Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Srimanta Patra
- Biswajita Pradhan
- Rabindra Nayak
- Chhandashree Behera
- Laxmidhar Rout
- Mrutyunjay Jena
- Thomas Efferth
- Sujit Kumar Bhutia
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000661238700005&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.1016/j.semcancer.2020.10.010
- eISSN
- 1096-3650
- Externe Identifier
- Clarivate Analytics Document Solution ID: SR7PW
- PubMed Identifier: 33152486
- ISSN
- 1044-579X
- Zeitschrift
- SEMINARS IN CANCER BIOLOGY
- Schlüsselwörter
- Curcumin
- Resveratrol
- Chemoprotection
- Chemoprevention
- Pharmacokinetics
- Paginierung
- 310 - 320
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics
- Sub types
- Article
- Ausgabe der Zeitschrift
- 73
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Autoren
- Srimanta Patra
- Biswajita Pradhan
- Rabindra Nayak
- Chhandashree Behera
- Laxmidhar Rout
- Mrutyunjay Jena
- Thomas Efferth
- Sujit Kumar Bhutia
- DOI
- 10.1016/j.semcancer.2020.10.010
- ISSN
- 1044-579X
- Zeitschrift
- Seminars in Cancer Biology
- Sprache
- en
- Paginierung
- 310 - 320
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Elsevier BV
- Herausgeber URL
- http://dx.doi.org/10.1016/j.semcancer.2020.10.010
- Datum der Datenerfassung
- 2022
- Titel
- Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics
- Ausgabe der Zeitschrift
- 73
Data source: Crossref
- Abstract
- The frequent inefficiency of conventional cancer therapies due to drug resistance, non-targeted drug delivery, chemotherapy-associated toxic side effects turned the focus to bioactive phytochemicals. In this context, curcumin and resveratrol have emerged as potent chemopreventive and chemoprotective compounds modulating apoptotic and autophagic cell death pathways in cancer in vitro and in vivo. As synergistic agents in combination with clinically established anticancer drugs, the enhanced anticancer activity at reduced chemotherapy-associated toxicity towards normal organs can be explained by improved pharmacokinetics, pharmacodynamics, bioavailability and metabolism. With promising preclinical and clinical applications, the design of drug-loaded nanoparticles, nanocarriers, liposomes and micelles have gained much attention to improve target specificity and drug efficacy. The present review focuses on the molecular modes of chemoprevention, chemoprotection and drug synergism with special emphasis to preclinical and clinical applications, pharmacokinetics, pharmacodynamics and advanced drug delivery methods for the development of next-generation personalized cancer therapeutics.
- Addresses
- Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, India.
- Autoren
- Srimanta Patra
- Biswajita Pradhan
- Rabindra Nayak
- Chhandashree Behera
- Laxmidhar Rout
- Mrutyunjay Jena
- Thomas Efferth
- Sujit Kumar Bhutia
- DOI
- 10.1016/j.semcancer.2020.10.010
- eISSN
- 1096-3650
- Externe Identifier
- PubMed Identifier: 33152486
- Funding acknowledgements
- Council of Scientific and Industrial Research, India:
- Open access
- false
- ISSN
- 1044-579X
- Zeitschrift
- Seminars in cancer biology
- Schlüsselwörter
- Animals
- Humans
- Neoplasms
- Curcumin
- Antineoplastic Agents, Phytogenic
- Chemoprevention
- Drug Synergism
- Phytochemicals
- Resveratrol
- Sprache
- eng
- Medium
- Print-Electronic
- Online publication date
- 2020
- Paginierung
- 310 - 320
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum der Datenerfassung
- 2020
- Titel
- Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics.
- Sub types
- Research Support, Non-U.S. Gov't
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 73
Data source: Europe PubMed Central
- Abstract
- The frequent inefficiency of conventional cancer therapies due to drug resistance, non-targeted drug delivery, chemotherapy-associated toxic side effects turned the focus to bioactive phytochemicals. In this context, curcumin and resveratrol have emerged as potent chemopreventive and chemoprotective compounds modulating apoptotic and autophagic cell death pathways in cancer in vitro and in vivo. As synergistic agents in combination with clinically established anticancer drugs, the enhanced anticancer activity at reduced chemotherapy-associated toxicity towards normal organs can be explained by improved pharmacokinetics, pharmacodynamics, bioavailability and metabolism. With promising preclinical and clinical applications, the design of drug-loaded nanoparticles, nanocarriers, liposomes and micelles have gained much attention to improve target specificity and drug efficacy. The present review focuses on the molecular modes of chemoprevention, chemoprotection and drug synergism with special emphasis to preclinical and clinical applications, pharmacokinetics, pharmacodynamics and advanced drug delivery methods for the development of next-generation personalized cancer therapeutics.
- Date of acceptance
- 2020
- Autoren
- Srimanta Patra
- Biswajita Pradhan
- Rabindra Nayak
- Chhandashree Behera
- Laxmidhar Rout
- Mrutyunjay Jena
- Thomas Efferth
- Sujit Kumar Bhutia
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/33152486
- DOI
- 10.1016/j.semcancer.2020.10.010
- eISSN
- 1096-3650
- Zeitschrift
- Semin Cancer Biol
- Schlüsselwörter
- Chemoprevention
- Chemoprotection
- Curcumin
- Pharmacokinetics
- Resveratrol
- Animals
- Antineoplastic Agents, Phytogenic
- Chemoprevention
- Curcumin
- Drug Synergism
- Humans
- Neoplasms
- Phytochemicals
- Resveratrol
- Sprache
- eng
- Country
- England
- Paginierung
- 310 - 320
- PII
- S1044-579X(20)30215-7
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Titel
- Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics.
- Sub types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
- Ausgabe der Zeitschrift
- 73
Data source: PubMed
- Beziehungen:
- Property of