MicroRNA targeting by quercetin in cancer treatment and chemoprotection
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Doo Hwan Kim
- Haroon Khan
- Hammad Ullah
- Sherif TS Hassan
- Karel Smejkal
- Thomas Efferth
- Mohamad Fawzi Mahomoodally
- Suowen Xu
- Solomon Habtemariarn
- Rosanna Filosa
- Ricardo Lagoa
- Kannan RR Rengasamy
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000487565500006&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phrs.2019.104346
- eISSN
- 1096-1186
- Externe Identifier
- Clarivate Analytics Document Solution ID: JA1GM
- PubMed Identifier: 31295570
- ISSN
- 1043-6618
- Zeitschrift
- PHARMACOLOGICAL RESEARCH
- Schlüsselwörter
- Cancer
- Chemoprevention
- Epigenetic regulation
- Flavonoids
- Carcinogenesis
- Bioinformatic tools
- Artikelnummer
- ARTN 104346
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Titel
- MicroRNA targeting by quercetin in cancer treatment and chemoprotection
- Sub types
- Article
- Ausgabe der Zeitschrift
- 147
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Doo Hwan Kim
- Haroon Khan
- Hammad Ullah
- Sherif TS Hassan
- Karel Šmejkal
- Thomas Efferth
- Mohamad Fawzi Mahomoodally
- Suowen Xu
- Solomon Habtemariam
- Rosanna Filosa
- Ricardo Lagoa
- Kannan RR Rengasamy
- DOI
- 10.1016/j.phrs.2019.104346
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological Research
- Sprache
- en
- Artikelnummer
- 104346
- Paginierung
- 104346 - 104346
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phrs.2019.104346
- Datum der Datenerfassung
- 2019
- Titel
- MicroRNA targeting by quercetin in cancer treatment and chemoprotection
- Ausgabe der Zeitschrift
- 147
Data source: Crossref
- Abstract
- A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health-promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.
- Addresses
- Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea.
- Autoren
- Doo Hwan Kim
- Haroon Khan
- Hammad Ullah
- Hammad Ullah
- Sherif TS Hassan
- Karel Šmejkal
- Thomas Efferth
- Mohamad Fawzi Mahomoodally
- Suowen Xu
- Solomon Habtemariam
- Rosanna Filosa
- Ricardo Lagoa
- Kannan Rr Rengasamy
- DOI
- 10.1016/j.phrs.2019.104346
- eISSN
- 1096-1186
- Externe Identifier
- PubMed Identifier: 31295570
- Funding acknowledgements
- Konkuk University:
- Open access
- false
- ISSN
- 1043-6618
- Zeitschrift
- Pharmacological research
- Schlüsselwörter
- Animals
- Humans
- Neoplasms
- Quercetin
- MicroRNAs
- Antineoplastic Agents
- Antioxidants
- Chemoprevention
- Drug Discovery
- Biomarkers
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2019
- Paginierung
- 104346
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum der Datenerfassung
- 2019
- Titel
- MicroRNA targeting by quercetin in cancer treatment and chemoprotection.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 147
Data source: Europe PubMed Central
- Abstract
- A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health-promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.
- Date of acceptance
- 2019
- Autoren
- Doo Hwan Kim
- Haroon Khan
- Hammad Ullah
- Sherif TS Hassan
- Karel Šmejkal
- Thomas Efferth
- Mohamad Fawzi Mahomoodally
- Suowen Xu
- Solomon Habtemariam
- Rosanna Filosa
- Ricardo Lagoa
- Kannan Rr Rengasamy
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/31295570
- DOI
- 10.1016/j.phrs.2019.104346
- eISSN
- 1096-1186
- Zeitschrift
- Pharmacol Res
- Schlüsselwörter
- Bioinformatic tools
- Cancer
- Carcinogenesis
- Chemoprevention
- Epigenetic regulation
- Flavonoids
- Animals
- Antineoplastic Agents
- Antioxidants
- Biomarkers
- Chemoprevention
- Drug Discovery
- Humans
- MicroRNAs
- Neoplasms
- Quercetin
- Sprache
- eng
- Country
- Netherlands
- Paginierung
- 104346
- PII
- S1043-6618(19)30760-1
- Datum der Veröffentlichung
- 2019
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2020
- Titel
- MicroRNA targeting by quercetin in cancer treatment and chemoprotection.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 147
Data source: PubMed
- Beziehungen:
- Property of