Dendrobium officinale Polysaccharide Alleviates Intestinal Inflammation by Promoting Small Extracellular Vesicle Packaging of miR-433-3p

Publication type:
Journal article
Metadata:
Autoren
  • Huifan Liu
  • Jiaxi Liang
  • Yuming Zhong
  • Gengsheng Xiao
  • Thomas Efferth
  • Milen I Georgiev
  • Celia Vargas-De-la-Cruz
  • Vivek K Bajpai
  • Giovanni Caprioli
  • Jianliang Liu
  • Jintian Lin
  • Hui Wu
  • Lianxin Peng
  • Yongjun Li
  • Lukai Ma
  • Jianbo Xiao
  • Qin Wang
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000727379700006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1021/acs.jafc.1c05134
eISSN
1520-5118
Externe Identifier
  • Clarivate Analytics Document Solution ID: XK3OR
  • PubMed Identifier: 34739249
ISSN
0021-8561
Ausgabe der Veröffentlichung
45
Zeitschrift
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Schlüsselwörter
  • Dendrobium officinale polysaccharide
  • inflammatory bowel disease
  • intestinal small extracellular vesicles
  • miR-433-3p
Paginierung
13510 - 13523
Datum der Veröffentlichung
2021
Status
Published
Titel
<i>Dendrobium officinale</i> Polysaccharide Alleviates Intestinal Inflammation by Promoting Small Extracellular Vesicle Packaging of miR-433-3p
Sub types
  • Article
Ausgabe der Zeitschrift
69

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Huifan Liu
  • Jiaxi Liang
  • Yuming Zhong
  • Gengsheng Xiao
  • Thomas Efferth
  • Milen I Georgiev
  • Celia Vargas-De-La-Cruz
  • Vivek K Bajpai
  • Giovanni Caprioli
  • Jianliang Liu
  • Jintian Lin
  • Hui Wu
  • Lianxin Peng
  • Yongjun Li
  • Lukai Ma
  • Jianbo Xiao
  • Qin Wang
DOI
10.1021/acs.jafc.1c05134
eISSN
1520-5118
ISSN
0021-8561
Ausgabe der Veröffentlichung
45
Zeitschrift
Journal of Agricultural and Food Chemistry
Sprache
en
Online publication date
2021
Paginierung
13510 - 13523
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
American Chemical Society (ACS)
Herausgeber URL
http://dx.doi.org/10.1021/acs.jafc.1c05134
Datum der Datenerfassung
2023
Titel
<i>Dendrobium officinale</i> Polysaccharide Alleviates Intestinal Inflammation by Promoting Small Extracellular Vesicle Packaging of miR-433-3p
Ausgabe der Zeitschrift
69

