Neuroimaging-based markers of bipolar disorder: Evidence from two meta-analyses

Publication type:
Journal article
Metadata:
Autoren
  • Josselin Houenou
  • Juliane Frommberger
  • Soufiane Carde
  • Manuela Glasbrenner
  • Carsten Diener
  • Marion Leboyer
  • Michele Wessa
Autoren-URL
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=fis-test-1&SrcAuth=WosAPI&KeyUT=WOS:000293721900006&DestLinkType=FullRecord&DestApp=WOS_CPL
DOI
10.1016/j.jad.2011.03.016
eISSN
1573-2517
Externe Identifier
  • Clarivate Analytics Document Solution ID: 805JE
  • PubMed Identifier: 21470688
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
JOURNAL OF AFFECTIVE DISORDERS
Schlüsselwörter
  • Bipolar disorder
  • Voxel-based morphometry
  • Functional magnetic resonance imaging
  • Emotion
  • Grey matter
Paginierung
344 - 355
Datum der Veröffentlichung
2011
Status
Published
Titel
Neuroimaging-based markers of bipolar disorder: Evidence from two meta-analyses
Sub types
  • Article
Ausgabe der Zeitschrift
132

Data source: Web of Science (Lite)

Other metadata sources:
Autoren
  • Josselin Houenou
  • Juliane Frommberger
  • Soufiane Carde
  • Manuela Glasbrenner
  • Carsten Diener
  • Marion Leboyer
  • Michèle Wessa
DOI
10.1016/j.jad.2011.03.016
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of Affective Disorders
Sprache
en
Paginierung
344 - 355
Datum der Veröffentlichung
2011
Status
Published
Herausgeber
Elsevier BV
Herausgeber URL
http://dx.doi.org/10.1016/j.jad.2011.03.016
Datum der Datenerfassung
2018
Titel
Neuroimaging-based markers of bipolar disorder: Evidence from two meta-analyses
Ausgabe der Zeitschrift
132

Data source: Crossref

Abstract
<h4>Background</h4>Bipolar disorder (BD) is often misdiagnosed or tardily detected, leading to inadequate treatment and devastating consequences. The identification of objective biomarkers, such as functional and structural brain abnormalities of BD might improve diagnosis and help elucidate its pathophysiology.<h4>Methods</h4>To identify neurobiological markers of BD, two meta-analyses, one of functional neuroimaging studies related to emotional processing and a second of structural whole-brain neuroimaging studies in BD were conducted in the present study. Conducting a literature search on studies published up to September 2009 we identified 28 studies that were eligible for the meta-analyses: 13 functional magnetic resonance imaging studies, related to emotional processing and 15 structural imaging studies using whole-brain voxel-based morphometry. Only studies comparing patients with bipolar disorder to healthy controls were considered. Data were extracted or converted to a single anatomical reference (Talairach space). The activation likelihood estimation technique was used to assess the voxel-wise correspondence of results between studies.<h4>Results</h4>In patients with BD, decreased activation and diminution of gray matter were identified in a cortical-cognitive brain network that has been associated with the regulation of emotions. By contrast, patients with BD exhibited increased activation in ventral limbic brain regions that mediate the experience of emotions and generation of emotional responses. The present study provides evidence for functional and anatomical alterations in BD in brain networks associated with the experience and regulation of emotions.<h4>Conclusions</h4>These alterations support previously proposed neurobiological models of BD and might represent valid neurobiological markers of the disorder. The specificity of these results to unipolar depression remains to be explored.
Addresses
  • INSERM, U 955, IMRB, Department of Medical Genomic, Psychiatry Genetic Team, University Paris Est-Créteil, Creteil, F-94000, France.
Autoren
  • Josselin Houenou
  • Juliane Frommberger
  • Soufiane Carde
  • Manuela Glasbrenner
  • Carsten Diener
  • Marion Leboyer
  • Michèle Wessa
DOI
10.1016/j.jad.2011.03.016
eISSN
1573-2517
Externe Identifier
  • PubMed Identifier: 21470688
Open access
false
ISSN
0165-0327
Ausgabe der Veröffentlichung
3
Zeitschrift
Journal of affective disorders
Schlüsselwörter
  • Brain
  • Prefrontal Cortex
  • Humans
  • Magnetic Resonance Imaging
  • Brain Mapping
  • Emotions
  • Bipolar Disorder
  • Biomarkers
Sprache
eng
Medium
Print-Electronic
Online publication date
2011
Paginierung
344 - 355
Datum der Veröffentlichung
2011
Status
Published
Datum der Datenerfassung
2011
Titel
Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses.
Sub types
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Journal Article
Ausgabe der Zeitschrift
132

Data source: Europe PubMed Central

Abstract
BACKGROUND: Bipolar disorder (BD) is often misdiagnosed or tardily detected, leading to inadequate treatment and devastating consequences. The identification of objective biomarkers, such as functional and structural brain abnormalities of BD might improve diagnosis and help elucidate its pathophysiology. METHODS: To identify neurobiological markers of BD, two meta-analyses, one of functional neuroimaging studies related to emotional processing and a second of structural whole-brain neuroimaging studies in BD were conducted in the present study. Conducting a literature search on studies published up to September 2009 we identified 28 studies that were eligible for the meta-analyses: 13 functional magnetic resonance imaging studies, related to emotional processing and 15 structural imaging studies using whole-brain voxel-based morphometry. Only studies comparing patients with bipolar disorder to healthy controls were considered. Data were extracted or converted to a single anatomical reference (Talairach space). The activation likelihood estimation technique was used to assess the voxel-wise correspondence of results between studies. RESULTS: In patients with BD, decreased activation and diminution of gray matter were identified in a cortical-cognitive brain network that has been associated with the regulation of emotions. By contrast, patients with BD exhibited increased activation in ventral limbic brain regions that mediate the experience of emotions and generation of emotional responses. The present study provides evidence for functional and anatomical alterations in BD in brain networks associated with the experience and regulation of emotions. CONCLUSIONS: These alterations support previously proposed neurobiological models of BD and might represent valid neurobiological markers of the disorder. The specificity of these results to unipolar depression remains to be explored.
Date of acceptance
2011
Autoren
  • Josselin Houenou
  • Juliane Frommberger
  • Soufiane Carde
  • Manuela Glasbrenner
  • Carsten Diener
  • Marion Leboyer
  • Michèle Wessa
Autoren-URL
https://www.ncbi.nlm.nih.gov/pubmed/21470688
DOI
10.1016/j.jad.2011.03.016
eISSN
1573-2517
Ausgabe der Veröffentlichung
3
Zeitschrift
J Affect Disord
Schlüsselwörter
  • Biomarkers
  • Bipolar Disorder
  • Brain
  • Brain Mapping
  • Emotions
  • Humans
  • Magnetic Resonance Imaging
  • Prefrontal Cortex
Sprache
eng
Country
Netherlands
Paginierung
344 - 355
PII
S0165-0327(11)00099-1
Datum der Veröffentlichung
2011
Status
Published
Datum, an dem der Datensatz öffentlich gemacht wurde
2011
Titel
Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses.
Sub types
  • Journal Article
  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
Ausgabe der Zeitschrift
132

Data source: PubMed

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