The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist-from fundamentals to future challenges

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000706790100009&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.freeradbiomed.2021.09.026
eISSN
1873-4596
Externe Identifier
  • Clarivate Analytics Document Solution ID: WG1XB
  • PubMed Identifier: 34610364
ISSN
0891-5849
Zeitschrift
FREE RADICAL BIOLOGY AND MEDICINE
Schlüsselwörter
  • Diet
  • Gut barrier
  • Microbiota
  • Metabolome
  • Metabolism
  • Inflammation
  • Intestine
  • Oxidative stress
  • Short-chain fatty acid
Paginierung
265 - 285
Datum der Veröffentlichung
2021
Status
Published
Titel
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist-from fundamentals to future challenges
Sub types
  • Review
Ausgabe der Zeitschrift
176

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.freeradbiomed.2021.09.026
ISSN
0891-5849
Zeitschrift
Free Radical Biology and Medicine
Sprache
en
Paginierung
265 - 285
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.freeradbiomed.2021.09.026
Datum der Datenerfassung
2023
Titel
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist – from fundamentals to future challenges
Ausgabe der Zeitschrift
176

Data source: Crossref

Abstract
The role of the intestine in human health and disease has historically been neglected and was mostly attributed to digestive and absorptive functions. In the past two decades, however, discoveries related to human nutrition and intestinal host-microbe reciprocal interaction have established the essential role of intestinal health in the pathogenesis of chronic diseases and the overall wellbeing. That transfer of gut microbiota could be a means of disease phenotype transfer has revolutionized our understanding of chronic disease pathogenesis. This narrative review highlights the major concepts related to intestinal microbiota, metabolism, and metabolome (3M) that have facilitated our fundamental understanding of the association between the intestine, and human health and disease. In line with increased interest of microbiota-dependent modulation of human health by dietary phytochemicals, we have also discussed the emerging concepts beyond the phytochemical bioactivities which emphasizes the integral role of microbial metabolites of parent phytochemicals at extraintestinal tissues. Finally, this review concludes with challenges and future prospects in defining the 3M interactions and has emphasized the fact that, it takes 'guts' to stay healthy.
Addresses
  • Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India. Electronic address: priyankar.dey@thapar.edu.
Autoren
DOI
10.1016/j.freeradbiomed.2021.09.026
eISSN
1873-4596
Externe Identifier
  • PubMed Identifier: 34610364
Funding acknowledgements
  • Thapar Institute of Engineering and Technology:
Open access
false
ISSN
0891-5849
Zeitschrift
Free radical biology & medicine
Schlüsselwörter
  • Intestines
  • Humans
  • Metabolome
  • Microbiota
  • Gastrointestinal Microbiome
  • Host Microbial Interactions
Sprache
eng
Medium
Print-Electronic
Online publication date
2021
Paginierung
265 - 285
Datum der Veröffentlichung
2021
Status
Published
Datum der Datenerfassung
2021
Titel
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist - from fundamentals to future challenges.
Sub types
  • Research Support, Non-U.S. Gov't
  • Review
  • Journal Article
Ausgabe der Zeitschrift
176

Data source: Europe PubMed Central

Abstract
The role of the intestine in human health and disease has historically been neglected and was mostly attributed to digestive and absorptive functions. In the past two decades, however, discoveries related to human nutrition and intestinal host-microbe reciprocal interaction have established the essential role of intestinal health in the pathogenesis of chronic diseases and the overall wellbeing. That transfer of gut microbiota could be a means of disease phenotype transfer has revolutionized our understanding of chronic disease pathogenesis. This narrative review highlights the major concepts related to intestinal microbiota, metabolism, and metabolome (3M) that have facilitated our fundamental understanding of the association between the intestine, and human health and disease. In line with increased interest of microbiota-dependent modulation of human health by dietary phytochemicals, we have also discussed the emerging concepts beyond the phytochemical bioactivities which emphasizes the integral role of microbial metabolites of parent phytochemicals at extraintestinal tissues. Finally, this review concludes with challenges and future prospects in defining the 3M interactions and has emphasized the fact that, it takes 'guts' to stay healthy.
Date of acceptance
2021
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/34610364
DOI
10.1016/j.freeradbiomed.2021.09.026
eISSN
1873-4596
Zeitschrift
Free Radic Biol Med
Schlüsselwörter
  • Diet
  • Gut barrier
  • Inflammation
  • Intestine
  • Metabolism
  • Metabolome
  • Microbiota
  • Oxidative stress
  • Short-chain fatty acid
  • Gastrointestinal Microbiome
  • Host Microbial Interactions
  • Humans
  • Intestines
  • Metabolome
  • Microbiota
Sprache
eng
Country
United States
Paginierung
265 - 285
PII
S0891-5849(21)00746-2
Datum der Veröffentlichung
2021
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist - from fundamentals to future challenges.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review
Ausgabe der Zeitschrift
176

Data source: PubMed

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