Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii

Publication type:
Journal article
Metadata:
Autoren
  • Blaise Kemajou Nganou
  • Armelle T Mbaveng
  • Serge AT Fobofou
  • Aime G Fankam
  • Gabin Thierry M Bitchagno
  • James D Simo Mpetga
  • Ludger A Wessjohann
  • Victor Kuete
  • Thomas Efferth
  • Pierre Tane
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000461536300030&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.fitote.2019.01.003
eISSN
1873-6971
Externe Identifier
  • Clarivate Analytics Document Solution ID: HP2WO
  • PubMed Identifier: 30654126
ISSN
0367-326X
Zeitschrift
FITOTERAPIA
Schlüsselwörter
  • Araliopsis soyauxii
  • Rutaceae
  • Maculine B
  • Kokusaginine B
  • Veprisazole
  • Cytotoxicity
Paginierung
193 - 199
Datum der Veröffentlichung
2019
Status
Published
Titel
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of <i>Araliopsis soyauxii</i>
Sub types
  • Article
Ausgabe der Zeitschrift
133

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Blaise Kemajou Nganou
  • Armelle T Mbaveng
  • Serge AT Fobofou
  • Aimé G Fankam
  • Gabin Thierry M Bitchagno
  • James D Simo Mpetga
  • Ludger A Wessjohann
  • Victor Kuete
  • Thomas Efferth
  • Pierre Tane
DOI
10.1016/j.fitote.2019.01.003
ISSN
0367-326X
Zeitschrift
Fitoterapia
Sprache
en
Paginierung
193 - 199
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.fitote.2019.01.003
Datum der Datenerfassung
2019
Titel
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii
Ausgabe der Zeitschrift
133

Data source: Crossref

Abstract
Two new furoquinoline alkaloids, maculine B (1) and kokusaginine B (2) and one new dihydrooxazole alkaloid, veprisazole (3), along with four known compounds namely, N<sub>13</sub>-methyl-3-methoxyrutaecarpine (4), flindersiamine (5), skimmianine (6) and tilianin (7) were isolated from the methanol extract of the stem bark of Araliopsis soyauxii Engl. by various chromatographic methods. Their structures were determined using spectrometry and spectroscopic techniques including NMR and MS. The cytotoxicity of the new compounds compared to that of doxorubicin, the reference anticancer compound, was determined on a panel of nine cancer cell lines including sensitive and drug resistant phenotypes. The three previously undescribed alkaloids displayed selective activities. Maculine B (1), the most active one among the newly described compounds, exhibited IC<sub>50</sub> below 30 μM against CCRF-CEM leukemia and U87MG glioblastoma cells.
Addresses
  • Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Autoren
  • Blaise Kemajou Nganou
  • Armelle T Mbaveng
  • Serge AT Fobofou
  • Aimé G Fankam
  • Gabin Thierry M Bitchagno
  • James D Simo Mpetga
  • Ludger A Wessjohann
  • Victor Kuete
  • Thomas Efferth
  • Pierre Tane
DOI
10.1016/j.fitote.2019.01.003
eISSN
1873-6971
Externe Identifier
  • PubMed Identifier: 30654126
Funding acknowledgements
  • DAAD/BMBF: 57369155/100318210
  • Alexander von Humboldt Foundation:
Open access
false
ISSN
0367-326X
Zeitschrift
Fitoterapia
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Rutaceae
  • Plant Bark
  • Alkaloids
  • Dioxoles
  • Furans
  • Flavonoids
  • Quinolines
  • Glycosides
  • Antineoplastic Agents, Phytogenic
  • Drug Resistance, Multiple
  • Molecular Structure
  • Drug Resistance, Neoplasm
  • Cameroon
  • Phytochemicals
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
193 - 199
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
133

Data source: Europe PubMed Central

Abstract
Two new furoquinoline alkaloids, maculine B (1) and kokusaginine B (2) and one new dihydrooxazole alkaloid, veprisazole (3), along with four known compounds namely, N13-methyl-3-methoxyrutaecarpine (4), flindersiamine (5), skimmianine (6) and tilianin (7) were isolated from the methanol extract of the stem bark of Araliopsis soyauxii Engl. by various chromatographic methods. Their structures were determined using spectrometry and spectroscopic techniques including NMR and MS. The cytotoxicity of the new compounds compared to that of doxorubicin, the reference anticancer compound, was determined on a panel of nine cancer cell lines including sensitive and drug resistant phenotypes. The three previously undescribed alkaloids displayed selective activities. Maculine B (1), the most active one among the newly described compounds, exhibited IC50 below 30 μM against CCRF-CEM leukemia and U87MG glioblastoma cells.
Date of acceptance
2019
Autoren
  • Blaise Kemajou Nganou
  • Armelle T Mbaveng
  • Serge AT Fobofou
  • Aimé G Fankam
  • Gabin Thierry M Bitchagno
  • James D Simo Mpetga
  • Ludger A Wessjohann
  • Victor Kuete
  • Thomas Efferth
  • Pierre Tane
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30654126
DOI
10.1016/j.fitote.2019.01.003
eISSN
1873-6971
Zeitschrift
Fitoterapia
Schlüsselwörter
  • Araliopsis soyauxii
  • Cytotoxicity
  • Kokusaginine B
  • Maculine B
  • Rutaceae
  • Veprisazole
  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Cameroon
  • Cell Line, Tumor
  • Dioxoles
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Flavonoids
  • Furans
  • Glycosides
  • Humans
  • Molecular Structure
  • Phytochemicals
  • Plant Bark
  • Quinolines
  • Rutaceae
Sprache
eng
Country
Netherlands
Paginierung
193 - 199
PII
S0367-326X(18)31761-1
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
133

Data source: PubMed

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