Suppression of colorectal carcinogenesis by naringin

Publication type:
Journal article
Metadata:
Autoren
  • Bushra Ansari
  • Michael Aschner
  • Yaseen Hussain
  • Thomas Efferth
  • Haroon Khan
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000789705500004&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.phymed.2021.153897
eISSN
1618-095X
Externe Identifier
  • Clarivate Analytics Document Solution ID: 0X4VF
  • PubMed Identifier: 35026507
ISSN
0944-7113
Zeitschrift
PHYTOMEDICINE
Schlüsselwörter
  • Carcinogenesis
  • Chemoprevention
  • Colorectal cancer
  • Flavonoids
  • Naringin
Artikelnummer
ARTN 153897
Datum der Veröffentlichung
2022
Status
Published
Titel
Suppression of colorectal carcinogenesis by naringin
Sub types
  • Article
Ausgabe der Zeitschrift
96

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Bushra Ansari
  • Michael Aschner
  • Yaseen Hussain
  • Thomas Efferth
  • Haroon Khan
DOI
10.1016/j.phymed.2021.153897
ISSN
0944-7113
Zeitschrift
Phytomedicine
Sprache
en
Artikelnummer
153897
Paginierung
153897 - 153897
Datum der Veröffentlichung
2022
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.phymed.2021.153897
Datum der Datenerfassung
2023
Titel
Suppression of colorectal carcinogenesis by naringin
Ausgabe der Zeitschrift
96

Data source: Crossref

Abstract
<h4>Background</h4>Colorectal cancer is the third most malignant cancer worldwide. Despite novel treatment options, the incidence and mortality rates of colon cancer continue to increase in most countries, especially in US, European and Asian countries. Colorectal carcinogenesis is multifactorial, including dietary and genetic factors, as well as lacking physical activity. Vegetables and fruits contain high amounts of secondary metabolites, which might reduce the risk for colorectal carcinogenesis. Flavonoids are important bioactive polyphenolic compounds. There are more than 4,000 different flavonoids, including flavanones, flavonoids, isoflavonoids, flavones, and catechins in a large variety of plant.<h4>Hypothesis</h4>Among various other flavonoids, naringin in Citrus fruits has been a subject of intense scrutiny for its activity against many types of cancer, including colorectal cancer. We hypothesize that naringin is capable to inhibit the growth of transformed colonocytes and to induce programmed cell death in colon cancer cells.<h4>Results</h4>We comprehensively review the inhibitory effects of naringin on colorectal cancers and address the underlying mechanistic pathways such as NF-κB/IL-6/STAT3, PI3K/AKT/mTOR, apoptosis, NF-κB-COX-2-iNOS, and β-catenin pathways.<h4>Conclusion</h4>Naringin suppresses colorectal inflammation and carcinogenesis by various signaling pathways. Randomized clinical trials are needed to determine their effectiveness in combating colorectal cancer.
Addresses
  • Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.
Autoren
  • Bushra Ansari
  • Michael Aschner
  • Yaseen Hussain
  • Thomas Efferth
  • Haroon Khan
DOI
10.1016/j.phymed.2021.153897
eISSN
1618-095X
Externe Identifier
  • PubMed Identifier: 35026507
Open access
false
ISSN
0944-7113
Zeitschrift
Phytomedicine : international journal of phytotherapy and phytopharmacology
Schlüsselwörter
  • Humans
  • Colonic Neoplasms
  • Flavonoids
  • Flavanones
  • Phosphatidylinositol 3-Kinases
  • Carcinogenesis
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
153897
Datum der Veröffentlichung
2022
Status
Published
Datum der Datenerfassung
2022
Titel
Suppression of colorectal carcinogenesis by naringin.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
96

Data source: Europe PubMed Central

Abstract
BACKGROUND: Colorectal cancer is the third most malignant cancer worldwide. Despite novel treatment options, the incidence and mortality rates of colon cancer continue to increase in most countries, especially in US, European and Asian countries. Colorectal carcinogenesis is multifactorial, including dietary and genetic factors, as well as lacking physical activity. Vegetables and fruits contain high amounts of secondary metabolites, which might reduce the risk for colorectal carcinogenesis. Flavonoids are important bioactive polyphenolic compounds. There are more than 4,000 different flavonoids, including flavanones, flavonoids, isoflavonoids, flavones, and catechins in a large variety of plant. HYPOTHESIS: Among various other flavonoids, naringin in Citrus fruits has been a subject of intense scrutiny for its activity against many types of cancer, including colorectal cancer. We hypothesize that naringin is capable to inhibit the growth of transformed colonocytes and to induce programmed cell death in colon cancer cells. RESULTS: We comprehensively review the inhibitory effects of naringin on colorectal cancers and address the underlying mechanistic pathways such as NF-κB/IL-6/STAT3, PI3K/AKT/mTOR, apoptosis, NF-κB-COX-2-iNOS, and β-catenin pathways. CONCLUSION: Naringin suppresses colorectal inflammation and carcinogenesis by various signaling pathways. Randomized clinical trials are needed to determine their effectiveness in combating colorectal cancer.
Date of acceptance
2021
Autoren
  • Bushra Ansari
  • Michael Aschner
  • Yaseen Hussain
  • Thomas Efferth
  • Haroon Khan
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/35026507
DOI
10.1016/j.phymed.2021.153897
eISSN
1618-095X
Zeitschrift
Phytomedicine
Schlüsselwörter
  • Carcinogenesis
  • Chemoprevention
  • Colorectal cancer
  • Flavonoids
  • Naringin
  • Carcinogenesis
  • Colonic Neoplasms
  • Flavanones
  • Flavonoids
  • Humans
  • Phosphatidylinositol 3-Kinases
Sprache
eng
Country
Germany
Paginierung
153897
PII
S0944-7113(21)00437-2
Datum der Veröffentlichung
2022
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2022
Titel
Suppression of colorectal carcinogenesis by naringin.
Sub types
  • Journal Article
Ausgabe der Zeitschrift
96

Data source: PubMed

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