Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000628984700029&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1039/d0fo02208j
eISSN
2042-650X
Externe Identifier
  • Clarivate Analytics Document Solution ID: QW9RH
  • PubMed Identifier: 33596295
ISSN
2042-6496
Ausgabe der Veröffentlichung
5
Zeitschrift
FOOD & FUNCTION
Paginierung
2242 - 2256
Datum der Veröffentlichung
2021
Status
Published
Titel
Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in <i>C. elegans</i> serotonin-deficient mutants
Sub types
  • Article
Ausgabe der Zeitschrift
12

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<p>UA acts through serotonin receptors to enhance stress resistance and prolong life span in <italic>C. elegans</italic>.</p>
Autoren
DOI
10.1039/d0fo02208j
eISSN
2042-650X
ISSN
2042-6496
Ausgabe der Veröffentlichung
5
Zeitschrift
Food &amp; Function
Sprache
en
Online publication date
2021
Paginierung
2242 - 2256
Status
Published online
Herausgeber
Royal Society of Chemistry (RSC)
Herausgeber URL
http://dx.doi.org/10.1039/d0fo02208j
Datum der Datenerfassung
2024
Titel
Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in <i>C. elegans</i> serotonin-deficient mutants
Ausgabe der Zeitschrift
12

Data source: Crossref

Abstract
<h4>Introduction</h4>Depression and anxiety disorders contribute to the global disease burden. Ursolic acid (UA), a natural compound present in many vegetables, fruits and medicinal plants, was tested in vivo for its effect on (1) enhancing resistance to stress and (2) its effect on life span.<h4>Methods</h4>The compound was tested for its antioxidant activity in C. elegans. Stress resistance was tested in the heat and osmotic stress assay. Additionally, the influence on normal life span was examined. RT-PCR was used to assess possible serotonin targets.<h4>Results</h4>UA prolonged the life span of C. elegans. Additionally, UA significantly lowered reactive oxygen species (ROS). Molecular docking studies, PCR analysis and microscale thermophoresis (MST) supported the results that UA acts through serotonin receptors to enhance stress resistance.<h4>Discussion</h4>Considering the urgent need for new and safe medications in the treatment of depression and anxiety disorders, our results indicate that UA may be a promising new drug candidate.
Addresses
  • Department of Pharmaceutical Biology, Institute of Biochemistry and Pharmacy, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. efferth@uni-mainz.de.
Autoren
DOI
10.1039/d0fo02208j
eISSN
2042-650X
Externe Identifier
  • PubMed Identifier: 33596295
Funding acknowledgements
  • Office of Research Infrastructure Programs, National Institutes of Health: P40 OD010440
  • Deutsche Forschungsgemeinschaft: DFG GRK 2015/1
Open access
false
ISSN
2042-6496
Ausgabe der Veröffentlichung
5
Zeitschrift
Food & function
Schlüsselwörter
  • Animals
  • Caenorhabditis elegans
  • Disease Models, Animal
  • Reactive Oxygen Species
  • Serotonin
  • Triterpenes
  • Naphthoquinones
  • Receptors, Serotonin
  • Antioxidants
  • Depression
  • Longevity
  • Mutation
  • Osmotic Pressure
  • Models, Molecular
  • Hot Temperature
  • Stress, Physiological
  • Molecular Docking Simulation
  • Ursolic Acid
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
2242 - 2256
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: Europe PubMed Central

Abstract
INTRODUCTION: Depression and anxiety disorders contribute to the global disease burden. Ursolic acid (UA), a natural compound present in many vegetables, fruits and medicinal plants, was tested in vivo for its effect on (1) enhancing resistance to stress and (2) its effect on life span. METHODS: The compound was tested for its antioxidant activity in C. elegans. Stress resistance was tested in the heat and osmotic stress assay. Additionally, the influence on normal life span was examined. RT-PCR was used to assess possible serotonin targets. RESULTS: UA prolonged the life span of C. elegans. Additionally, UA significantly lowered reactive oxygen species (ROS). Molecular docking studies, PCR analysis and microscale thermophoresis (MST) supported the results that UA acts through serotonin receptors to enhance stress resistance. DISCUSSION: Considering the urgent need for new and safe medications in the treatment of depression and anxiety disorders, our results indicate that UA may be a promising new drug candidate.
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33596295
DOI
10.1039/d0fo02208j
eISSN
2042-650X
Ausgabe der Veröffentlichung
5
Zeitschrift
Food Funct
Schlüsselwörter
  • Animals
  • Antioxidants
  • Caenorhabditis elegans
  • Depression
  • Disease Models, Animal
  • Hot Temperature
  • Longevity
  • Models, Molecular
  • Molecular Docking Simulation
  • Mutation
  • Naphthoquinones
  • Osmotic Pressure
  • Reactive Oxygen Species
  • Receptors, Serotonin
  • Serotonin
  • Stress, Physiological
  • Triterpenes
  • Ursolic Acid
Sprache
eng
Country
England
Paginierung
2242 - 2256
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
12

Data source: PubMed

Beziehungen:
Property of

Tools