Genomic landscape analyses in cervical carcinoma and consequences for treatment

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000605587100016&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.coph.2020.09.013
eISSN
1471-4973
Externe Identifier
  • Clarivate Analytics Document Solution ID: PP0VB
  • PubMed Identifier: 33166910
ISSN
1471-4892
Zeitschrift
CURRENT OPINION IN PHARMACOLOGY
Paginierung
142 - 157
Datum der Veröffentlichung
2020
Status
Published
Titel
Genomic landscape analyses in cervical carcinoma and consequences for treatment
Sub types
  • Review
Ausgabe der Zeitschrift
54

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.coph.2020.09.013
ISSN
1471-4892
Zeitschrift
Current Opinion in Pharmacology
Sprache
en
Paginierung
142 - 157
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.coph.2020.09.013
Datum der Datenerfassung
2021
Titel
Genomic landscape analyses in cervical carcinoma and consequences for treatment
Ausgabe der Zeitschrift
54

Data source: Crossref

Abstract
Where we are on the road to 'tailor-made' precision medicine for drug-resistant cervical carcinoma? We explored studies about analyses of viral and human genomes, epigenomes and transcriptomes, DNA mutation analyses, their importance in detecting HPV sequences, mechanisms of drug resistance to established and targeted therapies with small molecule or therapeutic antibodies, to radiosensitivity and to chemoradiotherapy. The value of repurposing of old drugs initially approved for other disease indications and now considered for cervix cancer therapy is also discussed. The microbiome influences drug response and survival too. HPV genomic integration sites were less significant. Nomograms (Lee et al., 2013) even outperformed FIGO staging regarding prediction of five-year overall survival times. We conclude that there are still many loose threads to be followed up, before coherent conclusions for individualized therapy of drug-resistant cervical carcinoma can be drawn.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany.
Autoren
DOI
10.1016/j.coph.2020.09.013
eISSN
1471-4973
Externe Identifier
  • PubMed Identifier: 33166910
Open access
false
ISSN
1471-4892
Zeitschrift
Current opinion in pharmacology
Schlüsselwörter
  • Animals
  • Humans
  • Papillomaviridae
  • DNA
  • Prognosis
  • Genomics
  • Uterine Cervical Neoplasms
  • Female
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Paginierung
142 - 157
Datum der Veröffentlichung
2020
Status
Published
Datum der Datenerfassung
2020
Titel
Genomic landscape analyses in cervical carcinoma and consequences for treatment.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
54

Data source: Europe PubMed Central

Abstract
Where we are on the road to 'tailor-made' precision medicine for drug-resistant cervical carcinoma? We explored studies about analyses of viral and human genomes, epigenomes and transcriptomes, DNA mutation analyses, their importance in detecting HPV sequences, mechanisms of drug resistance to established and targeted therapies with small molecule or therapeutic antibodies, to radiosensitivity and to chemoradiotherapy. The value of repurposing of old drugs initially approved for other disease indications and now considered for cervix cancer therapy is also discussed. The microbiome influences drug response and survival too. HPV genomic integration sites were less significant. Nomograms (Lee et al., 2013) even outperformed FIGO staging regarding prediction of five-year overall survival times. We conclude that there are still many loose threads to be followed up, before coherent conclusions for individualized therapy of drug-resistant cervical carcinoma can be drawn.
Date of acceptance
2020
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33166910
DOI
10.1016/j.coph.2020.09.013
eISSN
1471-4973
Zeitschrift
Curr Opin Pharmacol
Schlüsselwörter
  • Animals
  • DNA
  • Female
  • Genomics
  • Humans
  • Papillomaviridae
  • Prognosis
  • Uterine Cervical Neoplasms
Sprache
eng
Country
England
Paginierung
142 - 157
PII
S1471-4892(20)30094-1
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Genomic landscape analyses in cervical carcinoma and consequences for treatment.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
54

Data source: PubMed

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