Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells

Publication type:
Journal article
Metadata:
Autoren
  • Carla Di Chio
  • Min Zhou
  • Thomas Efferth
  • Tanja Schirmeister
  • Maria Zappala
  • Roberta Ettari
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000736084700001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1002/cbdv.202100451
eISSN
1612-1880
Externe Identifier
  • Clarivate Analytics Document Solution ID: ZB2JI
  • PubMed Identifier: 34871465
ISSN
1612-1872
Ausgabe der Veröffentlichung
2
Zeitschrift
CHEMISTRY & BIODIVERSITY
Schlüsselwörter
  • diarypentanoids
  • curcumin analogs
  • leukemia cells
  • cytotoxicity
  • synthesis
Artikelnummer
ARTN e202100451
Datum der Veröffentlichung
2022
Status
Published
Titel
Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells
Sub types
  • Article
Ausgabe der Zeitschrift
19

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:title>Abstract</jats:title><jats:p>This article described the synthesis and biological investigation of a series of symmetric diarylpentanoids, characterized by a dienone moiety and by a different pattern of substitution on the two phenyl rings. The series of compounds <jats:bold>1a</jats:bold>–<jats:bold>p</jats:bold> were tested against drug‐sensitive CCRF‐CEM and multidrug‐resistant CEM/ADR5000 cells to evaluate their cytotoxic profile, and all the diarypentanoids revealed to be active against both the leukemia cell lines, with the best activity shown by compound <jats:bold>1o</jats:bold> that showed a submicromolar activity against both CCRF‐CEM and CEM/ADR5000 cell lines (EC<jats:sub>50</jats:sub>=0.54 and 0.25 μM, respectively).</jats:p>
Autoren
  • Carla Di Chio
  • Min Zhou
  • Thomas Efferth
  • Tanja Schirmeister
  • Maria Zappalà
  • Roberta Ettari
DOI
10.1002/cbdv.202100451
eISSN
1612-1880
ISSN
1612-1872
Ausgabe der Veröffentlichung
2
Zeitschrift
Chemistry &amp; Biodiversity
Sprache
en
Online publication date
2021
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Wiley
Herausgeber URL
http://dx.doi.org/10.1002/cbdv.202100451
Datum der Datenerfassung
2023
Titel
Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF‐CEM and Multidrug‐Resistant CEM/ADR5000 Leukemia Cells
Ausgabe der Zeitschrift
19

Data source: Crossref

Abstract
This article described the synthesis and biological investigation of a series of symmetric diarylpentanoids, characterized by a dienone moiety and by a different pattern of substitution on the two phenyl rings. The series of compounds 1a-p were tested against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells to evaluate their cytotoxic profile, and all the diarypentanoids revealed to be active against both the leukemia cell lines, with the best activity shown by compound 1o that showed a submicromolar activity against both CCRF-CEM and CEM/ADR5000 cell lines (EC<sub>50</sub> =0.54 and 0.25 μM, respectively).
Addresses
  • Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Polo Annunziata, Viale SS. Annunziata, 98168, Messina, Italy.
Autoren
  • Carla Di Chio
  • Min Zhou
  • Thomas Efferth
  • Tanja Schirmeister
  • Maria Zappalà
  • Roberta Ettari
DOI
10.1002/cbdv.202100451
eISSN
1612-1880
Externe Identifier
  • PubMed Identifier: 34871465
Funding acknowledgements
  • FFABR 2020 UNIME:
Open access
false
ISSN
1612-1872
Ausgabe der Veröffentlichung
2
Zeitschrift
Chemistry & biodiversity
Schlüsselwörter
  • Cell Line, Tumor
  • Humans
  • Leukemia
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
e202100451
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2021
Titel
Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Data source: Europe PubMed Central

Abstract
This article described the synthesis and biological investigation of a series of symmetric diarylpentanoids, characterized by a dienone moiety and by a different pattern of substitution on the two phenyl rings. The series of compounds 1a-p were tested against drug-sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 cells to evaluate their cytotoxic profile, and all the diarypentanoids revealed to be active against both the leukemia cell lines, with the best activity shown by compound 1o that showed a submicromolar activity against both CCRF-CEM and CEM/ADR5000 cell lines (EC50 =0.54 and 0.25 μM, respectively).
Date of acceptance
2021
Autoren
  • Carla Di Chio
  • Min Zhou
  • Thomas Efferth
  • Tanja Schirmeister
  • Maria Zappalà
  • Roberta Ettari
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34871465
DOI
10.1002/cbdv.202100451
eISSN
1612-1880
Funding acknowledgements
  • FFABR 2020 UNIME:
Ausgabe der Veröffentlichung
2
Zeitschrift
Chem Biodivers
Schlüsselwörter
  • curcumin analogs
  • cytotoxicity
  • diarypentanoids
  • leukemia cells
  • synthesis
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Cell Line, Tumor
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Humans
  • Leukemia
Sprache
eng
Country
Switzerland
Paginierung
e202100451
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Synthesis and Cytotoxicity of Diarylpentanoids against Sensitive CCRF-CEM and Multidrug-Resistant CEM/ADR5000 Leukemia Cells.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
19

Data source: PubMed

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