Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000616365300014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.semcancer.2019.12.010
eISSN
1096-3650
Externe Identifier
  • Clarivate Analytics Document Solution ID: QE7DP
  • PubMed Identifier: 31883912
ISSN
1044-579X
Zeitschrift
SEMINARS IN CANCER BIOLOGY
Schlüsselwörter
  • Natural products
  • Phytochemicals
  • Network pharmacology
  • Targeted chemotherapy
Paginierung
143 - 163
Datum der Veröffentlichung
2021
Status
Published
Titel
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology
Sub types
  • Review
Ausgabe der Zeitschrift
68

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.semcancer.2019.12.010
ISSN
1044-579X
Zeitschrift
Seminars in Cancer Biology
Sprache
en
Paginierung
143 - 163
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.semcancer.2019.12.010
Datum der Datenerfassung
2021
Titel
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology
Ausgabe der Zeitschrift
68

Data source: Crossref

Abstract
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new treatment indications. Phytochemicals isolated from medicinal plants have been largely neglected in this context, although their pharmacological activities have been well investigated in the past, and they may have considerable potentials for repositioning. A grand number of plant alkaloids inhibit syngeneic or xenograft tumor growth in vivo. Molecular modes of action in cancer cells include induction of cell cycle arrest, intrinsic and extrinsic apoptosis, autophagy, inhibition of angiogenesis and glycolysis, stress and anti-inflammatory responses, regulation of immune functions, cellular differentiation, and inhibition of invasion and metastasis. Numerous underlying signaling processes are affected by plant alkaloids. Furthermore, plant alkaloids suppress carcinogenesis, indicating chemopreventive properties. Some plant alkaloids reveal toxicities such as hepato-, nephro- or genotoxicity, which disqualifies them for repositioning purposes. Others even protect from hepatotoxicity or cardiotoxicity of xenobiotics and established anticancer drugs. The present survey of the published literature clearly demonstrates that plant alkaloids have the potential for repositioning in cancer therapy. Exploitation of the chemical diversity of natural alkaloids may enrich the candidate pool of compounds for cancer chemotherapy and -prevention. Their further preclinical and clinical development should follow the same stringent rules as for any other synthetic drug as well. Prospective randomized, placebo-controlled clinical phase I and II trials should be initiated to unravel the full potential of plant alkaloids for drug repositioning.
Addresses
  • Department of Pharmaceutical Biology, Johannes Gutenberg University, Mainz, Germany. Electronic address: efferth@uni-mainz.de.
Autoren
DOI
10.1016/j.semcancer.2019.12.010
eISSN
1096-3650
Externe Identifier
  • PubMed Identifier: 31883912
Open access
false
ISSN
1044-579X
Zeitschrift
Seminars in cancer biology
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Alkaloids
  • Antineoplastic Agents
  • Toxicity Tests
  • Drug Discovery
  • Drug Repositioning
  • Phytochemicals
Sprache
eng
Medium
Print-Electronic
Online publication date
2019
Paginierung
143 - 163
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2019
Titel
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
68

Data source: Europe PubMed Central

Abstract
Drug repurposing (or repositioning) is an emerging concept to use old drugs for new treatment indications. Phytochemicals isolated from medicinal plants have been largely neglected in this context, although their pharmacological activities have been well investigated in the past, and they may have considerable potentials for repositioning. A grand number of plant alkaloids inhibit syngeneic or xenograft tumor growth in vivo. Molecular modes of action in cancer cells include induction of cell cycle arrest, intrinsic and extrinsic apoptosis, autophagy, inhibition of angiogenesis and glycolysis, stress and anti-inflammatory responses, regulation of immune functions, cellular differentiation, and inhibition of invasion and metastasis. Numerous underlying signaling processes are affected by plant alkaloids. Furthermore, plant alkaloids suppress carcinogenesis, indicating chemopreventive properties. Some plant alkaloids reveal toxicities such as hepato-, nephro- or genotoxicity, which disqualifies them for repositioning purposes. Others even protect from hepatotoxicity or cardiotoxicity of xenobiotics and established anticancer drugs. The present survey of the published literature clearly demonstrates that plant alkaloids have the potential for repositioning in cancer therapy. Exploitation of the chemical diversity of natural alkaloids may enrich the candidate pool of compounds for cancer chemotherapy and -prevention. Their further preclinical and clinical development should follow the same stringent rules as for any other synthetic drug as well. Prospective randomized, placebo-controlled clinical phase I and II trials should be initiated to unravel the full potential of plant alkaloids for drug repositioning.
Date of acceptance
2019
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31883912
DOI
10.1016/j.semcancer.2019.12.010
eISSN
1096-3650
Zeitschrift
Semin Cancer Biol
Schlüsselwörter
  • Natural products
  • Network pharmacology
  • Phytochemicals
  • Targeted chemotherapy
  • Alkaloids
  • Animals
  • Antineoplastic Agents
  • Drug Discovery
  • Drug Repositioning
  • Humans
  • Neoplasms
  • Phytochemicals
  • Toxicity Tests
Sprache
eng
Country
England
Paginierung
143 - 163
PII
S1044-579X(19)30408-0
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
68

Data source: PubMed

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