Salvia ceratophyllaL. from South of Jordan: new insights on chemical composition and biological activities
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Mohammad Sanad Abu-Darwish
- Celia Cabral
- Zulfigar Ali
- Mei Wang
- Shabana I Khan
- Melissa R Jacob
- Surendra K Jain
- Babu L Tekwani
- Fazila Zulfiqar
- Ikhlas A Khan
- Hatem Taifour
- Ligia Salgueiro
- Thomas Efferth
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000565026100001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1007/s13659-020-00259-9
- eISSN
- 2192-2209
- Externe Identifier
- Clarivate Analytics Document Solution ID: NT4YK
- PubMed Identifier: 32852722
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- NATURAL PRODUCTS AND BIOPROSPECTING
- Schlüsselwörter
- Lamiaceae
- Essential oil
- Chemical composition
- Cytotoxicity
- Anti-inflammatory activity
- Neglected diseases
- Paginierung
- 307 - 316
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- <i>Salvia ceratophylla</i>L. from South of Jordan: new insights on chemical composition and biological activities
- Sub types
- Article
- Ausgabe der Zeitschrift
- 10
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:title>Abstract</jats:title><jats:p>In Jordan, <jats:italic>Salvia ceratophylla</jats:italic> L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize <jats:italic>S. ceratophylla</jats:italic> essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC–MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it’s predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC<jats:sub>50</jats:sub> between 60 and > 100 µg/mL. The EO inhibited NO production (IC<jats:sub>50</jats:sub> 90 µg/mL) and NF-κB activity (IC<jats:sub>50</jats:sub> 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC<jats:sub>50</jats:sub> between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC<jats:sub>50</jats:sub> 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC<jats:sub>50</jats:sub> 2.65 µg/mL. In conclusion, Jordan <jats:italic>S. ceratophylla</jats:italic> EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.</jats:p>
- Autoren
- Mohammad Sanad Abu-Darwish
- Célia Cabral
- Zulfigar Ali
- Mei Wang
- Shabana I Khan
- Melissa R Jacob
- Surendra K Jain
- Babu L Tekwani
- Fazila Zulfiqar
- Ikhlas A Khan
- Hatem Taifour
- Lígia Salgueiro
- Thomas Efferth
- DOI
- 10.1007/s13659-020-00259-9
- eISSN
- 2192-2209
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Natural Products and Bioprospecting
- Sprache
- en
- Online publication date
- 2020
- Paginierung
- 307 - 316
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Herausgeber
- Springer Science and Business Media LLC
- Herausgeber URL
- http://dx.doi.org/10.1007/s13659-020-00259-9
- Datum der Datenerfassung
- 2021
- Titel
- Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Abstract
- In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC<sub>50</sub> between 60 and > 100 µg/mL. The EO inhibited NO production (IC<sub>50</sub> 90 µg/mL) and NF-κB activity (IC<sub>50</sub> 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC<sub>50</sub> between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC<sub>50</sub> 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC<sub>50</sub> 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
- Addresses
- Department of Basic and Applied Sciences, Al-Balqa Applied University, Al-Salt, 19117, Jordan.
- Autoren
- Mohammad Sanad Abu-Darwish
- Célia Cabral
- Zulfigar Ali
- Mei Wang
- Shabana I Khan
- Melissa R Jacob
- Surendra K Jain
- Babu L Tekwani
- Fazila Zulfiqar
- Ikhlas A Khan
- Hatem Taifour
- Lígia Salgueiro
- Thomas Efferth
- DOI
- 10.1007/s13659-020-00259-9
- eISSN
- 2192-2209
- Externe Identifier
- PubMed Identifier: 32852722
- PubMed Central ID: PMC7520468
- Funding acknowledgements
- Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul:
- US-UK Fulbright Commission:
- Open access
- true
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Natural products and bioprospecting
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Open access status
- Open Access
- Paginierung
- 307 - 316
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2020
- Titel
- Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities.
- Sub types
- research-article
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://link.springer.com/content/pdf/10.1007/s13659-020-00259-9.pdf https://europepmc.org/articles/PMC7520468?pdf=render
Data source: Europe PubMed Central
- Abstract
- In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it's predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC50 90 µg/mL) and NF-κB activity (IC50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
- Date of acceptance
- 2020
- Autoren
- Mohammad Sanad Abu-Darwish
- Célia Cabral
- Zulfigar Ali
- Mei Wang
- Shabana I Khan
- Melissa R Jacob
- Surendra K Jain
- Babu L Tekwani
- Fazila Zulfiqar
- Ikhlas A Khan
- Hatem Taifour
- Lígia Salgueiro
- Thomas Efferth
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/32852722
- DOI
- 10.1007/s13659-020-00259-9
- Externe Identifier
- PubMed Central ID: PMC7520468
- ISSN
- 2192-2195
- Ausgabe der Veröffentlichung
- 5
- Zeitschrift
- Nat Prod Bioprospect
- Schlüsselwörter
- Anti-inflammatory activity
- Chemical composition
- Cytotoxicity
- Essential oil
- Lamiaceae
- Neglected diseases
- Sprache
- eng
- Country
- Germany
- Paginierung
- 307 - 316
- PII
- 10.1007/s13659-020-00259-9
- Datum der Veröffentlichung
- 2020
- Status
- Published
- Titel
- Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities.
- Sub types
- Journal Article
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
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