Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000685219400002&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153594
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: UA5RO
  • PubMed Identifier: 34144869
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • L-THP
  • Opioid use disorders (OUDs)
  • Pain
  • Addiction
  • Natural products
  • Neuro-circuitries
Artikelnummer
ARTN 153594
Datum der Veröffentlichung
2021
Status
Published
Titel
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders
Sub types
  • Review
Ausgabe der Zeitschrift
90

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2021.153594
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153594
Paginierung
153594 - 153594
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153594
Datum der Datenerfassung
2023
Titel
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders
Ausgabe der Zeitschrift
90

Data source: Crossref

Abstract
<h4>Background</h4>Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive potential and the lack of other effective alternatives to treat severe acute and chronic pains, opioids remain a serious public health issue. While, opioids directly influence the drug-seeking behavior, tolerance and withdrawal processes, through neuroadaptation, the brain's endogenous opioid system also adapts in the presence of chronic pain and could contribute to the difficulty of treatment. Despite the seemingly obvious interaction between the presence of pain and opioid-abuse, little is known about the underlying mechanisms in the brain.<h4>Purpose</h4>To review the current understanding of the interaction mechanisms of neurotransmitter circuitries in pain modulation and reward in the brain and the effects of L-tetrahydropalmatine (L-THP) and its metabolites in pain management and opioid use disorder and gain a better insight on the pharmacological profile and in vivo effects of L-THP and its metabolites.<h4>Method</h4>A detailed literature search on available (preclinical and clinical) studies about the effects of L-THP and its metabolites against drug addiction and chronic pain has been performed. The data was collected using various search engines such as PubMed, ScienceDirect, Google scholar and articles in English up to December 2020 were included in this review.<h4>Results</h4>L-THP and its metabolites demonstrated analgesic and anti-addiction effects. Due to their dual pharmacological properties (D1 partial agonist and D2 antagonist) these compounds could be used as molecular tools to provide a better understanding of the interactions between pain and addiction.<h4>Conclusion</h4>The available data confirms the potential of L-THP and its metabolites to treat both chronic pain and drug addiction. However, further clinical trials are needed to establish safety and efficacy.
Addresses
  • Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Autoren
DOI
10.1016/j.phymed.2021.153594
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 34144869
Funding acknowledgements
  • Deutsche Forschungsgemeinschaft: GRK2015/2
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Opioid-Related Disorders
  • Berberine Alkaloids
  • Analgesics, Opioid
  • Quality of Life
  • Chronic Pain
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153594
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
90

Data source: Europe PubMed Central

Abstract
BACKGROUND: Opioids have been prescribed to reduce suffering from pain and to enhance quality of life. Due to the addictive potential and the lack of other effective alternatives to treat severe acute and chronic pains, opioids remain a serious public health issue. While, opioids directly influence the drug-seeking behavior, tolerance and withdrawal processes, through neuroadaptation, the brain's endogenous opioid system also adapts in the presence of chronic pain and could contribute to the difficulty of treatment. Despite the seemingly obvious interaction between the presence of pain and opioid-abuse, little is known about the underlying mechanisms in the brain. PURPOSE: To review the current understanding of the interaction mechanisms of neurotransmitter circuitries in pain modulation and reward in the brain and the effects of L-tetrahydropalmatine (L-THP) and its metabolites in pain management and opioid use disorder and gain a better insight on the pharmacological profile and in vivo effects of L-THP and its metabolites. METHOD: A detailed literature search on available (preclinical and clinical) studies about the effects of L-THP and its metabolites against drug addiction and chronic pain has been performed. The data was collected using various search engines such as PubMed, ScienceDirect, Google scholar and articles in English up to December 2020 were included in this review. RESULTS: L-THP and its metabolites demonstrated analgesic and anti-addiction effects. Due to their dual pharmacological properties (D1 partial agonist and D2 antagonist) these compounds could be used as molecular tools to provide a better understanding of the interactions between pain and addiction. CONCLUSION: The available data confirms the potential of L-THP and its metabolites to treat both chronic pain and drug addiction. However, further clinical trials are needed to establish safety and efficacy.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34144869
DOI
10.1016/j.phymed.2021.153594
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Addiction
  • L-THP
  • Natural products
  • Neuro-circuitries
  • Opioid use disorders (OUDs)
  • Pain
  • Analgesics, Opioid
  • Berberine Alkaloids
  • Chronic Pain
  • Humans
  • Opioid-Related Disorders
  • Quality of Life
Sprache
eng
Country
Germany
Paginierung
153594
PII
S0944-7113(21)00136-7
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Role of Levo-tetrahydropalmatine and its metabolites for management of chronic pain and opioid use disorders.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
90

Data source: PubMed

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