Interactions between artemisinin derivatives and P-glycoprotein

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000485781500018&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2019.152998
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: IX6GQ
  • PubMed Identifier: 31301971
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Artemisinin
  • Cancer
  • Chemotherapy
  • Multidrug resistance
  • Natural products
  • P-glycoprotein
Artikelnummer
ARTN 152998
Datum der Veröffentlichung
2019
Status
Published
Titel
Interactions between artemisinin derivatives and P-glycoprotein
Sub types
  • Article
Ausgabe der Zeitschrift
60

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2019.152998
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
152998
Paginierung
152998 - 152998
Datum der Veröffentlichung
2019
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2019.152998
Datum der Datenerfassung
2023
Titel
Interactions between artemisinin derivatives and P-glycoprotein
Ausgabe der Zeitschrift
60

Data source: Crossref

Abstract
<h4>Background</h4>Artemisinin was isolated and identified in 1972, which was the starting point for a new era in antimalarial drug therapy. Furthermore, numerous studies have demonstrated that artemisinin and its derivatives exhibit considerable anticancer activity both in vitro, in vivo, and even in clinical Phase I/II trials. P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) is one of the most serious causes of chemotherapy failure in cancer treatment. Interestingly, many artemisinin derivatives exhibit excellent ability to overcome P-gp mediated MDR and even show collateral sensitivity against MDR cancer cells. Furthermore, some artemisinin derivatives show P-gp-mediated MDR reversal activity. Therefore, the interaction between P-gp and artemisinin derivatives is important to develop novel combination treatment protocols with artemisinin derivatives and established anticancer drugs that are P-gp substrates.<h4>Purpose</h4>This systematic review provides an updated overview on the interaction between artemisinin derivatives and P-gp and the effect of artemisinin derivatives on the P-gp expression level.<h4>Results</h4>Artemisinin derivatives exhibit multi-specific interactions with P-gp. The currently used artemisinin derivatives are not transported by P-gp. However, some of novel synthetized artemisinin derivatives exhibit P-gp substrate properties. Furthermore, many artemisinin derivatives act as P-gp inhibitors, which exhibit the potential to reverse MDR towards clinically used anticancer drugs.<h4>Conclusion</h4>Therefore, studies on the interaction between artemisinin derivatives and P-gp provide important information for the development of novel anti-cancer artemisinin derivatives to reverse P-gp mediated MDR and for the design of rational artemisinin-based combination therapies against cancer.
Addresses
  • College of Pharmacy, Dalian Medical University, Dalian 116044, China.
Autoren
DOI
10.1016/j.phymed.2019.152998
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 31301971
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Neoplasms
  • Artemisinins
  • Antineoplastic Agents
  • Drug Resistance, Multiple
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
152998
Datum der Veröffentlichung
2019
Status
Published
Datum der Datenerfassung
2019
Titel
Interactions between artemisinin derivatives and P-glycoprotein.
Sub types
  • Systematic Review
  • Journal Article
Ausgabe der Zeitschrift
60

Data source: Europe PubMed Central

Abstract
BACKGROUND: Artemisinin was isolated and identified in 1972, which was the starting point for a new era in antimalarial drug therapy. Furthermore, numerous studies have demonstrated that artemisinin and its derivatives exhibit considerable anticancer activity both in vitro, in vivo, and even in clinical Phase I/II trials. P-glycoprotein (P-gp) mediated multi-drug resistance (MDR) is one of the most serious causes of chemotherapy failure in cancer treatment. Interestingly, many artemisinin derivatives exhibit excellent ability to overcome P-gp mediated MDR and even show collateral sensitivity against MDR cancer cells. Furthermore, some artemisinin derivatives show P-gp-mediated MDR reversal activity. Therefore, the interaction between P-gp and artemisinin derivatives is important to develop novel combination treatment protocols with artemisinin derivatives and established anticancer drugs that are P-gp substrates. PURPOSE: This systematic review provides an updated overview on the interaction between artemisinin derivatives and P-gp and the effect of artemisinin derivatives on the P-gp expression level. RESULTS: Artemisinin derivatives exhibit multi-specific interactions with P-gp. The currently used artemisinin derivatives are not transported by P-gp. However, some of novel synthetized artemisinin derivatives exhibit P-gp substrate properties. Furthermore, many artemisinin derivatives act as P-gp inhibitors, which exhibit the potential to reverse MDR towards clinically used anticancer drugs. CONCLUSION: Therefore, studies on the interaction between artemisinin derivatives and P-gp provide important information for the development of novel anti-cancer artemisinin derivatives to reverse P-gp mediated MDR and for the design of rational artemisinin-based combination therapies against cancer.
Date of acceptance
2019
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31301971
DOI
10.1016/j.phymed.2019.152998
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Artemisinin
  • Cancer
  • Chemotherapy
  • Multidrug resistance
  • Natural products
  • P-glycoprotein
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Artemisinins
  • Drug Resistance, Multiple
  • Humans
  • Neoplasms
Sprache
eng
Country
Germany
Paginierung
152998
PII
S0944-7113(19)30165-5
Datum der Veröffentlichung
2019
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2019
Titel
Interactions between artemisinin derivatives and P-glycoprotein.
Sub types
  • Journal Article
  • Systematic Review
Ausgabe der Zeitschrift
60

Data source: PubMed

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