The neuroprotective potential of carotenoids in vitro and in vivo

Publication type:
Journal article
Metadata:
Autoren
  • Janani Manochkumar
  • C George Priya Doss
  • Hesham R El-Seedi
  • Thomas Efferth
  • Siva Ramamoorthy
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000696238900026&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153676
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: UQ7KE
  • PubMed Identifier: 34339943
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Chemoprevention
  • Mitochondrial dysfunction
  • Natural products
  • Neurodegenerative diseases
  • Neuroinflammation
  • Neuroprotection
Artikelnummer
ARTN 153676
Datum der Veröffentlichung
2021
Status
Published
Titel
The neuroprotective potential of carotenoids <i>in vitro</i> and <i>in vivo</i>
Sub types
  • Article
Ausgabe der Zeitschrift
91

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Janani Manochkumar
  • C George Priya Doss
  • Hesham R El-Seedi
  • Thomas Efferth
  • Siva Ramamoorthy
DOI
10.1016/j.phymed.2021.153676
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153676
Paginierung
153676 - 153676
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153676
Datum der Datenerfassung
2024
Titel
The neuroprotective potential of carotenoids in vitro and in vivo
Ausgabe der Zeitschrift
91

Data source: Crossref

Abstract
<h4>Background</h4>Despite advances in research on neurodegenerative diseases, the pathogenesis and treatment response of neurodegenerative diseases remain unclear. Recent studies revealed a significant role of carotenoids to treat neurodegenerative diseases. The aim of this study was to systematically review the neuroprotective potential of carotenoids in vivo and in vitro and the molecular mechanisms and pathological factors contributing to major neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and stroke).<h4>Hypothesis</h4>Carotenoids as therapeutic molecules to target neurodegenerative diseases.<h4>Results</h4>Aggregation of toxic proteins, mitochondrial dysfunction, oxidative stress, the excitotoxic pathway, and neuroinflammation were the major pathological factors contributing to the progression of neurodegenerative diseases. Furthermore, in vitro and in vivo studies supported the beneficiary role of carotenoids, namely lycopene, β-carotene, crocin, crocetin, lutein, fucoxanthin and astaxanthin in alleviating disease progression. These carotenoids provide neuroprotection by inhibition of neuro-inflammation, microglial activation, excitotoxic pathway, modulation of autophagy, attenuation of oxidative damage and activation of defensive antioxidant enzymes. Additionally, studies conducted on humans also demonstrated that dietary intake of carotenoids lowers the risk of neurodegenerative diseases.<h4>Conclusion</h4>Carotenoids may be used as drugs to prevent and treat neurodegenerative diseases. Although, the in vitro and in vivo results are encouraging, further well conducted clinical studies on humans are required to conclude about the full potential of neurodegenerative diseases.
Addresses
  • School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
Autoren
  • Janani Manochkumar
  • C George Priya Doss
  • Hesham R El-Seedi
  • Thomas Efferth
  • Siva Ramamoorthy
DOI
10.1016/j.phymed.2021.153676
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 34339943
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Neurodegenerative Diseases
  • Carotenoids
  • Neuroprotective Agents
  • Antioxidants
  • Oxidative Stress
  • Neuroprotection
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153676
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
The neuroprotective potential of carotenoids in vitro and in vivo.
Sub types
  • Systematic Review
  • Journal Article
Ausgabe der Zeitschrift
91

Data source: Europe PubMed Central

Abstract
BACKGROUND: Despite advances in research on neurodegenerative diseases, the pathogenesis and treatment response of neurodegenerative diseases remain unclear. Recent studies revealed a significant role of carotenoids to treat neurodegenerative diseases. The aim of this study was to systematically review the neuroprotective potential of carotenoids in vivo and in vitro and the molecular mechanisms and pathological factors contributing to major neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and stroke). HYPOTHESIS: Carotenoids as therapeutic molecules to target neurodegenerative diseases. RESULTS: Aggregation of toxic proteins, mitochondrial dysfunction, oxidative stress, the excitotoxic pathway, and neuroinflammation were the major pathological factors contributing to the progression of neurodegenerative diseases. Furthermore, in vitro and in vivo studies supported the beneficiary role of carotenoids, namely lycopene, β-carotene, crocin, crocetin, lutein, fucoxanthin and astaxanthin in alleviating disease progression. These carotenoids provide neuroprotection by inhibition of neuro-inflammation, microglial activation, excitotoxic pathway, modulation of autophagy, attenuation of oxidative damage and activation of defensive antioxidant enzymes. Additionally, studies conducted on humans also demonstrated that dietary intake of carotenoids lowers the risk of neurodegenerative diseases. CONCLUSION: Carotenoids may be used as drugs to prevent and treat neurodegenerative diseases. Although, the in vitro and in vivo results are encouraging, further well conducted clinical studies on humans are required to conclude about the full potential of neurodegenerative diseases.
Date of acceptance
2021
Autoren
  • Janani Manochkumar
  • C George Priya Doss
  • Hesham R El-Seedi
  • Thomas Efferth
  • Siva Ramamoorthy
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34339943
DOI
10.1016/j.phymed.2021.153676
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Chemoprevention
  • Mitochondrial dysfunction
  • Natural products
  • Neurodegenerative diseases
  • Neuroinflammation
  • Neuroprotection
  • Antioxidants
  • Carotenoids
  • Humans
  • Neurodegenerative Diseases
  • Neuroprotection
  • Neuroprotective Agents
  • Oxidative Stress
Sprache
eng
Country
Germany
Paginierung
153676
PII
S0944-7113(21)00219-1
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
The neuroprotective potential of carotenoids in vitro and in vivo.
Sub types
  • Journal Article
  • Systematic Review
Ausgabe der Zeitschrift
91

Data source: PubMed

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