Cardenolides: Insights from chemical structure and pharmacological utility

Publication type:
Journal article
Metadata:
Autoren
  • Hesham R El-Seedi
  • Shaden AM Khalifa
  • Eman A Taher
  • Mohamed A Farag
  • Aamer Saeed
  • Mohamed Gamal
  • Mohamed-Elamir F Hegazy
  • Diaa Youssef
  • Syed G Musharraf
  • Muaaz M Alajlani
  • Jianbo Xiao
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000460997000011&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phrs.2018.12.015
eISSN
1096-1186
Externe Identifier
  • Clarivate Analytics Document Solution ID: HO5VT
  • PubMed Identifier: 30579976
ISSN
1043-6618
Zeitschrift
PHARMACOLOGICAL RESEARCH
Schlüsselwörter
  • Cardiac glycosides
  • Chemical property space
  • Isolation
  • Heart failure
Paginierung
123 - 175
Datum der Veröffentlichung
2019
Status
Published
Titel
Cardenolides: Insights from chemical structure and pharmacological utility
Sub types
  • Review
Ausgabe der Zeitschrift
141

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Hesham R El-Seedi
  • Shaden AM Khalifa
  • Eman A Taher
  • Mohamed A Farag
  • Aamer Saeed
  • Mohamed Gamal
  • Mohamed-Elamir F Hegazy
  • Diaa Youssef
  • Syed G Musharraf
  • Muaaz M Alajlani
  • Jianbo Xiao
  • Thomas Efferth
DOI
10.1016/j.phrs.2018.12.015
ISSN
1043-6618
Zeitschrift
Pharmacological Research
Sprache
en
Paginierung
123 - 175
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phrs.2018.12.015
Datum der Datenerfassung
2022
Titel
Cardenolides: Insights from chemical structure and pharmacological utility
Ausgabe der Zeitschrift
141

Data source: Crossref

Abstract
Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na<sup>+</sup>/K<sup>+</sup>-ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer. In this review, we highlight some of the structural features of this class of natural products that are crucial for their efficacy, some methods of isolating these compounds from natural resources, and the structural elucidation tools that have been used. We also describe their physicochemical properties and several modern biotechnological approaches for preparing CGs that do not require plant sources.
Addresses
  • Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-75123, Uppsala, Sweden; Chemistry Department, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt. Electronic address: hesham.el-seedi@ilk.uu.se.
Autoren
  • Hesham R El-Seedi
  • Shaden AM Khalifa
  • Eman A Taher
  • Mohamed A Farag
  • Aamer Saeed
  • Mohamed Gamal
  • Mohamed-Elamir F Hegazy
  • Diaa Youssef
  • Syed G Musharraf
  • Muaaz M Alajlani
  • Jianbo Xiao
  • Thomas Efferth
DOI
10.1016/j.phrs.2018.12.015
eISSN
1096-1186
Externe Identifier
  • PubMed Identifier: 30579976
Funding acknowledgements
  • VR: 2016-05908
Open access
false
ISSN
1043-6618
Zeitschrift
Pharmacological research
Schlüsselwörter
  • Animals
  • Humans
  • Cardenolides
  • Cardiovascular Agents
  • Diuretics
  • Antineoplastic Agents
Sprache
eng
Medium
Print-Electronic
Online publication date
2018
Paginierung
123 - 175
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2018
Titel
Cardenolides: Insights from chemical structure and pharmacological utility.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
141

Data source: Europe PubMed Central

Abstract
Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+/K+-ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer. In this review, we highlight some of the structural features of this class of natural products that are crucial for their efficacy, some methods of isolating these compounds from natural resources, and the structural elucidation tools that have been used. We also describe their physicochemical properties and several modern biotechnological approaches for preparing CGs that do not require plant sources.
Date of acceptance
2018
Autoren
  • Hesham R El-Seedi
  • Shaden AM Khalifa
  • Eman A Taher
  • Mohamed A Farag
  • Aamer Saeed
  • Mohamed Gamal
  • Mohamed-Elamir F Hegazy
  • Diaa Youssef
  • Syed G Musharraf
  • Muaaz M Alajlani
  • Jianbo Xiao
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30579976
DOI
10.1016/j.phrs.2018.12.015
eISSN
1096-1186
Zeitschrift
Pharmacol Res
Schlüsselwörter
  • Cardiac glycosides
  • Chemical property space
  • Heart failure
  • Isolation
  • Animals
  • Antineoplastic Agents
  • Cardenolides
  • Cardiovascular Agents
  • Diuretics
  • Humans
Sprache
eng
Country
Netherlands
Paginierung
123 - 175
PII
S1043-6618(18)31185-X
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Cardenolides: Insights from chemical structure and pharmacological utility.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
141

Data source: PubMed

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