Steroidal saponins from Raphia vinifera and their cytotoxic activity

Publication type:
Journal article
Metadata:
Autoren
  • Godloves Fru Chi
  • Rodrigue VT Sop
  • Armelle T Mbaveng
  • Japheth Omollo Ombito
  • Ghislain Wabo Fotso
  • Gaelle S Nguenang
  • Victor Kuete
  • Thomas Efferth
  • Bonaventure T Ngadjui
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000579883100014&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.steroids.2020.108724
eISSN
1878-5867
Externe Identifier
  • Clarivate Analytics Document Solution ID: OD5HG
  • PubMed Identifier: 32889050
ISSN
0039-128X
Zeitschrift
STEROIDS
Schlüsselwörter
  • Raphia vinifera
  • Arecaceae
  • Steroidal saponin
  • Cytotoxicity
Artikelnummer
ARTN 108724
Datum der Veröffentlichung
2020
Status
Published
Titel
Steroidal saponins from <i>Raphia vinifera</i> and their cytotoxic activity
Sub types
  • Article
Ausgabe der Zeitschrift
163

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Godloves Fru Chi
  • Rodrigue VT Sop
  • Armelle T Mbaveng
  • Japheth Omollo Ombito
  • Ghislain Wabo Fotso
  • Gaëlle S Nguenang
  • Victor Kuete
  • Thomas Efferth
  • Bonaventure T Ngadjui
DOI
10.1016/j.steroids.2020.108724
ISSN
0039-128X
Zeitschrift
Steroids
Sprache
en
Artikelnummer
108724
Paginierung
108724 - 108724
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.steroids.2020.108724
Datum der Datenerfassung
2021
Titel
Steroidal saponins from Raphia vinifera and their cytotoxic activity
Ausgabe der Zeitschrift
163

Data source: Crossref

Abstract
Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC<sub>50</sub> values of 3.55 µM and 7.14 µM, respectively.
Addresses
  • Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana. Electronic address: chigfru@gmail.com.
Autoren
  • Godloves Fru Chi
  • Rodrigue VT Sop
  • Armelle T Mbaveng
  • Japheth Omollo Ombito
  • Ghislain Wabo Fotso
  • Gaëlle S Nguenang
  • Victor Kuete
  • Thomas Efferth
  • Bonaventure T Ngadjui
DOI
10.1016/j.steroids.2020.108724
eISSN
1878-5867
Externe Identifier
  • PubMed Identifier: 32889050
Funding acknowledgements
  • Alexander von Humboldt-Stiftung:
Open access
false
ISSN
0039-128X
Zeitschrift
Steroids
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Arecaceae
  • Steroids
  • Saponins
  • Antineoplastic Agents
  • Molecular Conformation
  • Models, Molecular
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Paginierung
108724
Datum der Veröffentlichung
2020
Status
Published
Datum der Datenerfassung
2020
Titel
Steroidal saponins from Raphia vinifera and their cytotoxic activity.
Sub types
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
163

Data source: Europe PubMed Central

Abstract
Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC50 values of 3.55 µM and 7.14 µM, respectively.
Date of acceptance
2020
Autoren
  • Godloves Fru Chi
  • Rodrigue VT Sop
  • Armelle T Mbaveng
  • Japheth Omollo Ombito
  • Ghislain Wabo Fotso
  • Gaëlle S Nguenang
  • Victor Kuete
  • Thomas Efferth
  • Bonaventure T Ngadjui
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32889050
DOI
10.1016/j.steroids.2020.108724
eISSN
1878-5867
Zeitschrift
Steroids
Schlüsselwörter
  • Arecaceae
  • Cytotoxicity
  • Raphia vinifera
  • Steroidal saponin
  • Antineoplastic Agents
  • Arecaceae
  • Cell Line, Tumor
  • Humans
  • Models, Molecular
  • Molecular Conformation
  • Saponins
  • Steroids
Sprache
eng
Country
United States
Paginierung
108724
PII
S0039-128X(20)30150-1
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Steroidal saponins from Raphia vinifera and their cytotoxic activity.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
163

Data source: PubMed

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