Impact of intraocular pressure fluctuations on progression of normal tension glaucoma
- Publication type:
- Journal article
- Metadata:
-
- Abstract
- <jats:p>AIM: To investigate short- and long-term intraocular pressure (IOP) fluctuations and further ocular and demographic parameters as predictors for normal tension glaucoma (NTG) progression. METHODS: This retrospective, longitudinal cohort study included 137 eyes of 75 patients with NTG, defined by glaucomatous optic disc or visual field defect with normal IOP (<21 mm Hg), independently from therapy regimen. IOP fluctuation, mean, and maximum were inspected with a mean follow-up of 38mo [standard deviation (SD) 18mo]. Inclusion criteria were the performance of minimum two 48-hour profiles including perimetry, Heidelberg retina tomograph (HRT) imaging, and optic disc photographs. The impact of IOP parameters, myopia, sex, cup-to-disc-ratio, and visual field results on progression of NTG were analyzed using Cox regression models. A sub-group analysis with results from optical coherence tomography (OCT) was performed. RESULTS: IOP fluctuations, average, and maximum were not risk factors for progression in NTG patients, although maximum IOP at the initial IOP profile was higher in eyes with progression than in eyes without progression (P=0.054). The 46/137 (33.5%) eyes progressed over the follow-up period. Overall progression (at least three progression confirmations) occurred in 28/137 eyes (20.4%). Most progressions were detected by perimetry (36/46). Long-term IOP mean over all pressure profiles was 12.8 mm Hg (SD 1.3 mm Hg); IOP fluctuation was 1.4 mm Hg (SD 0.8 mm Hg). The progression-free five-year rate was 58.2% (SD 6.5%). CONCLUSION: Short- and long-term IOP fluctuations do not result in progression of NTG. As functional changes are most likely to happen, NTG should be monitored with visual field testing more often than with other devices.</jats:p>
- Autoren
- Susanne Hopf
- Irene Schmidtmann
- Norbert Pfeiffer
- Esther Maria Hoffmann
- DOI
- 10.18240/ijo.2021.10.12
- eISSN
- 2227-4898
- ISSN
- 2222-3959
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- International Journal of Ophthalmology
- Paginierung
- 1553 - 1559
- Datum der Veröffentlichung
- 2021
- Status
- Published
- Herausgeber
- Press of International Journal of Ophthalmology (IJO Press)
- Herausgeber URL
- http://dx.doi.org/10.18240/ijo.2021.10.12
- Datum der Datenerfassung
- 2021
- Titel
- Impact of intraocular pressure fluctuations on progression of normal tension glaucoma
- Ausgabe der Zeitschrift
- 14
Data source: Crossref
- Other metadata sources:
-
- Author's licence
- CC-BY-NC-ND
- Autoren
- Susanne Hopf
- Doris Schwantuschke
- Irene Schmidtmann
- Norbert Pfeiffer
- Esther Maria Hoffmann
- Hosting institution
- Universitätsbibliothek Mainz
- Sammlungen
- JGU-Publikationen
- Resource version
- Published version
- DOI
- 10.18240/ijo.2021.10.12
- Funding acknowledgements
- Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz
- File(s) embargoed
- false
- Open access
- true
- ISSN
- 2227-4898
- Ausgabe der Veröffentlichung
- 10
- Zeitschrift
- International Journal of Ophthalmology
- Schlüsselwörter
- 610 Medizin
- 610 Medical sciences
- Sprache
- eng
- Open access status
- Open Access
- Paginierung
- 1553 - 1559
- Datum der Veröffentlichung
- 2021
- Public URL
- https://openscience.ub.uni-mainz.de/handle/20.500.12030/6720
- Herausgeber
- IJO Press
- Herausgeber URL
- https://doi.org/10.18240/ijo.2021.10.12
- Datum der Datenerfassung
- 2022
- Datum, an dem der Datensatz öffentlich gemacht wurde
- 2022
- Zugang
- Public
- Titel
- Impact of intraocular pressure fluctuations on progression of normal tension glaucoma
- Ausgabe der Zeitschrift
- 14
Files
impact_of_intraocular_pressur-20220118131343143.pdf
Data source: OPENSCIENCE.UB