Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics)

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000536961500006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.bcp.2020.113792
eISSN
1873-2968
Externe Identifier
  • Clarivate Analytics Document Solution ID: LT3HJ
  • PubMed Identifier: 31926145
ISSN
0006-2952
Zeitschrift
BIOCHEMICAL PHARMACOLOGY
Schlüsselwörter
  • Natural product
  • iNOS
  • iNOS inhibitor
  • iNOS stimulator
  • Cancer
Artikelnummer
ARTN 113792
Datum der Veröffentlichung
2020
Status
Published
Titel
Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics)
Sub types
  • Review
Ausgabe der Zeitschrift
176

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.bcp.2020.113792
ISSN
0006-2952
Zeitschrift
Biochemical Pharmacology
Sprache
en
Artikelnummer
113792
Paginierung
113792 - 113792
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.bcp.2020.113792
Datum der Datenerfassung
2023
Titel
Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics)
Ausgabe der Zeitschrift
176

Data source: Crossref

Abstract
Nitric oxide synthases (NOS) are a family of isoforms, which generate nitric oxide (NO). NO is one of the smallest molecules in nature and acts mainly as a potent vasodilator. It participates in various biological processes ranging from physiological to pathological conditions. Inducible NOS (iNOS, NOS2) is a calcium-independent and inducible isoform. Despite high iNOS expression in many tumors, the role of iNOS is still unclear and complex with both enhancing and prohibiting actions in tumorigenesis. Nature presents a broad variety of natural stimulators and inhibitors, which may either promote or inhibit iNOS response. In the present review, we give an overview of iNOS-modulating agents with a special focus on both natural and synthetic molecules and their effects in related biological processes. The role of iNOS in physiological and pathological conditions is also discussed.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey.
Autoren
DOI
10.1016/j.bcp.2020.113792
eISSN
1873-2968
Externe Identifier
  • PubMed Identifier: 31926145
Open access
false
ISSN
0006-2952
Zeitschrift
Biochemical pharmacology
Schlüsselwörter
  • Animals
  • Humans
  • Neoplasms
  • Biological Products
  • Enzyme Inhibitors
  • Anti-Bacterial Agents
  • Enzyme Activation
  • Molecular Structure
  • Nitric Oxide Synthase Type II
  • Phytochemicals
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Paginierung
113792
Datum der Veröffentlichung
2020
Status
Published
Datum der Datenerfassung
2020
Titel
Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics).
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
176

Data source: Europe PubMed Central

Abstract
Nitric oxide synthases (NOS) are a family of isoforms, which generate nitric oxide (NO). NO is one of the smallest molecules in nature and acts mainly as a potent vasodilator. It participates in various biological processes ranging from physiological to pathological conditions. Inducible NOS (iNOS, NOS2) is a calcium-independent and inducible isoform. Despite high iNOS expression in many tumors, the role of iNOS is still unclear and complex with both enhancing and prohibiting actions in tumorigenesis. Nature presents a broad variety of natural stimulators and inhibitors, which may either promote or inhibit iNOS response. In the present review, we give an overview of iNOS-modulating agents with a special focus on both natural and synthetic molecules and their effects in related biological processes. The role of iNOS in physiological and pathological conditions is also discussed.
Date of acceptance
2020
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/31926145
DOI
10.1016/j.bcp.2020.113792
eISSN
1873-2968
Zeitschrift
Biochem Pharmacol
Schlüsselwörter
  • Cancer
  • Natural product
  • iNOS
  • iNOS inhibitor
  • iNOS stimulator
  • Animals
  • Anti-Bacterial Agents
  • Biological Products
  • Enzyme Activation
  • Enzyme Inhibitors
  • Humans
  • Molecular Structure
  • Neoplasms
  • Nitric Oxide Synthase Type II
  • Phytochemicals
Sprache
eng
Country
England
Paginierung
113792
PII
S0006-2952(20)30002-2
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics).
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
176

Data source: PubMed

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