Increased Stress Resistance and Lifespan in Chaenorhabditis elegans Wildtype and Knockout Mutants-Implications for Depression Treatment by Medicinal Herbs

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000638734700001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.3390/molecules26071827
eISSN
1420-3049
Externe Identifier
  • Clarivate Analytics Document Solution ID: RL1IC
  • PubMed Identifier: 33805024
Ausgabe der Veröffentlichung
7
Zeitschrift
MOLECULES
Schlüsselwörter
  • ageing
  • C
  • elegans
  • depression
  • phytochemical
  • phytotherapy
  • stress
Artikelnummer
ARTN 1827
Datum der Veröffentlichung
2021
Status
Published
Titel
Increased Stress Resistance and Lifespan in <i>Chaenorhabditis elegans</i> Wildtype and Knockout Mutants-Implications for Depression Treatment by Medicinal Herbs
Sub types
  • Article
Ausgabe der Zeitschrift
26

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p>Depression and anxiety disorders are widespread diseases, and they belong to the leading causes of disability and greatest burdens on healthcare systems worldwide. It is expected that the numbers will dramatically rise during the COVID-19 pandemic. Established medications are not sufficient to adequately treat depression and are not available for everyone. Plants from traditional medicine may be promising alternatives to treat depressive symptoms. The model organism Chaenorhabditis elegans was used to assess the stress reducing effects of methanol/dichlormethane extracts from plants used in traditional medicine. After initial screening for antioxidant activity, nine extracts were selected for in vivo testing in oxidative stress, heat stress, and osmotic stress assays. Additionally, anti-aging properties were evaluated in lifespan assay. The extracts from Acanthopanax senticosus, Campsis grandiflora, Centella asiatica, Corydalis yanhusuo, Dan Zhi, Houttuynia cordata, Psoralea corylifolia, Valeriana officinalis, and Withaniasomnifera showed antioxidant activity of more than 15 Trolox equivalents per mg extract. The extracts significantly lowered ROS in mutants, increased resistance to heat stress and osmotic stress, and the extended lifespan of the nematodes. The plant extracts tested showed promising results in increasing stress resistance in the nematode model. Further analyses are needed, in order to unravel underlying mechanisms and transfer results to humans.</jats:p>
Autoren
DOI
10.3390/molecules26071827
eISSN
1420-3049
Ausgabe der Veröffentlichung
7
Zeitschrift
Molecules
Sprache
en
Online publication date
2021
Paginierung
1827 - 1827
Status
Published online
Herausgeber
MDPI AG
Herausgeber URL
http://dx.doi.org/10.3390/molecules26071827
Datum der Datenerfassung
2021
Titel
Increased Stress Resistance and Lifespan in Chaenorhabditis elegans Wildtype and Knockout Mutants—Implications for Depression Treatment by Medicinal Herbs
Ausgabe der Zeitschrift
26

