2′-O-galloylhyperin attenuates LPS-induced acute lung injury via upregulation antioxidation and inhibition of inflammatory responses in vivo

Publication type:
Journal article
Metadata:
Autoren
  • Sun-Dong Zhang
  • Peng Wang
  • Jing Zhang
  • Wei Wang
  • Li-Ping Yao
  • Cheng-Bo Gu
  • Thomas Efferth
  • Yu-Jie Fu
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000464937700003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.cbi.2019.02.029
eISSN
1872-7786
Externe Identifier
  • Clarivate Analytics Document Solution ID: HU0BZ
  • PubMed Identifier: 30849337
ISSN
0009-2797
Zeitschrift
CHEMICO-BIOLOGICAL INTERACTIONS
Schlüsselwörter
  • 2 '-O-galloylhyperin
  • Acute lung injury
  • Lipopolysaccharide
  • Inflammation response
  • Antioxidation
Paginierung
20 - 27
Datum der Veröffentlichung
2019
Status
Published
Titel
2′-<i>O</i>-galloylhyperin attenuates LPS-induced acute lung injury via upregulation antioxidation and inhibition of inflammatory responses <i>in vivo</i>
Sub types
  • Article
Ausgabe der Zeitschrift
304

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Sun-Dong Zhang
  • Peng Wang
  • Jing Zhang
  • Wei Wang
  • Li-Ping Yao
  • Cheng-Bo Gu
  • Thomas Efferth
  • Yu-Jie Fu
DOI
10.1016/j.cbi.2019.02.029
ISSN
0009-2797
Zeitschrift
Chemico-Biological Interactions
Sprache
en
Paginierung
20 - 27
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.cbi.2019.02.029
Datum der Datenerfassung
2019
Titel
2′O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo
Ausgabe der Zeitschrift
304

Data source: Crossref

Abstract
2'O-galloylhyperin, an active flavonol glycoside compound with remarkable anti-immune activity, was isolated from Pyrola [P. incarnata Fisch.]. However, the evidence of anti-inflammatory activity in pulmonary diseases was still not convincing. The aim of the present study was (1) to investigate the effect of 2'O-galloylhyperin on LPS-induced acute lung injury in mice, and (2) to identify the mechanisms of attenuation of inflammatory responses. The results demonstrated that 2'O-galloylhyperin significantly reduced LPS-induced inflammation damage in a dose-dependent manner. After LPS challenge, treatment with 2'O-galloylhyperin reduced the production of pro-inflammatory cytokines and chemokines, and also improved LPS-induced lung histopathology changes. 2'O-galloylhyperin also increased the activities of antioxidant enzymes, including SOD and GSH-Px to maintain cellular redox homeostasis. Furthermore, 2'O-galloylhyperin inhibited translocation of nuclear factor (NF-κB) activation and suppressed phosphorylation of MAPK signaling pathway consisting of p38, ERK, JNK. In addition, 2'O-galloylhyperin enhanced heme oxygenase-1 (HO-1) expression to block LPS-induced inflammation via activating nuclear factor-crythroid 2-related factor (Nrf2). Moreover, 2'O-galloylhyperin induced adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation. 2'O-galloylhyperin attenuated LPS-induced acute lung injury by inhibiting the MAPK and NF-κB signaling pathways, presumably related to up-regulation of the AMPK and Nrf2 signaling pathways. Furthermore, 2'O-galloylhyperin is a potential protective antioxidant to protect lung tissues from the acute injury.
Addresses
  • Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, China.
Autoren
  • Sun-Dong Zhang
  • Peng Wang
  • Jing Zhang
  • Wei Wang
  • Li-Ping Yao
  • Cheng-Bo Gu
  • Thomas Efferth
  • Yu-Jie Fu
DOI
10.1016/j.cbi.2019.02.029
eISSN
1872-7786
Externe Identifier
  • PubMed Identifier: 30849337
Funding acknowledgements
  • Central Universities: 2572017ET03
  • Central Universities: 2572017AA10
  • National Key R&amp;D Program of China: 2016YFD0600805
  • Central Universities: 2572017EA03
Open access
false
ISSN
0009-2797
Zeitschrift
Chemico-biological interactions
Schlüsselwörter
  • Animals
  • Mice, Inbred ICR
  • Mice
  • Inflammation
  • Gallic Acid
  • Quercetin
  • Lipopolysaccharides
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Up-Regulation
  • Molecular Conformation
  • Structure-Activity Relationship
  • Dose-Response Relationship, Drug
  • Male
  • Acute Lung Injury
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
20 - 27
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
2'O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
304

Data source: Europe PubMed Central

Abstract
2'O-galloylhyperin, an active flavonol glycoside compound with remarkable anti-immune activity, was isolated from Pyrola [P. incarnata Fisch.]. However, the evidence of anti-inflammatory activity in pulmonary diseases was still not convincing. The aim of the present study was (1) to investigate the effect of 2'O-galloylhyperin on LPS-induced acute lung injury in mice, and (2) to identify the mechanisms of attenuation of inflammatory responses. The results demonstrated that 2'O-galloylhyperin significantly reduced LPS-induced inflammation damage in a dose-dependent manner. After LPS challenge, treatment with 2'O-galloylhyperin reduced the production of pro-inflammatory cytokines and chemokines, and also improved LPS-induced lung histopathology changes. 2'O-galloylhyperin also increased the activities of antioxidant enzymes, including SOD and GSH-Px to maintain cellular redox homeostasis. Furthermore, 2'O-galloylhyperin inhibited translocation of nuclear factor (NF-κB) activation and suppressed phosphorylation of MAPK signaling pathway consisting of p38, ERK, JNK. In addition, 2'O-galloylhyperin enhanced heme oxygenase-1 (HO-1) expression to block LPS-induced inflammation via activating nuclear factor-crythroid 2-related factor (Nrf2). Moreover, 2'O-galloylhyperin induced adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation. 2'O-galloylhyperin attenuated LPS-induced acute lung injury by inhibiting the MAPK and NF-κB signaling pathways, presumably related to up-regulation of the AMPK and Nrf2 signaling pathways. Furthermore, 2'O-galloylhyperin is a potential protective antioxidant to protect lung tissues from the acute injury.
Date of acceptance
2019
Autoren
  • Sun-Dong Zhang
  • Peng Wang
  • Jing Zhang
  • Wei Wang
  • Li-Ping Yao
  • Cheng-Bo Gu
  • Thomas Efferth
  • Yu-Jie Fu
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/30849337
DOI
10.1016/j.cbi.2019.02.029
eISSN
1872-7786
Zeitschrift
Chem Biol Interact
Schlüsselwörter
  • 2′O-galloylhyperin
  • Acute lung injury
  • Antioxidation
  • Inflammation response
  • Lipopolysaccharide
  • Acute Lung Injury
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Dose-Response Relationship, Drug
  • Gallic Acid
  • Inflammation
  • Lipopolysaccharides
  • Male
  • Mice
  • Mice, Inbred ICR
  • Molecular Conformation
  • Quercetin
  • Structure-Activity Relationship
  • Up-Regulation
Sprache
eng
Country
Ireland
Paginierung
20 - 27
PII
S0009-2797(18)31036-6
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
2'O-galloylhyperin attenuates LPS-induced acute lung injury via up-regulation antioxidation and inhibition of inflammatory responses in vivo.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
304

Data source: PubMed

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