Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Ge Yan
- Mohamed EM Saeed
- Sebastian Foersch
- Jose Schneider
- Wilfried Roth
- Thomas Efferth
- DOI
- 10.18632/oncotarget.26727
- eISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 20
- Zeitschrift
- Oncotarget
- Sprache
- en
- Online publication date
- 2019
- Paginierung
- 1918 - 1931
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Impact Journals, LLC
- Herausgeber URL
- http://dx.doi.org/10.18632/oncotarget.26727
- Datum der Datenerfassung
- 2020
- Titel
- Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Other metadata sources:
-
- Abstract
- Epidermal growth factor receptor (EGFR) as a prevalent oncogene regulates proliferation, apoptosis and differentiation and thereby contributes to carcinogenesis. Even though, the documentation on its clinical relevance is surprisingly heterogeneous in the scientific literature. Here, we systematically investigated the correlation of mRNA to survival time and pathological parameters by analyzing 30 datasets <i>in silico</i>. Furthermore, the prognostic value of membrane-bound, cytoplasmic (mcEGFR) and nuclear expression (nEGFR) of EGFR was experimentally analyzed by immunohistochemical staining of 502 biopsies from 27 tumor types. We found that protein expression of EGFR showed better prognostic efficiency compared to mRNA, and that mcEGFR expression was positively correlated with nEGFR expression (<i>p</i> < 0.001). Unexpectedly, both mcEGFR and nEGFR expression were associated with low T stage (<i>p</i> < 0.001 and <i>p</i> = 0.004; respectively). Moreover, positive mcEGFR was significantly related to high differentiation (<i>p</i> = 0.027). No significant correlation was found with any other pathological parameters. Collectively, our results imply that the oncogenic function of EGFR may be more related to nascent stages of carcinogenesis than to advanced and progressive tumors, which may as well explain at least partially the occurrence of secondary resistance against EGFR-directed therapy.
- Addresses
- Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.
- Autoren
- Ge Yan
- Mohamed EM Saeed
- Sebastian Foersch
- Jose Schneider
- Wilfried Roth
- Thomas Efferth
- DOI
- 10.18632/oncotarget.26727
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Identifier: 30956774
- PubMed Central ID: PMC6443015
- Open access
- true
- ISSN
- 1949-2553
- Ausgabe der Veröffentlichung
- 20
- Zeitschrift
- Oncotarget
- Sprache
- eng
- Medium
- Electronic-eCollection
- Online publication date
- 2019
- Open access status
- Open Access
- Paginierung
- 1918 - 1931
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2019
- Titel
- Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.oncotarget.com/article/26727/pdf/ https://europepmc.org/articles/PMC6443015?pdf=render
Data source: Europe PubMed Central
- Abstract
- Epidermal growth factor receptor (EGFR) as a prevalent oncogene regulates proliferation, apoptosis and differentiation and thereby contributes to carcinogenesis. Even though, the documentation on its clinical relevance is surprisingly heterogeneous in the scientific literature. Here, we systematically investigated the correlation of mRNA to survival time and pathological parameters by analyzing 30 datasets in silico. Furthermore, the prognostic value of membrane-bound, cytoplasmic (mcEGFR) and nuclear expression (nEGFR) of EGFR was experimentally analyzed by immunohistochemical staining of 502 biopsies from 27 tumor types. We found that protein expression of EGFR showed better prognostic efficiency compared to mRNA, and that mcEGFR expression was positively correlated with nEGFR expression (p < 0.001). Unexpectedly, both mcEGFR and nEGFR expression were associated with low T stage (p < 0.001 and p = 0.004; respectively). Moreover, positive mcEGFR was significantly related to high differentiation (p = 0.027). No significant correlation was found with any other pathological parameters. Collectively, our results imply that the oncogenic function of EGFR may be more related to nascent stages of carcinogenesis than to advanced and progressive tumors, which may as well explain at least partially the occurrence of secondary resistance against EGFR-directed therapy.
- Date of acceptance
- 2019
- Autoren
- Ge Yan
- Mohamed EM Saeed
- Sebastian Foersch
- Jose Schneider
- Wilfried Roth
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/30956774
- DOI
- 10.18632/oncotarget.26727
- eISSN
- 1949-2553
- Externe Identifier
- PubMed Central ID: PMC6443015
- Ausgabe der Veröffentlichung
- 20
- Zeitschrift
- Oncotarget
- Schlüsselwörter
- biomarker
- oncogene
- pathological parameters
- prognosis
- survival
- Sprache
- eng
- Country
- United States
- Paginierung
- 1918 - 1931
- PII
- 26727
- Datum der Veröffentlichung
- 2019
- Status
- Published online
- Titel
- Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
- Beziehungen:
- Property of