Targeting epigenetics in cancer: therapeutic potential of flavonoids
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Haroon Khan
- Tarun Belwal
- Thomas Efferth
- Ammad Ahmad Farooqi
- Ana Sanches-Silva
- Rosa Anna Vacca
- Seyed Fazel Nabavi
- Fazlullah Khan
- Hari Prasad Devkota
- Davide Barreca
- Antoni Sureda
- Silvia Tejada
- Marco Dacrema
- Maria Daglia
- Ipek Suntar
- Suowen Xu
- Hammad Ullah
- Maurizio Battino
- Francesca Giampieri
- Seyed Mohammad Nabavi
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000542009300001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1080/10408398.2020.1763910
- eISSN
- 1549-7852
- Externe Identifier
- Clarivate Analytics Document Solution ID: RQ6AG
- PubMed Identifier: 32478608
- ISSN
- 1040-8398
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Schlüsselwörter
- Anticancer
- cancer therapy
- epigenetic
- flavonoids
- Paginierung
- 1616 - 1639
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Targeting epigenetics in cancer: therapeutic potential of flavonoids
- Sub types
- Review
- Ausgabe der Zeitschrift
- 61
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Haroon Khan
- Tarun Belwal
- Thomas Efferth
- Ammad Ahmad Farooqi
- Ana Sanches-Silva
- Rosa Anna Vacca
- Seyed Fazel Nabavi
- Fazlullah Khan
- Hari Prasad Devkota
- Davide Barreca
- Antoni Sureda
- Silvia Tejada
- Marco Dacrema
- Maria Daglia
- İpek Suntar
- Suowen Xu
- Hammad Ullah
- Maurizio Battino
- Francesca Giampieri
- Seyed Mohammad Nabavi
- DOI
- 10.1080/10408398.2020.1763910
- eISSN
- 1549-7852
- ISSN
- 1040-8398
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Critical Reviews in Food Science and Nutrition
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 1616 - 1639
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Informa UK Limited
- Herausgeber URL
- http://dx.doi.org/10.1080/10408398.2020.1763910
- Datum der Datenerfassung
- 2021
- Titel
- Targeting epigenetics in cancer: therapeutic potential of flavonoids
- Ausgabe der Zeitschrift
- 61
Data source: Crossref
- Abstract
- Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic incompliance, unwanted effects, and economic burdens imparted by cancer treatments, are primary health challenges. The heritable features in gene expression that are propagated through cell division and contribute to cellular identity without a change in DNA sequence are considered epigenetic characteristics and agents that could interfere with these features and are regarded as potential therapeutic targets. The genetic modification accounts for the recurrence and uncontrolled changes in the physiology of cancer cells. This review focuses on plant-derived flavonoids as a therapeutic tool for cancer, attributed to their ability for epigenetic regulation of cancer pathogenesis. The epigenetic mechanisms of various classes of flavonoids including flavonols, flavones, isoflavones, flavanones, flavan-3-ols, and anthocyanidins, such as cyanidin, delphinidin, and pelargonidin, are discussed. The outstanding results of preclinical studies encourage researchers to design several clinical trials on various flavonoids to ascertain their clinical strength in the treatment of different cancers. The results of such studies will define the clinical fate of these agents in future.
- Addresses
- Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan.
- Autoren
- Haroon Khan
- Tarun Belwal
- Thomas Efferth
- Thomas Efferth
- Ammad Ahmad Farooqi
- Ammad Ahmad Farooqi
- Ana Sanches-Silva
- Rosa Anna Vacca
- Seyed Fazel Nabavi
- Fazlullah Khan
- Hari Prasad Devkota
- Davide Barreca
- Antoni Sureda
- Silvia Tejada
- Marco Dacrema
- Maria Daglia
- İpek Suntar
- Suowen Xu
- Hammad Ullah
- Hammad Ullah
- Maurizio Battino
- Francesca Giampieri
- Seyed Mohammad Nabavi
- DOI
- 10.1080/10408398.2020.1763910
- eISSN
- 1549-7852
- Externe Identifier
- PubMed Identifier: 32478608
- Open access
- false
- ISSN
- 1040-8398
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Critical reviews in food science and nutrition
- Schlüsselwörter
- Humans
- Neoplasms
- Flavonoids
- Flavonols
- Diet
- Epigenesis, Genetic
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Paginierung
- 1616 - 1639
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- Targeting epigenetics in cancer: therapeutic potential of flavonoids.
- Sub types
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 61
Data source: Europe PubMed Central
- Abstract
- Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic incompliance, unwanted effects, and economic burdens imparted by cancer treatments, are primary health challenges. The heritable features in gene expression that are propagated through cell division and contribute to cellular identity without a change in DNA sequence are considered epigenetic characteristics and agents that could interfere with these features and are regarded as potential therapeutic targets. The genetic modification accounts for the recurrence and uncontrolled changes in the physiology of cancer cells. This review focuses on plant-derived flavonoids as a therapeutic tool for cancer, attributed to their ability for epigenetic regulation of cancer pathogenesis. The epigenetic mechanisms of various classes of flavonoids including flavonols, flavones, isoflavones, flavanones, flavan-3-ols, and anthocyanidins, such as cyanidin, delphinidin, and pelargonidin, are discussed. The outstanding results of preclinical studies encourage researchers to design several clinical trials on various flavonoids to ascertain their clinical strength in the treatment of different cancers. The results of such studies will define the clinical fate of these agents in future.
- Autoren
- Haroon Khan
- Tarun Belwal
- Thomas Efferth
- Ammad Ahmad Farooqi
- Ana Sanches-Silva
- Rosa Anna Vacca
- Seyed Fazel Nabavi
- Fazlullah Khan
- Hari Prasad Devkota
- Davide Barreca
- Antoni Sureda
- Silvia Tejada
- Marco Dacrema
- Maria Daglia
- İpek Suntar
- Suowen Xu
- Hammad Ullah
- Maurizio Battino
- Francesca Giampieri
- Seyed Mohammad Nabavi
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32478608
- DOI
- 10.1080/10408398.2020.1763910
- eISSN
- 1549-7852
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- Crit Rev Food Sci Nutr
- Schlüsselwörter
- Anticancer
- cancer therapy
- epigenetic
- flavonoids
- Diet
- Epigenesis, Genetic
- Flavonoids
- Flavonols
- Humans
- Neoplasms
- Sprache
- eng
- Country
- United States
- Paginierung
- 1616 - 1639
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Targeting epigenetics in cancer: therapeutic potential of flavonoids.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 61
Data source: PubMed
- Beziehungen:
- Property of