Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Publication type:
Journal article
Metadata:
Autoren
  • Srimanta Patra
  • Biswajita Pradhan
  • Rabindra Nayak
  • Chhandashree Behera
  • Surajit Das
  • Samir Kumar Patra
  • Thomas Efferth
  • Mrutyunjay Jena
  • Sujit Kumar Bhutia
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000685219400001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153554
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: UA5RO
  • PubMed Identifier: 34371479
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Apoptosis
  • Autophagy
  • Cancer
  • Chemoprevention
  • Polyphenol
Artikelnummer
ARTN 153554
Datum der Veröffentlichung
2021
Status
Published
Titel
Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action
Sub types
  • Review
Ausgabe der Zeitschrift
90

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Srimanta Patra
  • Biswajita Pradhan
  • Rabindra Nayak
  • Chhandashree Behera
  • Surajit Das
  • Samir Kumar Patra
  • Thomas Efferth
  • Mrutyunjay Jena
  • Sujit Kumar Bhutia
DOI
10.1016/j.phymed.2021.153554
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153554
Paginierung
153554 - 153554
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153554
Datum der Datenerfassung
2023
Titel
Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action
Ausgabe der Zeitschrift
90

Data source: Crossref

Abstract
<h4>Background</h4>Epidemiological studies has revealed that a diet rich in fruits and vegetables could lower the risk of certain cancers. In this setting, natural polyphenols are potent anticancer bioactive compounds to overcome the non-target specificity, undesirable cytotoxicity and high cost of treatment cancer chemotherapy.<h4>Purpose</h4>The review focuses on diverse classifications of the chemical diversity of dietary polyphenol and their molecular targets, modes of action, as well as preclinical and clinical applications in cancer prevention.<h4>Results</h4>The dietary polyphenols exhibit chemo-preventive activity through modulation of apoptosis, autophagy, cell cycle progression, inflammation, invasion and metastasis. Polyphenols possess strong antioxidant activity and control multiple molecular events through activation of tumor suppressor genes and inhibition of oncogenes involved in carcinogenesis. Numerous in vitro and in vivo studies have evidenced that these dietary phytochemicals regulate critical molecular targets and pathways to limit cancer initiation and progression. Moreover, natural polyphenols act synergistically with existing clinically approved drugs. The improved anticancer activity of combinations of polyphenols and anticancer drugs represents a promising perspective for clinical applications against many human cancers.<h4>Conclusion</h4>The anticancer properties exhibited by dietary polyphenols are mainly attributed to their anti-metastatic, anti-proliferative, anti-angiogenic, anti-inflammatory, cell cycle arrest, apoptotic and autophagic effects. Hence, regular consumption of dietary polyphenols as food or food additives or adjuvants can be a promising tactic to preclude adjournment or cancer therapy.
Addresses
  • Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, 769008, Odisha, India.
Autoren
  • Srimanta Patra
  • Biswajita Pradhan
  • Rabindra Nayak
  • Chhandashree Behera
  • Surajit Das
  • Samir Kumar Patra
  • Thomas Efferth
  • Mrutyunjay Jena
  • Sujit Kumar Bhutia
DOI
10.1016/j.phymed.2021.153554
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 34371479
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Neoplasms
  • Antineoplastic Agents
  • Chemoprevention
  • Diet
  • Polyphenols
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153554
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
90

Data source: Europe PubMed Central

Abstract
BACKGROUND: Epidemiological studies has revealed that a diet rich in fruits and vegetables could lower the risk of certain cancers. In this setting, natural polyphenols are potent anticancer bioactive compounds to overcome the non-target specificity, undesirable cytotoxicity and high cost of treatment cancer chemotherapy. PURPOSE: The review focuses on diverse classifications of the chemical diversity of dietary polyphenol and their molecular targets, modes of action, as well as preclinical and clinical applications in cancer prevention. RESULTS: The dietary polyphenols exhibit chemo-preventive activity through modulation of apoptosis, autophagy, cell cycle progression, inflammation, invasion and metastasis. Polyphenols possess strong antioxidant activity and control multiple molecular events through activation of tumor suppressor genes and inhibition of oncogenes involved in carcinogenesis. Numerous in vitro and in vivo studies have evidenced that these dietary phytochemicals regulate critical molecular targets and pathways to limit cancer initiation and progression. Moreover, natural polyphenols act synergistically with existing clinically approved drugs. The improved anticancer activity of combinations of polyphenols and anticancer drugs represents a promising perspective for clinical applications against many human cancers. CONCLUSION: The anticancer properties exhibited by dietary polyphenols are mainly attributed to their anti-metastatic, anti-proliferative, anti-angiogenic, anti-inflammatory, cell cycle arrest, apoptotic and autophagic effects. Hence, regular consumption of dietary polyphenols as food or food additives or adjuvants can be a promising tactic to preclude adjournment or cancer therapy.
Date of acceptance
2021
Autoren
  • Srimanta Patra
  • Biswajita Pradhan
  • Rabindra Nayak
  • Chhandashree Behera
  • Surajit Das
  • Samir Kumar Patra
  • Thomas Efferth
  • Mrutyunjay Jena
  • Sujit Kumar Bhutia
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34371479
DOI
10.1016/j.phymed.2021.153554
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Apoptosis
  • Autophagy
  • Cancer
  • Chemoprevention
  • Polyphenol
  • Antineoplastic Agents
  • Chemoprevention
  • Diet
  • Humans
  • Neoplasms
  • Polyphenols
Sprache
eng
Country
Germany
Paginierung
153554
PII
S0944-7113(21)00096-9
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
90

Data source: PubMed

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