effects on aspirin-induced gastric ulcers. GC/MS was used for the characterization of OBHE components. Based on the findings of this study, basil may be used as a nutritional supplement or therapeutic drug to protect against aspirin-induced gastric ulcers, a common problem resulting from the use of aspirin.
Autoren
  • Eman Ali Abd El-Ghffar
  • Eman Al-Sayed
  • Safia Mohamed Shehata
  • Omayma A Eldahshan
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30073231
DOI
10.1039/c8fo00538a
eISSN
2042-650X
Ausgabe der Veröffentlichung
8
Zeitschrift
Food Funct
Schlüsselwörter
  • Animals
  • Anxiety
  • Aspirin
  • Behavior, Animal
  • Female
  • Humans
  • Interleukin-4
  • Interleukin-6
  • Male
  • Mice
  • Motor Activity
  • Ocimum basilicum
  • Oxidative Stress
  • Plant Extracts
  • Plant Leaves
  • Protective Agents
  • Stomach Ulcer
  • Tumor Necrosis Factor-alpha
Sprache
eng
Country
England
Paginierung
4457 - 4468
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
The protective role of Ocimum basilicum L. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: PubMed

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