Prevention from radiation damage by natural products

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000442764100020&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2017.11.005
Externe Identifier
  • Clarivate Analytics Document Solution ID: GR6LT
  • PubMed Identifier: 30166104
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Cancer
  • Phytochemical
  • Radiotherapy
  • Radioprotection
  • Side effects
Paginierung
192 - 200
Datum der Veröffentlichung
2018
Status
Published
Titel
Prevention from radiation damage by natural products
Sub types
  • Review
Ausgabe der Zeitschrift
47

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2017.11.005
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Paginierung
192 - 200
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2017.11.005
Datum der Datenerfassung
2020
Titel
Prevention from radiation damage by natural products
Ausgabe der Zeitschrift
47

Data source: Crossref

Abstract
<h4>Background</h4>Radiotherapy is a mainstay of cancer treatment since decades. Ionizing radiation (IR) is used for destruction of cancer cells and shrinkage of tumors. However, the increase of radioresistance in cancer cells and radiation toxicity to normal tissues are severe concerns. The exposure to radiation generates intracellular reactive oxygen species (ROS), which leads to DNA damage by lipid peroxidation, removal of thiol groups from cellular and membrane proteins, strand breaks and base alterations.<h4>Hypothesis</h4>Plants have to deal with radiation-induced damage (UV-light of sun, other natural radiation sources). Therefore, it is worth speculating that radioprotective mechanisms have evolved during evolution of life. We hypothesize that natural products from plants may also protect from radiation damage caused as adverse side effects of cancer radiotherapy.<h4>Methods</h4>The basis of this systematic review, we searched the relevant literature in the PubMed database.<h4>Results</h4>Flavonoids, such as genistein, epigallocatechin-3-gallate, epicatechin, apigenin and silibinin mainly act as antioxidant, free radical scavenging and anti-inflammatory compounds, thus, providing cytoprotection in addition to downregulation of several pro-inflammatory cytokines. Comparable effects have been found in phenylpropanoids, especially caffeic acid phenylethylester, curcumin, thymol and zingerone. Besides, resveratrol and quercetin are the most important cytoprotective polyphenols. Their radioprotective effects are mediated by a wide range of mechanisms mainly leading to direct or indirect reduction of cellular stress. Ascorbic acid is broadly used as antioxidant, but it has also shown activity in reducing cellular damage after irradiation mainly due to its antioxidant capabilities. The metal ion chelator, gallic acid, represents another natural product attenuating cellular damage caused by radiation.<h4>Conclusions</h4>Some secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation. These results warrant further analysis to develop phytochemicals as radioprotectors for clinical use.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
Autoren
DOI
10.1016/j.phymed.2017.11.005
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 30166104
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Plants
  • Neoplasms
  • DNA Damage
  • Radiation Injuries
  • Reactive Oxygen Species
  • Ascorbic Acid
  • Curcumin
  • Stilbenes
  • Flavonoids
  • Antioxidants
  • Radiation-Protective Agents
  • Radiotherapy
  • Lipid Peroxidation
  • Polyphenols
  • Phytochemicals
  • Resveratrol
Sprache
eng
Medium
Print-Electronic
Online publication date
2017
Paginierung
192 - 200
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
Prevention from radiation damage by natural products.
Sub types
  • Systematic Review
  • Review
  • Journal Article
Ausgabe der Zeitschrift
47

Data source: Europe PubMed Central

Abstract
BACKGROUND: Radiotherapy is a mainstay of cancer treatment since decades. Ionizing radiation (IR) is used for destruction of cancer cells and shrinkage of tumors. However, the increase of radioresistance in cancer cells and radiation toxicity to normal tissues are severe concerns. The exposure to radiation generates intracellular reactive oxygen species (ROS), which leads to DNA damage by lipid peroxidation, removal of thiol groups from cellular and membrane proteins, strand breaks and base alterations. HYPOTHESIS: Plants have to deal with radiation-induced damage (UV-light of sun, other natural radiation sources). Therefore, it is worth speculating that radioprotective mechanisms have evolved during evolution of life. We hypothesize that natural products from plants may also protect from radiation damage caused as adverse side effects of cancer radiotherapy. METHODS: The basis of this systematic review, we searched the relevant literature in the PubMed database. RESULTS: Flavonoids, such as genistein, epigallocatechin-3-gallate, epicatechin, apigenin and silibinin mainly act as antioxidant, free radical scavenging and anti-inflammatory compounds, thus, providing cytoprotection in addition to downregulation of several pro-inflammatory cytokines. Comparable effects have been found in phenylpropanoids, especially caffeic acid phenylethylester, curcumin, thymol and zingerone. Besides, resveratrol and quercetin are the most important cytoprotective polyphenols. Their radioprotective effects are mediated by a wide range of mechanisms mainly leading to direct or indirect reduction of cellular stress. Ascorbic acid is broadly used as antioxidant, but it has also shown activity in reducing cellular damage after irradiation mainly due to its antioxidant capabilities. The metal ion chelator, gallic acid, represents another natural product attenuating cellular damage caused by radiation. CONCLUSIONS: Some secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation. These results warrant further analysis to develop phytochemicals as radioprotectors for clinical use.
Date of acceptance
2017
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30166104
DOI
10.1016/j.phymed.2017.11.005
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Cancer
  • Phytochemical
  • Radioprotection
  • Radiotherapy
  • Side effects
  • Antioxidants
  • Ascorbic Acid
  • Curcumin
  • DNA Damage
  • Flavonoids
  • Humans
  • Lipid Peroxidation
  • Neoplasms
  • Phytochemicals
  • Plants
  • Polyphenols
  • Radiation Injuries
  • Radiation-Protective Agents
  • Radiotherapy
  • Reactive Oxygen Species
  • Resveratrol
  • Stilbenes
Sprache
eng
Country
Germany
Paginierung
192 - 200
PII
S0944-7113(17)30167-8
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
Prevention from radiation damage by natural products.
Sub types
  • Journal Article
  • Review
  • Systematic Review
Ausgabe der Zeitschrift
47

Data source: PubMed

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