Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000726377200005&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153830
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: XI8TS
  • PubMed Identifier: 34775359
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • CRISPR/Cas9
  • Genome editing
  • Phytochemicals
  • Nanotechnology
Artikelnummer
ARTN 153830
Datum der Veröffentlichung
2022
Status
Published
Titel
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy
Sub types
  • Article
Ausgabe der Zeitschrift
94

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.phymed.2021.153830
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153830
Paginierung
153830 - 153830
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153830
Datum der Datenerfassung
2023
Titel
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy
Ausgabe der Zeitschrift
94

Data source: Crossref

Abstract
<h4>Background</h4>With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies.<h4>Purpose</h4>We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemical targeting the CRISPR/Cas9 system.<h4>Results</h4>Genome engineering has been significantly accelerated by the advancement of the CRISPR/Cas9 technique. Phytochemicals play a key role in treating cancer by targeting various mechanisms and pathways.<h4>Conclusions</h4>The use of CRISPR/Cas9 for nanoscale delivery of phytochemicals opens new avenues in cancer therapy. One of the main obstacles in the clinical application of CRISPR/Cas9 is safe and efficient delivery. As viral delivery methods have certain drawbacks, there is an urgent need to develop non-viral delivery systems for therapeutic applications.
Addresses
  • College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Autoren
DOI
10.1016/j.phymed.2021.153830
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 34775359
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Neoplasms
  • Phytochemicals
  • CRISPR-Cas Systems
  • Gene Editing
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153830
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2021
Titel
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
94

Data source: Europe PubMed Central

Abstract
BACKGROUND: With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies. PURPOSE: We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemical targeting the CRISPR/Cas9 system. RESULTS: Genome engineering has been significantly accelerated by the advancement of the CRISPR/Cas9 technique. Phytochemicals play a key role in treating cancer by targeting various mechanisms and pathways. CONCLUSIONS: The use of CRISPR/Cas9 for nanoscale delivery of phytochemicals opens new avenues in cancer therapy. One of the main obstacles in the clinical application of CRISPR/Cas9 is safe and efficient delivery. As viral delivery methods have certain drawbacks, there is an urgent need to develop non-viral delivery systems for therapeutic applications.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34775359
DOI
10.1016/j.phymed.2021.153830
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • CRISPR/Cas9
  • Genome editing
  • Nanotechnology
  • Phytochemicals
  • CRISPR-Cas Systems
  • Gene Editing
  • Humans
  • Neoplasms
  • Phytochemicals
Sprache
eng
Country
Germany
Paginierung
153830
PII
S0944-7113(21)00371-8
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Nanoscale delivery of phytochemicals targeting CRISPR/Cas9 for cancer therapy.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
94

Data source: PubMed

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