Multiple modes of cell death in neuroendocrine tumors induced by artesunate

Publication type:
Journal article
Metadata:
Autoren
  • Ge Yan
  • Mona Dawood
  • Madeleine Boeckers
  • Sabine M Klauck
  • Christian Fottner
  • Matthias M Weber
  • Thomas Efferth
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000581562000012&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2020.153332
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: OG0BW
  • PubMed Identifier: 32957040
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Artesunate
  • Neuroendocrine
  • Cellular response
  • Cell death
  • Resistance
Artikelnummer
ARTN 153332
Datum der Veröffentlichung
2020
Status
Published
Titel
Multiple modes of cell death in neuroendocrine tumors induced by artesunate
Sub types
  • Article
Ausgabe der Zeitschrift
79

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Ge Yan
  • Mona Dawood
  • Madeleine Böckers
  • Sabine M Klauck
  • Christian Fottner
  • Matthias M Weber
  • Thomas Efferth
DOI
10.1016/j.phymed.2020.153332
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153332
Paginierung
153332 - 153332
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2020.153332
Datum der Datenerfassung
2020
Titel
Multiple modes of cell death in neuroendocrine tumors induced by artesunate
Ausgabe der Zeitschrift
79

Data source: Crossref

Abstract
<h4>Background</h4>The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile.<h4>Methods</h4>We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels.<h4>Results</h4>Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sensitivities presented on the three cell lines also associated with a differential regulation of p21 on the long run. Co-treatment with p21 inhibitor UC2288 showed an additive effect on QGP-1 and NCI-H727 cell lines indicating p21 upregulation in these two cell lines might confer resistance towards ART treatment.<h4>Conclusions</h4>It is possible to include ART in the treatment of NETs in the future.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Autoren
  • Ge Yan
  • Mona Dawood
  • Madeleine Böckers
  • Sabine M Klauck
  • Christian Fottner
  • Matthias M Weber
  • Thomas Efferth
DOI
10.1016/j.phymed.2020.153332
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 32957040
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: GRK 2015/2
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Neuroendocrine Tumors
  • Phenylurea Compounds
  • Niacinamide
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis
  • Autophagy
  • Cyclin-Dependent Kinase Inhibitor p21
  • Endoplasmic Reticulum Stress
  • Artesunate
  • Ferroptosis
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Paginierung
153332
Datum der Veröffentlichung
2020
Status
Published
Datum der Datenerfassung
2020
Titel
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
79

Data source: Europe PubMed Central

Abstract
BACKGROUND: The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. METHODS: We evaluated the impact of ART on three NET cell lines, BON-1, QGP-1 and NCI-H727 on cellular and molecular levels. RESULTS: Our results showed that ART induced endoplasmic reticulum (ER) stress through phosphorylation of eIF2α, which further gave rise to autophagy in all three NET cell lines. Specifically, apoptosis and ferroptosis were also observed in BON-1 cells, which made BON-1 cell line more vulnerable upon ART treatment. The different sensitivities presented on the three cell lines also associated with a differential regulation of p21 on the long run. Co-treatment with p21 inhibitor UC2288 showed an additive effect on QGP-1 and NCI-H727 cell lines indicating p21 upregulation in these two cell lines might confer resistance towards ART treatment. CONCLUSIONS: It is possible to include ART in the treatment of NETs in the future.
Date of acceptance
2020
Autoren
  • Ge Yan
  • Mona Dawood
  • Madeleine Böckers
  • Sabine M Klauck
  • Christian Fottner
  • Matthias M Weber
  • Thomas Efferth
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/32957040
DOI
10.1016/j.phymed.2020.153332
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Artesunate
  • Cell death
  • Cellular response
  • Neuroendocrine
  • Resistance
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis
  • Artesunate
  • Autophagy
  • Cell Line, Tumor
  • Cyclin-Dependent Kinase Inhibitor p21
  • Endoplasmic Reticulum Stress
  • Ferroptosis
  • Humans
  • Neuroendocrine Tumors
  • Niacinamide
  • Phenylurea Compounds
Sprache
eng
Country
Germany
Paginierung
153332
PII
S0944-7113(20)30164-1
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2020
Titel
Multiple modes of cell death in neuroendocrine tumors induced by artesunate.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
79

Data source: PubMed

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