Euphosantianane A-D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Mahmoud AA Ibrahim
- Zienab Talat
- Eman H Reda
- Nahla S Abdel-Azim
- Faiza M Hammouda
- Seikou Nakamura
- Hisashi Matsuda
- Eman G Haggag
- Paul W Pare
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000447365100132&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/molecules23092221
- eISSN
- 1420-3049
- Externe Identifier
- Clarivate Analytics Document Solution ID: GW9YP
- PubMed Identifier: 30200407
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- MOLECULES
- Schlüsselwörter
- Euphorbia sanctae-catharinae
- Euphorbiaceae
- diterpenes
- flavonoids
- TDDTF-ECD
- tumor anti-proliferative activity
- Artikelnummer
- ARTN 2221
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Titel
- Euphosantianane A-D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant <i>Euphorbia</i> <i>Sanctae-Catharinae</i>
- Sub types
- Article
- Ausgabe der Zeitschrift
- 23
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.</jats:p>
- Autoren
- Mohamed-Elamir Hegazy
- Ahmed Hamed
- Mahmoud Ibrahim
- Zienab Talat
- Eman Reda
- Nahla Abdel-Azim
- Faiza Hammouda
- Seikou Nakamura
- Hisashi Matsuda
- Eman Haggag
- Paul Paré
- Thomas Efferth
- DOI
- 10.3390/molecules23092221
- eISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Molecules
- Sprache
- en
- Online publication date
- 2018
- Paginierung
- 2221 - 2221
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/molecules23092221
- Datum der Datenerfassung
- 2018
- Titel
- Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
- Ausgabe der Zeitschrift
- 23
Data source: Crossref
- Abstract
- <i>Euphorbia</i> species are rich in diterpenes. A solvent extraction of <i>Euphorbia sanctae-catharinae</i>, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (<b>1</b>⁻<b>4</b>) as well as previously reported metabolites (<b>5</b>⁻<b>13</b>) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound <b>9</b> exhibited robust anti-proliferative activity against A549 cells (IC<sub>50</sub> = 3.3 µM). Absolute configurations for <b>8</b> versus <b>9</b> were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.
- Addresses
- Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. Elamir77@live.com.
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Mahmoud AA Ibrahim
- Zienab Talat
- Eman H Reda
- Nahla S Abdel-Azim
- Nahla S Abdel-Azim
- Faiza M Hammouda
- Seikou Nakamura
- Hisashi Matsuda
- Eman G Haggag
- Paul W Paré
- Thomas Efferth
- DOI
- 10.3390/molecules23092221
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Identifier: 30200407
- PubMed Central ID: PMC6225227
- Funding acknowledgements
- Welch Foundation: D1478
- Science and Technology Development Fund: 7972
- Science and Technology Development Fund: 5480
- Open access
- true
- ISSN
- 1420-3049
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Molecules (Basel, Switzerland)
- Schlüsselwörter
- Caco-2 Cells
- Humans
- Euphorbia
- Diterpenes
- Circular Dichroism
- Inhibitory Concentration 50
- Cell Proliferation
- Proton Magnetic Resonance Spectroscopy
- Carbon-13 Magnetic Resonance Spectroscopy
- A549 Cells
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2018
- Open access status
- Open Access
- Paginierung
- E2221
- Datum der Veröffentlichung
- 2018
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2018
- Titel
- Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant <i>Euphorbia Sanctae-Catharinae</i>.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 23
Files
https://www.mdpi.com/1420-3049/23/9/2221/pdf?version=1535772022 https://europepmc.org/articles/PMC6225227?pdf=render
Data source: Europe PubMed Central
- Abstract
- Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1⁻4) as well as previously reported metabolites (5⁻13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.
- Date of acceptance
- 2018
- Autoren
- Mohamed-Elamir F Hegazy
- Ahmed R Hamed
- Mahmoud AA Ibrahim
- Zienab Talat
- Eman H Reda
- Nahla S Abdel-Azim
- Faiza M Hammouda
- Seikou Nakamura
- Hisashi Matsuda
- Eman G Haggag
- Paul W Paré
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30200407
- DOI
- 10.3390/molecules23092221
- eISSN
- 1420-3049
- Externe Identifier
- PubMed Central ID: PMC6225227
- Funding acknowledgements
- Science and Technology Development Fund: 5480
- Science and Technology Development Fund: 7972
- Welch Foundation: D1478
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Molecules
- Schlüsselwörter
- Euphorbia sanctae-catharinae
- Euphorbiaceae
- TDDTF-ECD
- diterpenes
- flavonoids
- tumor anti-proliferative activity
- A549 Cells
- Caco-2 Cells
- Carbon-13 Magnetic Resonance Spectroscopy
- Cell Proliferation
- Circular Dichroism
- Diterpenes
- Euphorbia
- Humans
- Inhibitory Concentration 50
- Proton Magnetic Resonance Spectroscopy
- Sprache
- eng
- Country
- Switzerland
- PII
- molecules23092221
- Datum der Veröffentlichung
- 2018
- Status
- Published online
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2018
- Titel
- Euphosantianane A⁻D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 23
Data source: PubMed
- Beziehungen:
- Property of