Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Ali M El-Halawany
- Taha A Hussien
- Sara Abdelfatah
- Shinji Ohta
- Paul W Pare
- Essam Abdel-Sattar
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000449129500009&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.fitote.2018.08.002
- eISSN
- 1873-6971
- Externe Identifier
- Clarivate Analytics Document Solution ID: GZ1LL
- PubMed Identifier: 30114467
- ISSN
- 0367-326X
- Zeitschrift
- FITOTERAPIA
- Schlüsselwörter
- Salvia multicaulis
- Lamiaceae
- Abietane diterpenoids
- Cytotoxic activity
- Multidrug resistance
- Paginierung
- 54 - 60
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- Cytotoxicity of abietane diterpenoids from <i>Salvia multicaulis</i> towards multidrug-resistant cancer cells
- Sub types
- Article
- Ausgabe der Zeitschrift
- 130
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Ali M El-Halawany
- Taha A Hussien
- Sara Abdelfatah
- Shinji Ohta
- Paul W Paré
- Essam Abdel-Sattar
- Thomas Efferth
- DOI
- 10.1016/j.fitote.2018.08.002
- ISSN
- 0367-326X
- Zeitschrift
- Fitoterapia
- Sprache
- en
- Paginierung
- 54 - 60
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.fitote.2018.08.002
- Datum der Datenerfassung
- 2018
- Titel
- Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells
- Ausgabe der Zeitschrift
- 130
Data source: Crossref
- Abstract
- Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3-6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1-2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC<sub>50</sub> 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Ali M El-Halawany
- Taha A Hussien
- Sara Abdelfatah
- Shinji Ohta
- Paul W Paré
- Essam Abdel-Sattar
- Thomas Efferth
- DOI
- 10.1016/j.fitote.2018.08.002
- eISSN
- 1873-6971
- Externe Identifier
- PubMed Identifier: 30114467
- Funding acknowledgements
- National Research Centre:
- Alexander von Humboldt Foundation:
- German Academic Exchange Service:
- Open access
- false
- ISSN
- 0367-326X
- Zeitschrift
- Fitoterapia
- Schlüsselwörter
- Cell Line, Tumor
- Humans
- Salvia
- Plant Components, Aerial
- Drug Resistance, Multiple
- Molecular Structure
- Drug Resistance, Neoplasm
- Egypt
- Phytochemicals
- Abietanes
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2018
- Paginierung
- 54 - 60
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum der Datenerfassung
- 2018
- Titel
- Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 130
Data source: Europe PubMed Central
- Abstract
- Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3-6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1-2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.
- Date of acceptance
- 2018
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Ali M El-Halawany
- Taha A Hussien
- Sara Abdelfatah
- Shinji Ohta
- Paul W Paré
- Essam Abdel-Sattar
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30114467
- DOI
- 10.1016/j.fitote.2018.08.002
- eISSN
- 1873-6971
- Zeitschrift
- Fitoterapia
- Schlüsselwörter
- Abietane diterpenoids
- Cytotoxic activity
- Lamiaceae
- Multidrug resistance
- Salvia multicaulis
- Abietanes
- Cell Line, Tumor
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Egypt
- Humans
- Molecular Structure
- Phytochemicals
- Plant Components, Aerial
- Salvia
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 54 - 60
- PII
- S0367-326X(18)31089-X
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 130
Data source: PubMed
- Beziehungen:
- Property of