The activity of Artemisia spp. and their constituents against Trypanosomiasis

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000442764100019&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2018.06.002
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: GR6LT
  • PubMed Identifier: 30166103
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Alkaloids
  • Artemisinin
  • Asteraceae
  • Chemotherapy
  • Coumarins
  • Essential oils
  • Flavonoids
  • Neglected diseases
  • Phytotherapy
  • Terpenoids
Paginierung
184 - 191
Datum der Veröffentlichung
2018
Status
Published
Titel
The activity of <i>Artemisia</i> spp. and their constituents against Trypanosomiasis
Sub types
  • Review
Ausgabe der Zeitschrift
47

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2018.06.002
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Paginierung
184 - 191
Datum der Veröffentlichung
2018
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2018.06.002
Datum der Datenerfassung
2020
Titel
The activity of Artemisia spp. and their constituents against Trypanosomiasis
Ausgabe der Zeitschrift
47

Data source: Crossref

Abstract
<h4>Background</h4>Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects.<h4>Purpose</h4>Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes.<h4>Study design</h4>A PubMed search for "Artemisia/Artemisinin and Trypanosoma" has been conducted for literature until December 2017.<h4>Results</h4>Interestingly, not only A. annua L. and its active principle, artemisinin revealed inhibitory activity towards trypanosomes. Other Artemisia species (A. absinthium, A. abyssinica, A. afra, A. douglasia, A. elegantissima, A. maciverae, A. mexicana, and A. roxburghiana) also inhibited T. brucei, T. cruzi, or T. congolense. The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, dihydroluteolin, dracunculin and bis-dracunculin, helenalin, nepetin, scoparol, scopoletin, stigmasterol, (Z)-p‑hydroxy cinnamic acid, β-sitosterol and others. In addition to artemisinin from A. annua, artemether and artesunate, further novel artemisinin derivatives and nanotechnological preparations may also be useful to combat Trypanosoma infections.<h4>Conclusion</h4>There are numerous results reporting on the anti-trypanosomal activity the genus Artemisia, artemisinin and its derivatives and other phytochemicals from Artemisia species. This field of research is, however, still in its infancy and more intensive research is required to explore the full potential of diverse Artemisia species and their chemical ingredients for eradication of trypanosomal infections.
Addresses
  • Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.
Autoren
DOI
10.1016/j.phymed.2018.06.002
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 30166103
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: DFG GRK 2015/1
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Artemisia
  • Trypanosomiasis
  • Artemisinins
  • Scopoletin
  • Oils, Volatile
  • Plant Extracts
  • Antimalarials
  • Phytochemicals
  • Artesunate
  • Artemether
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
184 - 191
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
The activity of Artemisia spp. and their constituents against Trypanosomiasis.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
47

Data source: Europe PubMed Central

Abstract
BACKGROUND: Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. PURPOSE: Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes. STUDY DESIGN: A PubMed search for "Artemisia/Artemisinin and Trypanosoma" has been conducted for literature until December 2017. RESULTS: Interestingly, not only A. annua L. and its active principle, artemisinin revealed inhibitory activity towards trypanosomes. Other Artemisia species (A. absinthium, A. abyssinica, A. afra, A. douglasia, A. elegantissima, A. maciverae, A. mexicana, and A. roxburghiana) also inhibited T. brucei, T. cruzi, or T. congolense. The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, dihydroluteolin, dracunculin and bis-dracunculin, helenalin, nepetin, scoparol, scopoletin, stigmasterol, (Z)-p‑hydroxy cinnamic acid, β-sitosterol and others. In addition to artemisinin from A. annua, artemether and artesunate, further novel artemisinin derivatives and nanotechnological preparations may also be useful to combat Trypanosoma infections. CONCLUSION: There are numerous results reporting on the anti-trypanosomal activity the genus Artemisia, artemisinin and its derivatives and other phytochemicals from Artemisia species. This field of research is, however, still in its infancy and more intensive research is required to explore the full potential of diverse Artemisia species and their chemical ingredients for eradication of trypanosomal infections.
Date of acceptance
2018
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30166103
DOI
10.1016/j.phymed.2018.06.002
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Alkaloids
  • Artemisinin
  • Asteraceae
  • Chemotherapy
  • Coumarins
  • Essential oils
  • Flavonoids
  • Neglected diseases
  • Phytotherapy
  • Terpenoids
  • Antimalarials
  • Artemether
  • Artemisia
  • Artemisinins
  • Artesunate
  • Oils, Volatile
  • Phytochemicals
  • Plant Extracts
  • Scopoletin
  • Trypanosomiasis
Sprache
eng
Country
Germany
Paginierung
184 - 191
PII
S0944-7113(18)30185-5
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2018
Titel
The activity of Artemisia spp. and their constituents against Trypanosomiasis.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
47

Data source: PubMed

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