The prophylactic effect of a Eugenia aquea extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000453244900052&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/c8fo01570h
eISSN
2042-650X
Externe Identifier
  • Clarivate Analytics Document Solution ID: HE3HP
  • PubMed Identifier: 30511707
ISSN
2042-6496
Ausgabe der Veröffentlichung
12
Zeitschrift
FOOD & FUNCTION
Paginierung
6644 - 6652
Datum der Veröffentlichung
2018
Status
Published
Titel
The prophylactic effect of a <i>Eugenia aquea</i> extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model
Sub types
  • Article
Ausgabe der Zeitschrift
9

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<p>Rheumatoid arthritis (RA) is the most common human autoimmune disease.</p>
Autoren
DOI
10.1039/c8fo01570h
eISSN
2042-650X
ISSN
2042-6496
Ausgabe der Veröffentlichung
12
Zeitschrift
Food &amp; Function
Sprache
en
Online publication date
2018
Paginierung
6643 - 6651
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/c8fo01570h
Datum der Datenerfassung
2024
Titel
The prophylactic effect of a<i>Eugenia aquea</i>extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model
Ausgabe der Zeitschrift
9

Data source: Crossref

Abstract
Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Antioxidant and anti-inflammatory activities were investigated in rats with adjuvant-induced arthritis (AIA). An AIA rat model received orally/daily a vehicle, diclofenac (100 mg per kg b.w.), and E. aquea extract (50 or 100 or 200 mg per kg b.w.; for 21 days). Fifty-five out of 70 compounds (97.77%) were identified: eucalyptol (34.14%), α-pinene (15.91%), l-verbenone (8.01%), camphor (7.38%) and borneol (6.74%). In an acute oral toxicity study, the E. aquea extract did not show any toxic effects in rats at 2000 mg/ kg-1. Only a high dose of the E. aquea extract or diclofenac significantly alleviated (P < 0.05-0.001) all complications observed in arthritic rats, including body weight loss, articular/extra-articular oxidative injury and synovial joint inflammation by increasing food intake as well as improving the antioxidant defense system and inflammatory marker. The dose-dependent modulatory activity of the E. aquea extract was statistically significant. It was equivalent to and sometimes even better than that of diclofenac. The present study proved the antioxidant and anti-inflammatory activities of the E. aquea extract, which could be attributed to the presence of eucalyptol and α-pinene.
Addresses
  • Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt.
Autoren
DOI
10.1039/c8fo01570h
eISSN
2042-650X
Externe Identifier
  • PubMed Identifier: 30511707
Open access
false
ISSN
2042-6496
Ausgabe der Veröffentlichung
12
Zeitschrift
Food & function
Schlüsselwörter
  • Animals
  • Humans
  • Rats
  • Eugenia
  • Arthritis, Rheumatoid
  • Monoterpenes
  • Anti-Inflammatory Agents
  • Plant Extracts
  • Antioxidants
  • Oxidative Stress
  • Female
  • Eucalyptol
  • Bicyclic Monoterpenes
Sprache
eng
Medium
Print
Paginierung
6643 - 6651
Datum der Veröffentlichung
2018
Status
Published
Datum der Datenerfassung
2018
Titel
The prophylactic effect of a Eugenia aquea extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: Europe PubMed Central

Abstract
Rheumatoid arthritis (RA) is the most common human autoimmune disease. A petroleum ether extract of Eugenia aquea (E. aquea) was analyzed by GC/MS. Antioxidant and anti-inflammatory activities were investigated in rats with adjuvant-induced arthritis (AIA). An AIA rat model received orally/daily a vehicle, diclofenac (100 mg per kg b.w.), and E. aquea extract (50 or 100 or 200 mg per kg b.w.; for 21 days). Fifty-five out of 70 compounds (97.77%) were identified: eucalyptol (34.14%), α-pinene (15.91%), l-verbenone (8.01%), camphor (7.38%) and borneol (6.74%). In an acute oral toxicity study, the E. aquea extract did not show any toxic effects in rats at 2000 mg/ kg-1. Only a high dose of the E. aquea extract or diclofenac significantly alleviated (P < 0.05-0.001) all complications observed in arthritic rats, including body weight loss, articular/extra-articular oxidative injury and synovial joint inflammation by increasing food intake as well as improving the antioxidant defense system and inflammatory marker. The dose-dependent modulatory activity of the E. aquea extract was statistically significant. It was equivalent to and sometimes even better than that of diclofenac. The present study proved the antioxidant and anti-inflammatory activities of the E. aquea extract, which could be attributed to the presence of eucalyptol and α-pinene.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30511707
DOI
10.1039/c8fo01570h
eISSN
2042-650X
Ausgabe der Veröffentlichung
12
Zeitschrift
Food Funct
Schlüsselwörter
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Arthritis, Rheumatoid
  • Bicyclic Monoterpenes
  • Eucalyptol
  • Eugenia
  • Female
  • Humans
  • Monoterpenes
  • Oxidative Stress
  • Plant Extracts
  • Rats
Sprache
eng
Country
England
Paginierung
6643 - 6651
Datum der Veröffentlichung
2018
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
The prophylactic effect of a Eugenia aquea extract against oxidative stress and inflammation associated with the development of arthritis in an adjuvant-induced arthritis rat model.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
9

Data source: PubMed

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