Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings
- Publication type:
- Journal article
- Metadata:
-
- Autoren
- Estefania Butassi
- Laura Svetaz
- Maria Cecilia Carpinella
- Thomas Efferth
- Susana Zacchino
- Autoren-URL
- https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000699653200001&DestLinkType=FullRecord&DestApp=WOS_CPL
- DOI
- 10.3390/antibiotics10091053
- Externe Identifier
- Clarivate Analytics Document Solution ID: UV7KV
- PubMed Identifier: 34572635
- ISSN
- 2079-6382
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- ANTIBIOTICS-BASEL
- Schlüsselwörter
- fungal biofilm
- antifungal resistance
- natural products
- Candida spp
- Fusarium spp
- Cryptococcus spp
- filamentous fungi
- mechanisms of antibiofilm action
- Artikelnummer
- ARTN 1053
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Titel
- Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings
- Sub types
- Review
- Ausgabe der Zeitschrift
- 10
Data source: Web of Science (Lite)
- Other metadata sources:
-
- Abstract
- <jats:p>The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty-seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health-care associated fungi, C. auris, as well as on other non-albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.</jats:p>
- Autoren
- Estefanía Butassi
- Laura Svetaz
- María Cecilia Carpinella
- Thomas Efferth
- Susana Zacchino
- DOI
- 10.3390/antibiotics10091053
- eISSN
- 2079-6382
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Antibiotics
- Sprache
- en
- Online publication date
- 2021
- Paginierung
- 1053 - 1053
- Status
- Published online
- Herausgeber
- MDPI AG
- Herausgeber URL
- http://dx.doi.org/10.3390/antibiotics10091053
- Datum der Datenerfassung
- 2021
- Titel
- Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings
- Ausgabe der Zeitschrift
- 10
Data source: Crossref
- Abstract
- The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017-May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty-seven manuscripts evaluated <i>Candida</i> spp. biofilms and two tested <i>Fusarium</i> and <i>Cryptococcus</i> spp. Only one manuscript involved <i>Aspergillus fumigatus</i>. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health-care associated fungi, <i>C. auris</i>, as well as on other non-<i>albicans Candida</i> spp., <i>Cryptococcus</i> sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
- Addresses
- Pharmacognosy Area, School of Biochemical and Pharmaceutical Sciences, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina.
- Autoren
- Estefanía Butassi
- Laura Svetaz
- María Cecilia Carpinella
- Thomas Efferth
- Susana Zacchino
- DOI
- 10.3390/antibiotics10091053
- eISSN
- 2079-6382
- Externe Identifier
- PubMed Identifier: 34572635
- PubMed Central ID: PMC8471798
- Funding acknowledgements
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2017-1381
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2018-02034
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2019-00721
- Open access
- true
- ISSN
- 2079-6382
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Antibiotics (Basel, Switzerland)
- Sprache
- eng
- Medium
- Electronic
- Online publication date
- 2021
- Open access status
- Open Access
- Paginierung
- 1053
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Publisher licence
- CC BY
- Datum der Datenerfassung
- 2021
- Titel
- Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings.
- Sub types
- review-article
- Review
- Journal Article
- Ausgabe der Zeitschrift
- 10
Files
https://www.mdpi.com/2079-6382/10/9/1053/pdf https://europepmc.org/articles/PMC8471798?pdf=render
Data source: Europe PubMed Central
- Abstract
- The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017-May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with the antibiofilm effect of pure natural compounds, with 10 of them including studies of the mechanism of action and five dealing with natural compounds included in nanosystems. Thirty-seven manuscripts evaluated Candida spp. biofilms and two tested Fusarium and Cryptococcus spp. Only one manuscript involved Aspergillus fumigatus. From the data presented here, it is clear that the search of natural products with activity against fungal biofilms has been a highly active area of research in recent years. However, it also reveals the necessity of deepening the studies by (i) evaluating the effect of natural products on biofilms formed by the newly emerged and worrisome health-care associated fungi, C. auris, as well as on other non-albicans Candida spp., Cryptococcus sp. and filamentous fungi; (ii) elucidating the mechanisms of action of the most active natural products; (iii) increasing the in vivo testing.
- Date of acceptance
- 2021
- Autoren
- Estefanía Butassi
- Laura Svetaz
- María Cecilia Carpinella
- Thomas Efferth
- Susana Zacchino
- Autoren-URL
- https://www.ncbi.nlm.nih.gov/pubmed/34572635
- DOI
- 10.3390/antibiotics10091053
- Externe Identifier
- PubMed Central ID: PMC8471798
- Funding acknowledgements
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2017-1381
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2018-02034
- Agencia Nacional de Promoción Científica y Tecnológica: PICT 2019-00721
- ISSN
- 2079-6382
- Ausgabe der Veröffentlichung
- 9
- Zeitschrift
- Antibiotics (Basel)
- Schlüsselwörter
- Candida spp.
- Cryptococcus spp.
- Fusarium spp.
- antifungal resistance
- filamentous fungi
- fungal biofilm
- mechanisms of antibiofilm action
- natural products
- Sprache
- eng
- Country
- Switzerland
- PII
- antibiotics10091053
- Datum der Veröffentlichung
- 2021
- Status
- Published online
- Titel
- Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi-Latest Findings.
- Sub types
- Journal Article
- Review
- Ausgabe der Zeitschrift
- 10
Data source: PubMed
- Beziehungen:
-