Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

Publication type:
Journal article
Metadata:
Autoren
  • Pulok K Mukherjee
  • Thomas Efferth
  • Bhaskar Das
  • Amit Kar
  • Suparna Ghosh
  • Seha Singha
  • Pradip Debnath
  • Nanaocha Sharma
  • Pardeep Kumar Bhardwaj
  • Pallab Kanti Haldar
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000794997500005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2022.153930
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 1F2IY
  • PubMed Identifier: 35114450
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • SARS-CoV-2
  • COVID-19
  • Traditional system of medicine
  • Inflammatory cytokines
  • Immunomodulation
  • Phytochemicals
Artikelnummer
ARTN 153930
Datum der Veröffentlichung
2022
Status
Published
Titel
Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications
Sub types
  • Article
Ausgabe der Zeitschrift
98

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Pulok K Mukherjee
  • Thomas Efferth
  • Bhaskar Das
  • Amit Kar
  • Suparna Ghosh
  • Seha Singha
  • Pradip Debnath
  • Nanaocha Sharma
  • Pardeep Kumar Bhardwaj
  • Pallab Kanti Haldar
DOI
10.1016/j.phymed.2022.153930
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153930
Paginierung
153930 - 153930
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2022.153930
Datum der Datenerfassung
2023
Titel
Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications
Ausgabe der Zeitschrift
98

Data source: Crossref

Abstract
<h4>Background</h4>The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection.<h4>Purpose</h4>The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states.<h4>Study design</h4>Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications.<h4>Methods</h4>A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications.<h4>Results</h4>Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19.<h4>Conclusion</h4>Keeping in mind that the natural alternatives are in the priority for the management and prevention of the COVID-19, the present review may help to develop an alternative approach for the management of COVID-19 viral infection and post-COVID complications from a mechanistic point of view.
Addresses
  • Institute of Bioresources and Sustainable Development, Imphal-795001, India; School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700 032, India. Electronic address: naturalproductm@gmail.com.
Autoren
  • Pulok K Mukherjee
  • Thomas Efferth
  • Bhaskar Das
  • Amit Kar
  • Suparna Ghosh
  • Seha Singha
  • Pradip Debnath
  • Nanaocha Sharma
  • Pardeep Kumar Bhardwaj
  • Pallab Kanti Haldar
DOI
10.1016/j.phymed.2022.153930
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35114450
  • PubMed Central ID: PMC8730822
Funding acknowledgements
  • Department of Biotechnology:
Open access
true
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Sprache
eng
Medium
Print-Electronic
Online publication date
2022
Open access status
Open Access
Paginierung
153930
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications.
Sub types
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
98

Files

https://europepmc.org/articles/PMC8730822?pdf=render

Data source: Europe PubMed Central

Abstract
BACKGROUND: The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. PURPOSE: The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. STUDY DESIGN: Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. METHODS: A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. RESULTS: Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. CONCLUSION: Keeping in mind that the natural alternatives are in the priority for the management and prevention of the COVID-19, the present review may help to develop an alternative approach for the management of COVID-19 viral infection and post-COVID complications from a mechanistic point of view.
Date of acceptance
2022
Autoren
  • Pulok K Mukherjee
  • Thomas Efferth
  • Bhaskar Das
  • Amit Kar
  • Suparna Ghosh
  • Seha Singha
  • Pradip Debnath
  • Nanaocha Sharma
  • Pardeep Kumar Bhardwaj
  • Pallab Kanti Haldar
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35114450
DOI
10.1016/j.phymed.2022.153930
eISSN
1618-095X
Externe Identifier
  • PubMed Central ID: PMC8730822
Zeitschrift
Phytomedicine
Schlüsselwörter
  • COVID-19
  • Immunomodulation
  • Inflammatory cytokines
  • Phytochemicals
  • SARS-CoV-2
  • Traditional system of medicine
Sprache
eng
Country
Germany
Paginierung
153930
PII
S0944-7113(22)00008-3
Datum der Veröffentlichung
2022
Status
Published
Titel
Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
98

Data source: PubMed

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