Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Shaden AM Khalifa
- Nermeen Yosri
- Mohamed F El-Mallah
- Reem Ghonaim
- Zhiming Guo
- Syed Ghulam Musharraf
- Ming Du
- Alfi Khatib
- Jianbo Xiao
- Aamer Saeed
- Haged HR El-Seedi
- Chao Zhao
- Thomas Efferth
- Hesham R El-Seedi
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000640107200009&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.phymed.2020.153311
- eISSN
- 1618-095X
- Externe Identifier
- Clarivate Analytics Document Solution ID: RN1IG
- PubMed Identifier: 33067112
- ISSN
- 0944-7113
- Zeitschrift
- PHYTOMEDICINE
- Schlüsselwörter
- COVID-19
- Natural products
- Antiviral
- Clinical trials
- Patent
- Protection
- Artikelnummer
- ARTN 153311
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic
- Sub types
- Review
- Ausgabe der Zeitschrift
- 85
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Shaden AM Khalifa
- Nermeen Yosri
- Mohamed F El-Mallah
- Reem Ghonaim
- Zhiming Guo
- Syed Ghulam Musharraf
- Ming Du
- Alfi Khatib
- Jianbo Xiao
- Aamer Saeed
- Haged HR El-Seedi
- Chao Zhao
- Thomas Efferth
- Hesham R El-Seedi
- DOI
- 10.1016/j.phymed.2020.153311
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine
- Sprache
- en
- Artikelnummer
- 153311
- Paginierung
- 153311 - 153311
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.phymed.2020.153311
- Datum der Datenerfassung
- 2022
- Titel
- Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic
- Ausgabe der Zeitschrift
- 85
Data source: Crossref
- Abstract
- <h4>Background</h4>Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge.<h4>Methods</h4>A literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar).<h4>Results</h4>Through the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'Hér.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab.<h4>Conclusion</h4>Natural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.
- Addresses
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91, Stockholm, Sweden.
- Autoren
- Shaden AM Khalifa
- Nermeen Yosri
- Mohamed F El-Mallah
- Reem Ghonaim
- Zhiming Guo
- Syed Ghulam Musharraf
- Ming Du
- Alfi Khatib
- Jianbo Xiao
- Aamer Saeed
- Haged HR El-Seedi
- Chao Zhao
- Thomas Efferth
- Hesham R El-Seedi
- DOI
- 10.1016/j.phymed.2020.153311
- eISSN
- 1618-095X
- Externe Identifier
- PubMed Identifier: 33067112
- PubMed Central ID: PMC7455571
- Funding acknowledgements
- Swedish Research Council:
- Open access
- true
- ISSN
- 0944-7113
- Zeitschrift
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Schlüsselwörter
- Humans
- Plant Preparations
- Biological Products
- Antiviral Agents
- Drug Evaluation, Preclinical
- Molecular Structure
- Clinical Trials as Topic
- Pandemics
- SARS-CoV-2
- COVID-19 Vaccines
- COVID-19 Drug Treatment
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Open access status
- Open Access
- Paginierung
- 153311
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2020
- Titel
- Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 85
Files
https://europepmc.org/articles/PMC7455571?pdf=render
Data source: Europe PubMed Central
- Abstract
- BACKGROUND: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. The health organizations and global care systems screened the available resources and offered recommendations of approved and proposed medications. However, the search for a specific selective therapy or vaccine against COVID-19 remains a challenge. METHODS: A literature search was performed for the screening of natural and derived bio-active compounds which showed potent antiviral activity against coronaviruses using published articles, patents, clinical trials website (https://clinicaltrials.gov/) and web databases (PubMed, SCI Finder, Science Direct, and Google Scholar). RESULTS: Through the screening for natural products with antiviral activities against different types of the human coronavirus, extracts of Lycoris radiata (L'Hér.), Gentiana scabra Bunge, Dioscorea batatas Decne., Cassia tora L., Taxillus chinensis (DC.), Cibotium barometz L. and Echinacea purpurea L. showed a promising effect against SARS-CoV. Out of the listed compound Lycorine, emetine dihydrochloride hydrate, pristimerin, harmine, conessine, berbamine, 4`-hydroxychalcone, papaverine, mycophenolic acid, mycophenolate mofetil, monensin sodium, cycloheximide, oligomycin and valinomycin show potent activity against human coronaviruses. Additionally, it is worth noting that some compounds have already moved into clinical trials for their activity against COVID-19 including fingolimod, methylprednisolone, chloroquine, tetrandrine and tocilizumab. CONCLUSION: Natural compounds and their derivatives could be used for developing potent therapeutics with significant activity against SARS-COV-2, providing a promising frontline in the fighting against COVID-19.
- Date of acceptance
- 2020
- Autoren
- Shaden AM Khalifa
- Nermeen Yosri
- Mohamed F El-Mallah
- Reem Ghonaim
- Zhiming Guo
- Syed Ghulam Musharraf
- Ming Du
- Alfi Khatib
- Jianbo Xiao
- Aamer Saeed
- Haged HR El-Seedi
- Chao Zhao
- Thomas Efferth
- Hesham R El-Seedi
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33067112
- DOI
- 10.1016/j.phymed.2020.153311
- eISSN
- 1618-095X
- Externe Identifier
- PubMed Central ID: PMC7455571
- Zeitschrift
- Phytomedicine
- Schlüsselwörter
- Antiviral
- COVID-19
- Clinical trials
- Natural products
- Patent
- Protection
- Antiviral Agents
- Biological Products
- COVID-19 Vaccines
- Clinical Trials as Topic
- Drug Evaluation, Preclinical
- Humans
- Molecular Structure
- Pandemics
- Plant Preparations
- SARS-CoV-2
- COVID-19 Drug Treatment
- Sprache
- eng
- Country
- Germany
- Paginierung
- 153311
- PII
- S0944-7113(20)30143-4
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2021
- Titel
- Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 85
Data source: PubMed
- Beziehungen:
- Property of