Data source: Crossref

Abstract
<i>Dendrobium officinale</i> polysaccharide (DOP) attenuates inflammatory bowel disease (IBD), but its role in regulating cross-talk between intestinal epithelial cells (IEC) and macrophages against IBD is unclear. This study aimed to investigate DOP protective effects on the intestinal inflammatory response through regulation by miRNA in small extracellular vesicles (sEVs). Our results show that DOP interfered with the secretion of small extracellular vesicles (DIEs) by IEC, which reduced the levels of inflammatory mediators. Increased miR-433-3p expression in DIEs was identified as an important protector against intestinal inflammation. DOP regulated the loading of miR-433-3p by hnRNPA2B1 into the intestinal sEV to increase the abundance of miR-433-3p. DIEs delivered miR-433-3p to lipopolysaccharide-induced macrophages and targeted the MAPK8 gene, leading to inhibition of the MAPK signaling pathway and reduced production of inflammatory cytokines. One protective mechanism of DOP is mediated by intestinal sEV containing miR-433-3p, which is a potential therapeutic agent for the prevention of inflammatory factor accumulation from excessive intestinal macrophage activity and for restoring homeostasis in the intestinal microenvironment.
Addresses
  • Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Guangzhou City, Guangdong 510642, China.
Autoren
  • Huifan Liu
  • Jiaxi Liang
  • Yuming Zhong
  • Gengsheng Xiao
  • Thomas Efferth
  • Milen I Georgiev
  • Celia Vargas-De-La-Cruz
  • Vivek K Bajpai
  • Giovanni Caprioli
  • Jianliang Liu
  • Jintian Lin
  • Hui Wu
  • Lianxin Peng
  • Yongjun Li
  • Lukai Ma
  • Jianbo Xiao
  • Qin Wang
DOI
10.1021/acs.jafc.1c05134
eISSN
1520-5118
Externe Identifier
  • PubMed Identifier: 34739249
Funding acknowledgements
  • The Key Fundamental and Applied Basic Research Fund??of Jiangmen City.:
  • Science and Technology Commissioner Project of Guangzhou: GZKTP201937
  • Fundamental and Applied Basic Research Fund for Young Scholars of Guangdong Province: 2019A1515110823
  • National Natural Science Fund of China: 32001622
  • Guangdong University Youth Innovation Talent Project: KA2001957
  • National Key Research and Development Program of China: 2018YFC1602101, 2018YFD0901003
  • Science and Technology Project of Heyuan: 2019003
  • the Fundamental and Applied Basic Research Fund for Science and Technology Planning Project: 202002030383
Open access
false
ISSN
0021-8561
Ausgabe der Veröffentlichung
45
Zeitschrift
Journal of agricultural and food chemistry
Schlüsselwörter
  • Dendrobium
  • Inflammation
  • Polysaccharides
  • MicroRNAs
  • Extracellular Vesicles
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
13510 - 13523
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
<i>Dendrobium officinale</i> Polysaccharide Alleviates Intestinal Inflammation by Promoting Small Extracellular Vesicle Packaging of miR-433-3p.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
69

Data source: Europe PubMed Central

Abstract
Dendrobium officinale polysaccharide (DOP) attenuates inflammatory bowel disease (IBD), but its role in regulating cross-talk between intestinal epithelial cells (IEC) and macrophages against IBD is unclear. This study aimed to investigate DOP protective effects on the intestinal inflammatory response through regulation by miRNA in small extracellular vesicles (sEVs). Our results show that DOP interfered with the secretion of small extracellular vesicles (DIEs) by IEC, which reduced the levels of inflammatory mediators. Increased miR-433-3p expression in DIEs was identified as an important protector against intestinal inflammation. DOP regulated the loading of miR-433-3p by hnRNPA2B1 into the intestinal sEV to increase the abundance of miR-433-3p. DIEs delivered miR-433-3p to lipopolysaccharide-induced macrophages and targeted the MAPK8 gene, leading to inhibition of the MAPK signaling pathway and reduced production of inflammatory cytokines. One protective mechanism of DOP is mediated by intestinal sEV containing miR-433-3p, which is a potential therapeutic agent for the prevention of inflammatory factor accumulation from excessive intestinal macrophage activity and for restoring homeostasis in the intestinal microenvironment.
Autoren
  • Huifan Liu
  • Jiaxi Liang
  • Yuming Zhong
  • Gengsheng Xiao
  • Thomas Efferth
  • Milen I Georgiev
  • Celia Vargas-De-La-Cruz
  • Vivek K Bajpai
  • Giovanni Caprioli
  • Jianliang Liu
  • Jintian Lin
  • Hui Wu
  • Lianxin Peng
  • Yongjun Li
  • Lukai Ma
  • Jianbo Xiao
  • Qin Wang
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34739249
DOI
10.1021/acs.jafc.1c05134
eISSN
1520-5118
Ausgabe der Veröffentlichung
45
Zeitschrift
J Agric Food Chem
Schlüsselwörter
  • Dendrobium officinale polysaccharide
  • inflammatory bowel disease
  • intestinal small extracellular vesicles
  • miR-433-3p
  • Dendrobium
  • Extracellular Vesicles
  • Inflammation
  • MicroRNAs
  • Polysaccharides
Sprache
eng
Country
United States
Paginierung
13510 - 13523
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Dendrobium officinale Polysaccharide Alleviates Intestinal Inflammation by Promoting Small Extracellular Vesicle Packaging of miR-433-3p.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
69

Data source: PubMed

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