Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

Publication type:
Journal article
Metadata:
Autoren
  • Xue-Lian Zhao
  • Liang Yu
  • Sun-Dong Zhang
  • Kou Ping
  • Hai-Yan Ni
  • Xiang-Yu Qin
  • Chun-Jian Zhao
  • Wei Wang
  • Thomas Efferth
  • Yu-Jie Fu
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000535959000026&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.intimp.2020.106436
eISSN
1878-1705
Externe Identifier
  • Clarivate Analytics Document Solution ID: LR8PQ
  • PubMed Identifier: 32234671
ISSN
1567-5769
Zeitschrift
INTERNATIONAL IMMUNOPHARMACOLOGY
Schlüsselwörter
  • Cryptochlorogenic acid
  • Anti-inflammatory
  • Antioxidant
  • NF-kappa B
  • MAPK
  • Nrf2
Artikelnummer
ARTN 106436
Datum der Veröffentlichung
2020
Status
Published
Titel
Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress <i>via</i> upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages
Sub types
  • Article
Ausgabe der Zeitschrift
83

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Xue-Lian Zhao
  • Liang Yu
  • Sun-Dong Zhang
  • Kou Ping
  • Hai-Yan Ni
  • Xiang-Yu Qin
  • Chun-Jian Zhao
  • Wei Wang
  • Thomas Efferth
  • Yu-Jie Fu
DOI
10.1016/j.intimp.2020.106436
ISSN
1567-5769
Zeitschrift
International Immunopharmacology
Sprache
en
Artikelnummer
106436
Paginierung
106436 - 106436
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.intimp.2020.106436
Datum der Datenerfassung
2023
Titel
Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages
Ausgabe der Zeitschrift
83

Data source: Crossref

Abstract
Phenolic acids are found in natural plants, such as caffeic acid, rosmarinic acid, and chlorogenic acid. They have long been used as pharmacological actives, owing to their anti-inflammatory and antioxidant activities. Cryptochlorogenic acid (CCGA) is a special isomer of chlorogenic acid; the pharmacological effects and related molecular mechanisms of CCGA have been poorly reported. In the present study, the antioxidant and anti-inflammatory effects of CCGA in RAW 264.7 macrophages and the underlying mechanisms were investigated. The results revealed that CCGA dose-dependently inhibited LPS-induced production of NO, TNF-α, and IL-6 and blocked iNOS, COX-2, TNF-α, and IL-6 expressions. CCGA also significantly increased the GSH/GSSG ratio and SOD activity and reduced the MDA level. Moreover, CCGA suppressed the nuclear translocation of NF-κB by hindering the phosphorylation of IκB kinase (IKK) and degrading IκB. It also downregulated the phosphorylation of MAPKs. Our results indicated that CCGA significantly inhibited NF-κB activation by controlling the expression of pro-inflammatory factors and promoting the nuclear transfer of Nrf2. In conclusion, CCGA could attenuate LPS-induced inflammatory symptoms by modulating NF-κB/MAPK signaling cascades and inhibit LPS-induced oxidative stress via Nrf2 nuclear translocation.
Addresses
  • College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin 150040, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
Autoren
  • Xue-Lian Zhao
  • Liang Yu
  • Sun-Dong Zhang
  • Kou Ping
  • Hai-Yan Ni
  • Xiang-Yu Qin
  • Chun-Jian Zhao
  • Wei Wang
  • Thomas Efferth
  • Yu-Jie Fu
DOI
10.1016/j.intimp.2020.106436
eISSN
1878-1705
Externe Identifier
  • PubMed Identifier: 32234671
Funding acknowledgements
  • Fundamental Research Funds for the Central Universities:
Open access
false
ISSN
1567-5769
Zeitschrift
International immunopharmacology
Schlüsselwörter
  • Macrophages
  • Animals
  • Mice
  • Inflammation
  • Chlorogenic Acid
  • Lipopolysaccharides
  • NF-kappa B
  • Membrane Proteins
  • Anti-Inflammatory Agents
  • Inflammation Mediators
  • Antioxidants
  • Signal Transduction
  • MAP Kinase Signaling System
  • Oxidative Stress
  • NF-E2-Related Factor 2
  • Heme Oxygenase-1
  • I-kappa B Kinase
  • RAW 264.7 Cells
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Paginierung
106436
Datum der Veröffentlichung
2020
Status
Published
Datum der Datenerfassung
2020
Titel
Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
83

Data source: Europe PubMed Central

Abstract
Phenolic acids are found in natural plants, such as caffeic acid, rosmarinic acid, and chlorogenic acid. They have long been used as pharmacological actives, owing to their anti-inflammatory and antioxidant activities. Cryptochlorogenic acid (CCGA) is a special isomer of chlorogenic acid; the pharmacological effects and related molecular mechanisms of CCGA have been poorly reported. In the present study, the antioxidant and anti-inflammatory effects of CCGA in RAW 264.7 macrophages and the underlying mechanisms were investigated. The results revealed that CCGA dose-dependently inhibited LPS-induced production of NO, TNF-α, and IL-6 and blocked iNOS, COX-2, TNF-α, and IL-6 expressions. CCGA also significantly increased the GSH/GSSG ratio and SOD activity and reduced the MDA level. Moreover, CCGA suppressed the nuclear translocation of NF-κB by hindering the phosphorylation of IκB kinase (IKK) and degrading IκB. It also downregulated the phosphorylation of MAPKs. Our results indicated that CCGA significantly inhibited NF-κB activation by controlling the expression of pro-inflammatory factors and promoting the nuclear transfer of Nrf2. In conclusion, CCGA could attenuate LPS-induced inflammatory symptoms by modulating NF-κB/MAPK signaling cascades and inhibit LPS-induced oxidative stress via Nrf2 nuclear translocation.
Date of acceptance
2020
Autoren
  • Xue-Lian Zhao
  • Liang Yu
  • Sun-Dong Zhang
  • Kou Ping
  • Hai-Yan Ni
  • Xiang-Yu Qin
  • Chun-Jian Zhao
  • Wei Wang
  • Thomas Efferth
  • Yu-Jie Fu
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32234671
DOI
10.1016/j.intimp.2020.106436
eISSN
1878-1705
Zeitschrift
Int Immunopharmacol
Schlüsselwörter
  • Anti-inflammatory
  • Antioxidant
  • Cryptochlorogenic acid
  • MAPK
  • NF-κB
  • Nrf2
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Chlorogenic Acid
  • Heme Oxygenase-1
  • I-kappa B Kinase
  • Inflammation
  • Inflammation Mediators
  • Lipopolysaccharides
  • MAP Kinase Signaling System
  • Macrophages
  • Membrane Proteins
  • Mice
  • NF-E2-Related Factor 2
  • NF-kappa B
  • Oxidative Stress
  • RAW 264.7 Cells
  • Signal Transduction
Sprache
eng
Country
Netherlands
Paginierung
106436
PII
S1567-5769(19)32903-0
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
83

Data source: PubMed

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