Cardioprotective effects of phytopigments via multiple signaling pathways

Publication type:
Journal article
Metadata:
Autoren
  • Ressin Varghese
  • C George Priya Doss
  • Raju Suresh Kumar
  • Abdulrahman I Almansour
  • Natarajan Arumugam
  • Thomas Efferth
  • Siva Ramamoorthy
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000726371000003&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153859
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: XI8RI
  • PubMed Identifier: 34856476
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Cardiovascular diseases
  • Carotenoids
  • Flavonoids
  • Natural products
  • Signaling transduction pathways
  • Xanthophylls
Artikelnummer
ARTN 153859
Datum der Veröffentlichung
2022
Status
Published
Titel
Cardioprotective effects of phytopigments via multiple signaling pathways
Sub types
  • Article
Ausgabe der Zeitschrift
95

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Ressin Varghese
  • C George Priya Doss
  • Raju Suresh Kumar
  • Abdulrahman I Almansour
  • Natarajan Arumugam
  • Thomas Efferth
  • Siva Ramamoorthy
DOI
10.1016/j.phymed.2021.153859
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153859
Paginierung
153859 - 153859
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153859
Datum der Datenerfassung
2023
Titel
Cardioprotective effects of phytopigments via multiple signaling pathways
Ausgabe der Zeitschrift
95

Data source: Crossref

Abstract
<h4>Background</h4>Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both in vitro and in vivo.<h4>Purpose</h4>This review gives an overview of the cardioprotective effects of phytopigments based on in vitro and in vivo studies as well as clinical trials.<h4>Methods</h4>A literature-based survey was performed to collect the available data on cardioprotective activities of phytopigments via electronic search engines such as PubMed, Google Scholar, and Scopus.<h4>Results</h4>Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-κB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-α, and RA.<h4>Conclusion</h4>Phytopigments represent promising candidates to develop novel and effective CVD therapeutics. More randomized, placebo-controlled clinical studies are recommended to establish the clinical efficacy of phytopigments.
Addresses
  • School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
Autoren
  • Ressin Varghese
  • C George Priya Doss
  • Raju Suresh Kumar
  • Abdulrahman I Almansour
  • Natarajan Arumugam
  • Thomas Efferth
  • Siva Ramamoorthy
DOI
10.1016/j.phymed.2021.153859
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 34856476
Funding acknowledgements
  • King Saud University:
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Animals
  • Humans
  • Carotenoids
  • Xanthophylls
  • Anthraquinones
  • Flavonoids
  • Anthocyanins
  • NF-kappa B
  • Cardiotonic Agents
  • Antioxidants
  • Signal Transduction
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153859
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2021
Titel
Cardioprotective effects of phytopigments via multiple signaling pathways.
Sub types
  • Review
  • Journal Article
Ausgabe der Zeitschrift
95

Data source: Europe PubMed Central

Abstract
BACKGROUND: Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both in vitro and in vivo. PURPOSE: This review gives an overview of the cardioprotective effects of phytopigments based on in vitro and in vivo studies as well as clinical trials. METHODS: A literature-based survey was performed to collect the available data on cardioprotective activities of phytopigments via electronic search engines such as PubMed, Google Scholar, and Scopus. RESULTS: Different classes of phytopigments such as carotenoids, xanthophylls, flavonoids, anthocyanins, anthraquinones alleviate major CVDs (e.g., cardiac hypertrophy, atherosclerosis, hypertension, cardiotoxicities) via acting on signaling pathways related to AMPK, NF-κB, NRF2, PPARs, AKT, TLRs, MAPK, JAK/STAT, NLRP3, TNF-α, and RA. CONCLUSION: Phytopigments represent promising candidates to develop novel and effective CVD therapeutics. More randomized, placebo-controlled clinical studies are recommended to establish the clinical efficacy of phytopigments.
Date of acceptance
2021
Autoren
  • Ressin Varghese
  • C George Priya Doss
  • Raju Suresh Kumar
  • Abdulrahman I Almansour
  • Natarajan Arumugam
  • Thomas Efferth
  • Siva Ramamoorthy
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34856476
DOI
10.1016/j.phymed.2021.153859
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Cardiovascular diseases
  • Carotenoids
  • Flavonoids
  • Natural products
  • Signaling transduction pathways
  • Xanthophylls
  • Animals
  • Anthocyanins
  • Anthraquinones
  • Antioxidants
  • Cardiotonic Agents
  • Carotenoids
  • Flavonoids
  • Humans
  • NF-kappa B
  • Signal Transduction
  • Xanthophylls
Sprache
eng
Country
Germany
Paginierung
153859
PII
S0944-7113(21)00400-1
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Cardioprotective effects of phytopigments via multiple signaling pathways.
Sub types
  • Journal Article
  • Review
Ausgabe der Zeitschrift
95

Data source: PubMed

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