Altered neural responses to social fairness in bipolar disorder

Publication type:
Journal article
Metadata:
Autoren
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000600619100129&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.nicl.2020.102487
Externe Identifier
  • Clarivate Analytics Document Solution ID: PH7WY
  • PubMed Identifier: 33395978
ISSN
2213-1582
Zeitschrift
NEUROIMAGE-CLINICAL
Schlüsselwörter
  • Bipolar disorder
  • Social decision-making
  • Ultimatum game
  • Fairness
  • Ambiguity
Artikelnummer
ARTN 102487
Datum der Veröffentlichung
2020
Status
Published
Titel
Altered neural responses to social fairness in bipolar disorder
Sub types
  • Article
Ausgabe der Zeitschrift
28

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
DOI
10.1016/j.nicl.2020.102487
ISSN
2213-1582
Zeitschrift
NeuroImage: Clinical
Sprache
en
Artikelnummer
102487
Paginierung
102487 - 102487
Datum der Veröffentlichung
2020
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.nicl.2020.102487
Datum der Datenerfassung
2022
Titel
Altered neural responses to social fairness in bipolar disorder
Ausgabe der Zeitschrift
28

Data source: Crossref

Abstract
Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity.
Addresses
  • Department of Clinical Psychology and Neuropsychology, Institute of Psychology, Johannes Gutenberg-University Mainz, Germany; Department of Microeconomics and Public Economics, School of Business and Economics, Maastricht University, The Netherlands. Electronic address: i.lois@maastrichtuniversity.nl.
Autoren
DOI
10.1016/j.nicl.2020.102487
eISSN
2213-1582
Externe Identifier
  • PubMed Identifier: 33395978
  • PubMed Central ID: PMC7666350
Open access
true
ISSN
2213-1582
Zeitschrift
NeuroImage. Clinical
Schlüsselwörter
  • Humans
  • Magnetic Resonance Imaging
  • Brain Mapping
  • Social Behavior
  • Decision Making
  • Bipolar Disorder
  • Games, Experimental
Sprache
eng
Medium
Print-Electronic
Online publication date
2020
Open access status
Open Access
Paginierung
102487
Datum der Veröffentlichung
2020
Status
Published
Publisher licence
CC BY
Datum der Datenerfassung
2021
Titel
Altered neural responses to social fairness in bipolar disorder.
Sub types
  • Research Support, Non-U.S. Gov't
  • research-article
  • Journal Article
Ausgabe der Zeitschrift
28

Files

https://europepmc.org/articles/PMC7666350?pdf=render

Data source: Europe PubMed Central

Abstract
Bipolar Disorder (BD) has a debilitating impact on psychosocial functioning and social decision-making. Recent evidence using the Ultimatum Game (UG) has shown increased rejection of moderately unfair offers in BD, suggesting impaired processing of ambiguous social information related to fairness. The present study builds upon this finding to investigate the neural substrates of fairness processing in BD. During functional magnetic resonance imaging scanning, euthymic BD patients (n = 41) and matched healthy controls (HC; n = 41) accepted or rejected very unfair, moderately unfair, or fair offers in the UG. Acceptance rates of moderately unfair offers were significantly lower in BD patients. This aberrant behavior co-occurred with abnormal brain responses to moderately unfair offers. Compared to HC, BD patients exhibited hypoactivation of right anterior insula in response to moderately unfair offers suggesting impaired integration of affective and contextual information. BD patients also displayed stronger deactivation of posterior and middle insula in response to moderately unfair offers reflecting impaired processing of the contextual aspects of fairness. The level of impulsivity of BD patients positively correlated with the abnormal deactivation of posterior and middle insula. A separate analysis revealed increased activation of dorsal ACC and left ventrolateral PFC in response to rejected compared to accepted offers in BD patients. Taken together, our findings suggest impaired processing of ambiguous social information in euthymic BD patients which is associated with increased rejection of moderately unfair offers. This impairment may reflect a failure to integrate contextual information and may be related to increased trait impulsivity.
Date of acceptance
2020
Autoren
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/33395978
DOI
10.1016/j.nicl.2020.102487
eISSN
2213-1582
Externe Identifier
  • PubMed Central ID: PMC7666350
Zeitschrift
Neuroimage Clin
Schlüsselwörter
  • Ambiguity
  • Bipolar disorder
  • Fairness
  • Social decision-making
  • Ultimatum game
  • Bipolar Disorder
  • Brain Mapping
  • Decision Making
  • Games, Experimental
  • Humans
  • Magnetic Resonance Imaging
  • Social Behavior
Sprache
eng
Country
Netherlands
Paginierung
102487
PII
S2213-1582(20)30324-7
Datum der Veröffentlichung
2020
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2021
Titel
Altered neural responses to social fairness in bipolar disorder.
Sub types
  • Journal Article
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
28

Data source: PubMed

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