Activity of Cordycepin From Cordyceps sinensis Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000616543600001&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1177/1934578X21993350
eISSN
1555-9475
Externe Identifier
  • Clarivate Analytics Document Solution ID: QE9SP
ISSN
1934-578X
Ausgabe der Veröffentlichung
2
Zeitschrift
NATURAL PRODUCT COMMUNICATIONS
Schlüsselwörter
  • cordycepin
  • drug resistance
  • traditional medicine
  • transcriptomics
  • ABC transporters
Datum der Veröffentlichung
2021
Status
Published
Titel
Activity of Cordycepin From <i>Cordyceps sinensis</i> Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling
Sub types
  • Article
Ausgabe der Zeitschrift
16

Data source: Web of Science (Lite)

Other metadata sources:
Abstract
<jats:p> Cordycepin is one of the substantial components of the parasitic fungus Cordyceps sinensis as well as other Cordyceps species. It exerts various effects such as antimetastatic, antiinflammatory, antioxidant, and neuroprotective activities. Assorted studies revealed in vitro and in vivo anticancer influence of cordycepin and put forward its potential for cancer therapy. However, the role of multidrug resistance-associated mechanisms for the antitumor effect of cordycepin has not been investigated in great detail thus far. Therefore, we searched cordycepin’s cytotoxicity with regard to well-known anticancer drug resistance mechanisms, including ABCB1, ABCB5, ABCC1, ABCG2, EGFR, and TP53, and identified putative molecular determinants related to the cellular responsiveness of cordycepin. Bioinformatic analyses of NCI microarray data and gene promoter transcription factor binding motif analyses were performed to specify the mechanisms of cordycepin towards cancer cells. COMPARE and hierarchical analyses led to the detection of the genes involved in cordycepin’s cytotoxicity and sensitivity and resistance of cell lines towards cordycepin. Tumor-type dependent response and cross-resistance profiles were further unravelled. We found transcription factors potentially involved in the common transcriptional regulation of the genes identified by COMPARE analyses. Cordycepin bypassed resistance mediated by the expression of ATP-binding cassete (ABC) transporters (P-gp, ABCB5, ABCC1 and BCRP) and mutant epidermal growth factor receptor (EGFR). The drug sensitivity profiles of several DNA Topo I and II inhibitors were significantly correlated with those of cordycepin’s activity. Among eight different tumor types, prostate cancer was the most sensitive, whereas renal carcinoma was the most resistant to cordycepin. NF-κB was discovered as a common transcription factor. The potential of cordycepin is set forth as a potential new drug lead by bioinformatic evaluations. Further experimental studies are warranted for better understanding of cordycepin’s activity against cancer. </jats:p>
Autoren
DOI
10.1177/1934578x21993350
eISSN
1555-9475
ISSN
1934-578X
Ausgabe der Veröffentlichung
2
Zeitschrift
Natural Product Communications
Sprache
en
Online publication date
2021
Paginierung
1934578X2199335 - 1934578X2199335
Datum der Veröffentlichung
2021
Status
Published
Herausgeber
SAGE Publications
Herausgeber URL
http://dx.doi.org/10.1177/1934578x21993350
Datum der Datenerfassung
2021
Titel
Activity of Cordycepin From <i>Cordyceps sinensis</i> Against Drug-Resistant Tumor Cells as Determined by Gene Expression and Drug Sensitivity Profiling
Ausgabe der Zeitschrift
16

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