Data source: Crossref

Abstract
Depression and anxiety disorders are widespread diseases, and they belong to the leading causes of disability and greatest burdens on healthcare systems worldwide. It is expected that the numbers will dramatically rise during the COVID-19 pandemic. Established medications are not sufficient to adequately treat depression and are not available for everyone. Plants from traditional medicine may be promising alternatives to treat depressive symptoms. The model organism <i>Chaenorhabditis elegans</i> was used to assess the stress reducing effects of methanol/dichlormethane extracts from plants used in traditional medicine. After initial screening for antioxidant activity, nine extracts were selected for in vivo testing in oxidative stress, heat stress, and osmotic stress assays. Additionally, anti-aging properties were evaluated in lifespan assay. The extracts from <i>Acanthopanax senticosus, Campsis grandiflora, Centella asiatica, Corydalis yanhusuo, Dan Zhi, Houttuynia cordata, Psoralea corylifolia, Valeriana officinalis</i>, and <i>Withania</i><i>somnifera</i> showed antioxidant activity of more than 15 Trolox equivalents per mg extract. The extracts significantly lowered ROS in mutants, increased resistance to heat stress and osmotic stress, and the extended lifespan of the nematodes. The plant extracts tested showed promising results in increasing stress resistance in the nematode model. Further analyses are needed, in order to unravel underlying mechanisms and transfer results to humans.
Addresses
  • Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Autoren
DOI
10.3390/molecules26071827
eISSN
1420-3049
Externe Identifier
  • PubMed Identifier: 33805024
  • PubMed Central ID: PMC8036369
Open access
true
ISSN
1420-3049
Ausgabe der Veröffentlichung
7
Zeitschrift
Molecules (Basel, Switzerland)
Schlüsselwörter
  • Animals
  • Caenorhabditis elegans
  • Plants, Medicinal
  • Reactive Oxygen Species
  • Caenorhabditis elegans Proteins
  • Antidepressive Agents
  • Plant Extracts
  • Antioxidants
  • Oxidative Stress
  • Aging
  • Longevity
  • Heat-Shock Response
  • Mutation
  • Osmotic Pressure
  • Gene Knockout Techniques
Sprache
eng
Medium
Electronic
Online publication date
2021
Open access status
Open Access
Paginierung
1827
Datum der Veröffentlichung
2021
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2021
Titel
Increased Stress Resistance and Lifespan in <i>Chaenorhabditis elegans</i> Wildtype and Knockout Mutants-Implications for Depression Treatment by Medicinal Herbs.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
26

Files

https://www.mdpi.com/1420-3049/26/7/1827/pdf?version=1616740978 https://europepmc.org/articles/PMC8036369?pdf=render

Data source: Europe PubMed Central

Abstract
Depression and anxiety disorders are widespread diseases, and they belong to the leading causes of disability and greatest burdens on healthcare systems worldwide. It is expected that the numbers will dramatically rise during the COVID-19 pandemic. Established medications are not sufficient to adequately treat depression and are not available for everyone. Plants from traditional medicine may be promising alternatives to treat depressive symptoms. The model organism Chaenorhabditis elegans was used to assess the stress reducing effects of methanol/dichlormethane extracts from plants used in traditional medicine. After initial screening for antioxidant activity, nine extracts were selected for in vivo testing in oxidative stress, heat stress, and osmotic stress assays. Additionally, anti-aging properties were evaluated in lifespan assay. The extracts from Acanthopanax senticosus, Campsis grandiflora, Centella asiatica, Corydalis yanhusuo, Dan Zhi, Houttuynia cordata, Psoralea corylifolia, Valeriana officinalis, and Withaniasomnifera showed antioxidant activity of more than 15 Trolox equivalents per mg extract. The extracts significantly lowered ROS in mutants, increased resistance to heat stress and osmotic stress, and the extended lifespan of the nematodes. The plant extracts tested showed promising results in increasing stress resistance in the nematode model. Further analyses are needed, in order to unravel underlying mechanisms and transfer results to humans.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33805024
DOI
10.3390/molecules26071827
eISSN
1420-3049
Externe Identifier
  • PubMed Central ID: PMC8036369
Ausgabe der Veröffentlichung
7
Zeitschrift
Molecules
Schlüsselwörter
  • C. elegans
  • ageing
  • depression
  • phytochemical
  • phytotherapy
  • stress
  • Aging
  • Animals
  • Antidepressive Agents
  • Antioxidants
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Gene Knockout Techniques
  • Heat-Shock Response
  • Longevity
  • Mutation
  • Osmotic Pressure
  • Oxidative Stress
  • Plant Extracts
  • Plants, Medicinal
  • Reactive Oxygen Species
Sprache
eng
Country
Switzerland
PII
molecules26071827
Datum der Veröffentlichung
2021
Status
Published online
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Increased Stress Resistance and Lifespan in Chaenorhabditis elegans Wildtype and Knockout Mutants-Implications for Depression Treatment by Medicinal Herbs.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
26

Data source: PubMed

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