Multi-omics approaches to improve malaria therapy

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000643618900040&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phrs.2021.105570
eISSN
1096-1186
Externe Identifier
  • Clarivate Analytics Document Solution ID: RS2NO
  • PubMed Identifier: 33766628
ISSN
1043-6618
Zeitschrift
PHARMACOLOGICAL RESEARCH
Schlüsselwörter
  • Drug development
  • Drug resistance
  • Infectious diseases
  • Plasmodium
  • Treatment targets
  • Vaccine
  • Vector-borne disease
Artikelnummer
ARTN 105570
Datum der Veröffentlichung
2021
Status
Published
Titel
Multi-omics approaches to improve malaria therapy
Sub types
  • Review
Ausgabe der Zeitschrift
167

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phrs.2021.105570
ISSN
1043-6618
Zeitschrift
Pharmacological Research
Sprache
en
Artikelnummer
105570
Paginierung
105570 - 105570
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phrs.2021.105570
Datum der Datenerfassung
2023
Titel
Multi-omics approaches to improve malaria therapy
Ausgabe der Zeitschrift
167

Data source: Crossref

Abstract
Malaria contributes to the most widespread infectious diseases worldwide. Even though current drugs are commercially available, the ever-increasing drug resistance problem by malaria parasites poses new challenges in malaria therapy. Hence, searching for efficient therapeutic strategies is of high priority in malaria control. In recent years, multi-omics technologies have been extensively applied to provide a more holistic view of functional principles and dynamics of biological mechanisms. We briefly review multi-omics technologies and focus on recent malaria progress conducted with the help of various omics methods. Then, we present up-to-date advances for multi-omics approaches in malaria. Next, we describe resistance phenomena to established antimalarial drugs and underlying mechanisms. Finally, we provide insight into novel multi-omics approaches, new drugs and vaccine developments and analyze current gaps in multi-omics research. Although multi-omics approaches have been successfully used in malaria studies, they are still limited. Many gaps need to be filled to bridge the gap between basic research and treatment of malaria patients. Multi-omics approaches will foster a better understanding of the molecular mechanisms of Plasmodium that are essential for the development of novel drugs and vaccines to fight this disastrous disease.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Autoren
DOI
10.1016/j.phrs.2021.105570
eISSN
1096-1186
Externe Identifier
  • PubMed Identifier: 33766628
Funding acknowledgements
  • Republic of Turkey Ministry of National Education:
Open access
false
ISSN
1043-6618
Zeitschrift
Pharmacological research
Schlüsselwörter
  • Animals
  • Humans
  • Plasmodium
  • Malaria
  • Antimalarials
  • Proteomics
  • Genomics
  • Drug Resistance
  • Metabolomics
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
105570
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Multi-omics approaches to improve malaria therapy.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
167

Data source: Europe PubMed Central

Abstract
Malaria contributes to the most widespread infectious diseases worldwide. Even though current drugs are commercially available, the ever-increasing drug resistance problem by malaria parasites poses new challenges in malaria therapy. Hence, searching for efficient therapeutic strategies is of high priority in malaria control. In recent years, multi-omics technologies have been extensively applied to provide a more holistic view of functional principles and dynamics of biological mechanisms. We briefly review multi-omics technologies and focus on recent malaria progress conducted with the help of various omics methods. Then, we present up-to-date advances for multi-omics approaches in malaria. Next, we describe resistance phenomena to established antimalarial drugs and underlying mechanisms. Finally, we provide insight into novel multi-omics approaches, new drugs and vaccine developments and analyze current gaps in multi-omics research. Although multi-omics approaches have been successfully used in malaria studies, they are still limited. Many gaps need to be filled to bridge the gap between basic research and treatment of malaria patients. Multi-omics approaches will foster a better understanding of the molecular mechanisms of Plasmodium that are essential for the development of novel drugs and vaccines to fight this disastrous disease.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33766628
DOI
10.1016/j.phrs.2021.105570
eISSN
1096-1186
Zeitschrift
Pharmacol Res
Schlüsselwörter
  • Drug development
  • Drug resistance
  • Infectious diseases
  • Plasmodium
  • Treatment targets
  • Vaccine
  • Vector-borne disease
  • Animals
  • Antimalarials
  • Drug Resistance
  • Genomics
  • Humans
  • Malaria
  • Metabolomics
  • Plasmodium
  • Proteomics
Sprache
eng
Country
Netherlands
Paginierung
105570
PII
S1043-6618(21)00154-7
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Multi-omics approaches to improve malaria therapy.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
167

Data source: PubMed

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